3′,5′-Cyclic Adenosine Monophosphate Activation in Osteoblastic Cells: Effects on Parathyroid Hormone-1 Receptors and Osteoblastic Differentiation in Vitro

Abstract PTH has anabolic and catabolic effects in bone through activation of the PTH-1 (PTH/PTHrP) receptor and the cAMP/protein kinase A pathway. The effects of agents that regulate cAMP in nontransformed osteoblasts in relation to cell differentiation have not been described. The purpose of this...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-07, Vol.140 (7), p.3154-3162
Hauptverfasser:	Koh, Amy J., Beecher, Christopher A., Rosol, Thomas J., McCauley, Laurie K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenine Adenosine monophosphate Adenosine receptors Adenylate cyclase Analogs Binding sites Cell activation Cell differentiation Cell surface Cell surface receptors Cyclic AMP Differentiation (biology) Down-regulation Forskolin Gene expression Kinases Nodules Osteoblastogenesis Osteoblasts Osteocalcin Parathyroid hormone Parathyroid hormone-related protein Protein kinase A Receptors Stimulators
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