Expression of the Interleukin-6 Gene Is Constitutive and Not Regulated by Estrogen in Rat Vascular Smooth Muscle Cells in Culture

Abstract Vascular smooth muscle cells (SMC) are major constituents of the medial layer of blood vessels and are involved in the development of atherosclerotic plaque. SMC secrete copious IL-6 under basal conditions that can be increased by cytokines such as tumor necrosis factor-α and interleukin-1β...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-06, Vol.140 (6), p.2876-2882
Hauptverfasser:	Maret, Arlette, Clamens, Simone, Delrieu, Isabelle, Elhage, Rima, Arnal, Jean-François, Bayard, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Acetyltransferase Activator protein 1 Animals Arteriosclerosis Atherosclerosis Biological activity Blood vessels CCAAT/enhancer-binding protein Cell culture Cells, Cultured Chloramphenicol Chloramphenicol O-acetyltransferase Chloromycetin Culture Cytokines Down-regulation Estrogen receptors Estrogens Estrogens - pharmacology Ethinylestradiol Female Gene deletion Gene Expression Regulation - drug effects IL-1β Interleukin 1 Interleukin 6 Interleukin-1 - pharmacology Interleukin-6 - biosynthesis Interleukin-6 - genetics Interleukins Muscle, Smooth, Vascular - metabolism NF-κB protein Nucleotide sequence Nucleotides Promoter Regions, Genetic Protein folding Rats Rats, Wistar Reporter gene Sex hormones Site-directed mutagenesis Smooth muscle Stimulation
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