Immunodetection of 11β-Hydroxysteroid Dehydrogenase Type 2 in Human Mineralocorticoid Target Tissues: Evidence for Nuclear Localization

Abstract 11β-Hydroxysteroid dehydrogenase (11βHSD) is an enzyme complex responsible for the conversion of hormonally active cortisol to inactive cortisone; two isoforms of the enzyme have been cloned and characterized. Clinical observations from patients with the hypertensive syndrome apparent miner...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-03, Vol.138 (3), p.1305-1311
Hauptverfasser:	Shimojo, Masako, Ricketts, Marie L., Petrelli, Massimiliano D., Moradi, Phillip, Johnson, Gerald D., Bradwell, A. R., Hewison, Martin, Howie, Alexander J., Stewart, Paul M.
Format:	Artikel
Sprache:	eng
Schlagworte:	11β-Hydroxysteroid dehydrogenase Aldosterone Antibodies Autocrine signalling Colon Cortisol Cortisone Decidua Dehydrogenase Dehydrogenases Enzymes Epithelial cells Epithelium Glucocorticoids Hormones Hydroxysteroids Immunofluorescence Iodides Isoforms Kidneys Laser microscopy Localization Mineralocorticoid receptors Nuclei (cytology) Parotid gland Peptides Propidium iodide Salivary gland Salivary glands Staining Tissues
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