Glucose-Dependent Insulinotropic Polypeptide Confers Early Phase Insulin Release to Oral Glucose in Rats: Demonstration by a Receptor Antagonist

Abstract A novel GIP receptor antagonist was developed to evaluate the acute role of glucose-dependent insulinotropic polypeptide (GIP) in the insulin response to oral glucose in rats. Antisera to an extracellular epitope of the GIP receptor (GIPR) detected immunoreactive GIPR on rat pancreatic β-ce...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2000-10, Vol.141 (10), p.3710-3716
Hauptverfasser:	Lewis, Jamie T., Dayanandan, Bama, Habener, Joel F., Kieffer, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisera Beta cells Epitopes GIP protein Glucagon Glucagon-like peptide 1 Glucose Insulin Insulin secretion Pancreas Polypeptides Receptors
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