Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling

Abstract Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-05, Vol.140 (5), p.2387-2397
Hauptverfasser:	Wilson, Brent D., Bagnol, Didier, Kaelin, Christopher B., Ollmann, Michael M., Gantz, Ira, Watson, Stanley J., Barsh, Gregory S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti-related protein Arcuate nucleus Circuits Fasting Hybridization Hypothalamus Hypothalamus (dorsomedial) Immunocytochemistry Melanocortin receptors mRNA Mutation Neurons Nuclei (cytology) Physiological effects Proopiomelanocortin Protein folding Proteins Receptors Weight loss
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