Morphological Changes Induced by 6-Month Treatment of Intact and Ovariectomized Mice with Tamoxifen and the Pure Antiestrogen EM-800

The present study compares the effects of tamoxifen and EM-800, both administered at the oral daily dose of 100 μg for 6 months, on the uterus, vagina, and mammary gland in the mouse at histopathological examination. Treatment of intact animals with EM-800 resulted in uterine and vaginal atrophy eve...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1997-12, Vol.138 (12), p.5605-5617
Hauptverfasser:	Sourla, Antigone, Luo, Shouqi, Labrie, Claude, Bélanger, Alain, Labrie, Fernand
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - metabolism Animals Antiestrogens Atrophy Benzopyrans - pharmacology Endometrial Hyperplasia - chemically induced Endometrial Hyperplasia - pathology Endometrium Estrogen Antagonists - pharmacology Estrogenic activity Estrogens Female Hydroxysteroids Hyperplasia Luteinizing Hormone - blood Mammary gland Mammary glands Mammary Glands, Animal - drug effects Mammary Glands, Animal - enzymology Mammary Glands, Animal - pathology Mice Mice, Inbred BALB C Morphology Organ Size - drug effects Ovariectomy Ovaries Ovary - drug effects Ovary - pathology Propionates - pharmacology Reductases Steroid 5α-reductase Stimulation Stroma Tamoxifen Tamoxifen - pharmacology Uterus Uterus - drug effects Uterus - pathology Vagina Vagina - drug effects Vagina - pathology Xenoestrogens
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