Proteolysis of Insulin-Like Growth Factors (IGF) and IGF Binding Proteins by Cathepsin D

Abstract Various proteinases have been postulated to function in limited proteolysis of insulin-like growth factor binding proteins (IGFBPs) contributing to the regulation of IGF bioavailability. In this study, we report on the in vitro degradation of IGFs and IGFBPs by the purified acidic aspartylp...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-09, Vol.138 (9), p.3797-3803
Hauptverfasser:	Claussen, Max, Kübler, Bernd, Wendland, Martin, Neifer, Klaus, Schmidt, Bernhard, Zapf, Jürgen, Braulke, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Binding Bioavailability Cathepsin D Cleavage Fragments Growth factors Inactivation Insulin Insulin-like growth factor I Insulin-like growth factor-binding protein 1 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 6 Insulin-like growth factors Platelet-derived growth factor Platelet-derived growth factor BB Proteins Proteolysis Sequence analysis
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