The Fas System, a Regulator of Testicular Germ Cell Apoptosis, Is Differentially Up-Regulated in Sertoli Cell Versus Germ Cell Injury of the Testis

Abstract Sertoli cells, the supportive cells in the seminiferous epithelium, orchestrate spermatogenesis by providing structural and nutritional support to germ cells. In the rat, physiological apoptosis occurs continuously to limit the size of the germ cell population to numbers that can be adequat...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-02, Vol.140 (2), p.852-858
Hauptverfasser:	Lee, Jeongwu, Richburg, John H., Shipp, Elizabeth B., Meistrich, Marvin L., Boekelheide, Kim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Cell activation Cell culture Cell death Cell injury Cell size Contaminants Diethylhexyl Phthalate - analogs & derivatives Diethylhexyl Phthalate - poisoning Environmental conditions Epithelium Fas antigen Fas Ligand Protein fas Receptor FasL protein Gene expression Germ cells Hexanones - poisoning Injury prevention Kinetics Male Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mortality Neuropeptides - metabolism Neuropeptides - physiology Radiation Radiation effects Rats Rats, Inbred Strains Receptors, Tumor Necrosis Factor Sertoli cells Sertoli Cells - drug effects Sertoli Cells - physiology Sertoli Cells - radiation effects Spermatogenesis Spermatozoa - drug effects Spermatozoa - physiology Spermatozoa - radiation effects Testes Toxicants Up-regulation
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