The role of the asparagine-linked oligosaccharides of the alpha-subunit in human thyrotropin bioactivity

TSH and the gonadotropins (FSH, LH, and hCG) are a family of heterodimeric proteins that share a common alpha-subunit and differ in their hormone-specific beta-subunit. The asparagine-linked (N-linked) oligosaccharides on these hormones are important in signal transduction. The N-linked oligosacchar...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1996-02, Vol.137 (2), p.555-560
Hauptverfasser:	Fares, F A, Gruener, N, Kraiem, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Asparagine Aspartic acid Biological activity Biological effects Carbohydrates Cell culture Conserved sequence Cyclic AMP Deletion Dimers Follicle-stimulating hormone Follicles Gene transfer Glycosylation Gonadotropins Hormones Luteinizing hormone Oligosaccharides Pituitary (anterior) Secretion Signal transduction Site-directed mutagenesis Thyroid Thyroid gland Thyroid-stimulating hormone Triiodothyronine
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