Ca2+-Regulated Expression of Aldosterone Synthase Is Mediated By Calmodulin and Calmodulin-Dependent Protein Kinases

The chronic maintenance of aldosterone production in the adrenal zona glomerulosa is associated with increased expression of aldosterone synthase (P450aldo), the enzyme responsible for the conversion of 11-deoxycorticosterone to aldosterone. The major physiologic regulators of aldosterone production...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-02, Vol.138 (2), p.835-838
Hauptverfasser:	Pezzi, Vincenzo, Clyne, Colin D, Ando, Sebastiano, Mathis, J. Michael, Rainey, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenals. Interrenals Adrenomedullary hormones. Regulation Aldosterone Aldosterone synthase Angiotensin Angiotensin II Biological and medical sciences Ca2+/calmodulin-dependent protein kinase Calcium (intracellular) Calcium channels Calcium compounds Calcium ionophores Calcium ions Calmodulin Cyclic AMP Fundamental and applied biological sciences. Psychology Gene expression Ionomycin Kinases Vertebrates: endocrinology
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