A study on brain asymmetry in temporal lobe epilepsy
Objective: Temporal lobe epilepsy (TLE) accompanied by hippocampal sclerosis (HS) is the most common type of focal epilepsies. Hemispheric asymmetry is a feature of brain organization in both invertebrates and vertebrates and may be the key to some neurodegenerative diseases. In this context, we aim...
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| Veröffentlicht in: | Marmara Medical Journal 2024-01, Vol.37 (2), p.144-151 |
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| creator | Bilişli Kara, Edibe Fırat, Zeynep Uluğ, Aziz M. Ekinci, Gazanfer Şehirli, Ümit |
| description | Objective: Temporal lobe epilepsy (TLE) accompanied by hippocampal sclerosis (HS) is the most common type of focal epilepsies.
Hemispheric asymmetry is a feature of brain organization in both invertebrates and vertebrates and may be the key to some
neurodegenerative diseases. In this context, we aimed to investigate the volumetric asymmetry difference in cerebral structures
between TLE patients and the healthy control group, based on magnetic resonance imaging (MRI) data that may be used as a new
neuroimaging marker for TLE cases.
Patients and Methods: In this retrospective study the cranial MRIs of fourteen clinically manifesting, radiologically HS-identified,
and diagnosed TLE patients and fourteen healthy individuals from the Radiology Department of Yeditepe University Hospital were
evaluated. Volume measurements and asymmetry index (AI) calculations in the total brain, hippocampus, temporal lobe, amygdala,
thalamus, nucleus accumbens (NAc), premotor cortex, primary and somatosensory cortices were performed using the medical
NeuroQuant® software. A negative AI value represented asymmetry towards the right due to reduced left hemispheric volume; a
positive AI value represented asymmetry towards the left due to reduced right hemispheric volume. Subsequently, differences in
volume and asymmetric patterns were investigated among TLE subgroups (right and left-sided TLE) and controls.
Results: The left-sided TLE patients showed significant bilateral total brain volume reduction compared to the control group. Significant
ipsilateral volumetric declines were also detected in the premotor cortex, the temporal lobe, and NAc with remarkable asymmetry to
the right side. No significant changes were detected in right-sided TLE patients compared to the other groups.
Conclusion: Overall, findings suggest that TLE patients had volumetric alterations with symmetry changes beyond the mesial temporal
structures. With further investigations, the asymmetry measures can provide additional knowledge for TLE diagnosis. |
| doi_str_mv | 10.5472/marumj.1487475 |
| format | Article |
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Hemispheric asymmetry is a feature of brain organization in both invertebrates and vertebrates and may be the key to some
neurodegenerative diseases. In this context, we aimed to investigate the volumetric asymmetry difference in cerebral structures
between TLE patients and the healthy control group, based on magnetic resonance imaging (MRI) data that may be used as a new
neuroimaging marker for TLE cases.
Patients and Methods: In this retrospective study the cranial MRIs of fourteen clinically manifesting, radiologically HS-identified,
and diagnosed TLE patients and fourteen healthy individuals from the Radiology Department of Yeditepe University Hospital were
evaluated. Volume measurements and asymmetry index (AI) calculations in the total brain, hippocampus, temporal lobe, amygdala,
thalamus, nucleus accumbens (NAc), premotor cortex, primary and somatosensory cortices were performed using the medical
NeuroQuant® software. A negative AI value represented asymmetry towards the right due to reduced left hemispheric volume; a
positive AI value represented asymmetry towards the left due to reduced right hemispheric volume. Subsequently, differences in
volume and asymmetric patterns were investigated among TLE subgroups (right and left-sided TLE) and controls.
Results: The left-sided TLE patients showed significant bilateral total brain volume reduction compared to the control group. Significant
ipsilateral volumetric declines were also detected in the premotor cortex, the temporal lobe, and NAc with remarkable asymmetry to
the right side. No significant changes were detected in right-sided TLE patients compared to the other groups.
Conclusion: Overall, findings suggest that TLE patients had volumetric alterations with symmetry changes beyond the mesial temporal
structures. With further investigations, the asymmetry measures can provide additional knowledge for TLE diagnosis.</description><identifier>ISSN: 1019-1941</identifier><identifier>EISSN: 1309-9469</identifier><identifier>DOI: 10.5472/marumj.1487475</identifier><language>eng</language><publisher>Istanbul: Marmara University</publisher><subject>Asymmetry ; Epilepsy</subject><ispartof>Marmara Medical Journal, 2024-01, Vol.37 (2), p.144-151</ispartof><rights>2024. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://dergipark.org.tr/en/pub/marumj/about-journal</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c192t-5ae19ea22da443c03959d50c5c4c608c16612707818b21a6b10d73a8166071593</cites><orcidid>0000-0001-6261-4567 ; 0000-0002-1589-1833 ; 0000-0002-1610-8628 ; 0000-0002-2315-0322 ; 0000-0001-6810-6360</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Bilişli Kara, Edibe</creatorcontrib><creatorcontrib>Fırat, Zeynep</creatorcontrib><creatorcontrib>Uluğ, Aziz M.</creatorcontrib><creatorcontrib>Ekinci, Gazanfer</creatorcontrib><creatorcontrib>Şehirli, Ümit</creatorcontrib><title>A study on brain asymmetry in temporal lobe epilepsy</title><title>Marmara Medical Journal</title><description>Objective: Temporal lobe epilepsy (TLE) accompanied by hippocampal sclerosis (HS) is the most common type of focal epilepsies.
Hemispheric asymmetry is a feature of brain organization in both invertebrates and vertebrates and may be the key to some
neurodegenerative diseases. In this context, we aimed to investigate the volumetric asymmetry difference in cerebral structures
between TLE patients and the healthy control group, based on magnetic resonance imaging (MRI) data that may be used as a new
neuroimaging marker for TLE cases.
Patients and Methods: In this retrospective study the cranial MRIs of fourteen clinically manifesting, radiologically HS-identified,
and diagnosed TLE patients and fourteen healthy individuals from the Radiology Department of Yeditepe University Hospital were
evaluated. Volume measurements and asymmetry index (AI) calculations in the total brain, hippocampus, temporal lobe, amygdala,
thalamus, nucleus accumbens (NAc), premotor cortex, primary and somatosensory cortices were performed using the medical
NeuroQuant® software. A negative AI value represented asymmetry towards the right due to reduced left hemispheric volume; a
positive AI value represented asymmetry towards the left due to reduced right hemispheric volume. Subsequently, differences in
volume and asymmetric patterns were investigated among TLE subgroups (right and left-sided TLE) and controls.
Results: The left-sided TLE patients showed significant bilateral total brain volume reduction compared to the control group. Significant
ipsilateral volumetric declines were also detected in the premotor cortex, the temporal lobe, and NAc with remarkable asymmetry to
the right side. No significant changes were detected in right-sided TLE patients compared to the other groups.
Conclusion: Overall, findings suggest that TLE patients had volumetric alterations with symmetry changes beyond the mesial temporal
structures. With further investigations, the asymmetry measures can provide additional knowledge for TLE diagnosis.</description><subject>Asymmetry</subject><subject>Epilepsy</subject><issn>1019-1941</issn><issn>1309-9469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNotkLtqxDAQRUVIIJtN2tSC1HZm9LCkclnygoU0SS1kWQs2fkWyC_99vHirO3c4zMAh5Bkhl0Kx187FuWtyFFoJJW_IDjmYzIjC3K4zoMnQCLwnDyk1AFKDKXZEHGia5mqhQ0_L6OqeurR0XZjiQtcyhW4comtpO5SBhrFuw5iWR3J3dm0KT9fck9_3t5_jZ3b6_vg6Hk6ZR8OmTLqAJjjGKicE98CNNJUEL73wBWiPRYFMgdKoS4auKBEqxZ1e96BQGr4nL9vdMQ5_c0iTbYY59utLy5Fpxjjihco3yschpRjOdoz1KmOxCPZixm5m7NUM_wdIR1WZ</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Bilişli Kara, Edibe</creator><creator>Fırat, Zeynep</creator><creator>Uluğ, Aziz M.</creator><creator>Ekinci, Gazanfer</creator><creator>Şehirli, Ümit</creator><general>Marmara University</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-6261-4567</orcidid><orcidid>https://orcid.org/0000-0002-1589-1833</orcidid><orcidid>https://orcid.org/0000-0002-1610-8628</orcidid><orcidid>https://orcid.org/0000-0002-2315-0322</orcidid><orcidid>https://orcid.org/0000-0001-6810-6360</orcidid></search><sort><creationdate>20240101</creationdate><title>A study on brain asymmetry in temporal lobe epilepsy</title><author>Bilişli Kara, Edibe ; Fırat, Zeynep ; Uluğ, Aziz M. ; Ekinci, Gazanfer ; Şehirli, Ümit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c192t-5ae19ea22da443c03959d50c5c4c608c16612707818b21a6b10d73a8166071593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Asymmetry</topic><topic>Epilepsy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bilişli Kara, Edibe</creatorcontrib><creatorcontrib>Fırat, Zeynep</creatorcontrib><creatorcontrib>Uluğ, Aziz M.</creatorcontrib><creatorcontrib>Ekinci, Gazanfer</creatorcontrib><creatorcontrib>Şehirli, Ümit</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Marmara Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bilişli Kara, Edibe</au><au>Fırat, Zeynep</au><au>Uluğ, Aziz M.</au><au>Ekinci, Gazanfer</au><au>Şehirli, Ümit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study on brain asymmetry in temporal lobe epilepsy</atitle><jtitle>Marmara Medical Journal</jtitle><date>2024-01-01</date><risdate>2024</risdate><volume>37</volume><issue>2</issue><spage>144</spage><epage>151</epage><pages>144-151</pages><issn>1019-1941</issn><eissn>1309-9469</eissn><abstract>Objective: Temporal lobe epilepsy (TLE) accompanied by hippocampal sclerosis (HS) is the most common type of focal epilepsies.
Hemispheric asymmetry is a feature of brain organization in both invertebrates and vertebrates and may be the key to some
neurodegenerative diseases. In this context, we aimed to investigate the volumetric asymmetry difference in cerebral structures
between TLE patients and the healthy control group, based on magnetic resonance imaging (MRI) data that may be used as a new
neuroimaging marker for TLE cases.
Patients and Methods: In this retrospective study the cranial MRIs of fourteen clinically manifesting, radiologically HS-identified,
and diagnosed TLE patients and fourteen healthy individuals from the Radiology Department of Yeditepe University Hospital were
evaluated. Volume measurements and asymmetry index (AI) calculations in the total brain, hippocampus, temporal lobe, amygdala,
thalamus, nucleus accumbens (NAc), premotor cortex, primary and somatosensory cortices were performed using the medical
NeuroQuant® software. A negative AI value represented asymmetry towards the right due to reduced left hemispheric volume; a
positive AI value represented asymmetry towards the left due to reduced right hemispheric volume. Subsequently, differences in
volume and asymmetric patterns were investigated among TLE subgroups (right and left-sided TLE) and controls.
Results: The left-sided TLE patients showed significant bilateral total brain volume reduction compared to the control group. Significant
ipsilateral volumetric declines were also detected in the premotor cortex, the temporal lobe, and NAc with remarkable asymmetry to
the right side. No significant changes were detected in right-sided TLE patients compared to the other groups.
Conclusion: Overall, findings suggest that TLE patients had volumetric alterations with symmetry changes beyond the mesial temporal
structures. With further investigations, the asymmetry measures can provide additional knowledge for TLE diagnosis.</abstract><cop>Istanbul</cop><pub>Marmara University</pub><doi>10.5472/marumj.1487475</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6261-4567</orcidid><orcidid>https://orcid.org/0000-0002-1589-1833</orcidid><orcidid>https://orcid.org/0000-0002-1610-8628</orcidid><orcidid>https://orcid.org/0000-0002-2315-0322</orcidid><orcidid>https://orcid.org/0000-0001-6810-6360</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1019-1941 1309-9469 |
| language | eng |
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| subjects | Asymmetry Epilepsy |
| title | A study on brain asymmetry in temporal lobe epilepsy |
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