Androgen Receptor Up-Regulates Insulin-Like Growth Factor Binding Protein-5 (IGFBP-5) Expression in a Human Prostate Cancer Xenograft

Abstract The insulin-like growth factor (IGF) binding proteins (IGFBPs) are important modulators of IGF action in many tissues including human prostate. IGFBPs and the androgen receptor (AR) are expressed in CWR22, an androgen-dependent epithelial cell human CaP xenograft that retains biological cha...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-05, Vol.140 (5), p.2372-2381
Hauptverfasser:	Gregory, Christopher W., Kim, Desok, Ye, Ping, D’Ercole, A. Joseph, Pretlow, Thomas G., Mohler, James L., French, Frank S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Androgens Castration Cell membranes Cell proliferation Epithelial cells Epithelium Gene expression Growth factors Hybridization Hyperplasia Immunoblotting Immunomodulation Insulin Insulin-like growth factor I Insulin-like growth factor-binding protein 5 Insulin-like growth factors mRNA Prostate Prostate cancer Protein folding Proteins Receptors Stromal cells Testosterone Tumors Xenografts Xenotransplantation
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