Glucagon-Like Peptide-1 Regulates the Beta Cell Transcription Factor, PDX-1, in Insulinoma Cells

Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects throug...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-10, Vol.140 (10), p.4904-4907
Hauptverfasser:	Wang, Xiaolin, Cahill, Catherine M, Piñeyro, Marco A, Zhou, Jie, Doyle, Máire E, Egan, Josephine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta cells Biosynthesis Diabetes mellitus Diabetes mellitus (non-insulin dependent) Electrophoretic mobility Glucagon Glucagon-like peptide 1 Glucokinase Glucose transporter Insulin Insulinoma Pdx-1 protein Peptides Protein folding Proteins
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