Regulation by Thyroid-Stimulating Hormone of Sodium/Iodide Symporter Gene Expression and Protein Levels in FRTL-5 Cells

To investigate the mechanism of I− transport stimulation by TSH, we studied the effects of TSH on Na+/I− symporter (NIS) messenger RNA (mRNA) and protein levels in FRTL-5 cells and correlated these with I− transport activity. When 1 mU/ml TSH was added to quiescent FRTL-5 cells, a 12-h latency was o...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-06, Vol.138 (6), p.2227-2232
Hauptverfasser:	Kogai, Takahiko, Endo, Toyoshi, Saito, Tsukasa, Miyazaki, Asako, Kawaguchi, Akio, Onaya, Toshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell membranes Forskolin Gene expression Iodides Latency NIS gene NIS protein Protein biosynthesis Protein synthesis Protein transport Proteins RNA transport Sodium Sodium iodide symporter Stimulation Thyrocytes Thyroid Thyroid-stimulating hormone
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