Thyroid dose from common head and neck CT examinations in children: is there an excess risk for thyroid cancer induction?
This study was conducted to estimate thyroid dose and the associated risk for thyroid cancer induction from common head and neck computed tomography (CT) examinations during childhood. The Monte Carlo N-particle transport code was employed to simulate the routine CT scanning of the brain, paranasal...
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| Veröffentlicht in: | European radiology 2007-05, Vol.17 (5), p.1352-1357 |
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| description | This study was conducted to estimate thyroid dose and the associated risk for thyroid cancer induction from common head and neck computed tomography (CT) examinations during childhood. The Monte Carlo N-particle transport code was employed to simulate the routine CT scanning of the brain, paranasal sinuses, inner ear and neck performed on sequential and/or spiral modes. The mean thyroid dose was calculated using mathematical phantoms representing a newborn infant and children of 1year, 5 years, 10 years and 15 years old. To verify Monte Carlo results, dose measurements were carried out on physical anthropomorphic phantoms using thermoluminescent dosemeters (TLDs). The scattered dose to thyroid from head CT examinations varied from 0.6 mGy to 8.7 mGy depending upon the scanned region, the pediatric patient's age and the acquisition mode used. Primary irradiation of the thyroid gland during CT of the neck resulted in an absorbed dose range of 15.2-52.0 mGy. The mean difference between Monte Carlo calculations and TLD measurements was 11.8%. Thyroid exposure to scattered radiation from head CT scanning is associated with a low but not negligible risk of cancer induction of 4-65 per million patients. Neck CT can result in an increased risk for development of thyroid malignancies up to 390 per million patients. |
| doi_str_mv | 10.1007/s00330-006-0417-9 |
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The Monte Carlo N-particle transport code was employed to simulate the routine CT scanning of the brain, paranasal sinuses, inner ear and neck performed on sequential and/or spiral modes. The mean thyroid dose was calculated using mathematical phantoms representing a newborn infant and children of 1year, 5 years, 10 years and 15 years old. To verify Monte Carlo results, dose measurements were carried out on physical anthropomorphic phantoms using thermoluminescent dosemeters (TLDs). The scattered dose to thyroid from head CT examinations varied from 0.6 mGy to 8.7 mGy depending upon the scanned region, the pediatric patient's age and the acquisition mode used. Primary irradiation of the thyroid gland during CT of the neck resulted in an absorbed dose range of 15.2-52.0 mGy. The mean difference between Monte Carlo calculations and TLD measurements was 11.8%. Thyroid exposure to scattered radiation from head CT scanning is associated with a low but not negligible risk of cancer induction of 4-65 per million patients. Neck CT can result in an increased risk for development of thyroid malignancies up to 390 per million patients.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-006-0417-9</identifier><identifier>PMID: 17021703</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adolescent ; Cancer ; Child ; Child, Preschool ; Children ; Computed tomography ; Head ; Head & neck cancer ; Head - diagnostic imaging ; Head and neck ; Health risks ; Humans ; Infant ; Infant, Newborn ; Inner ear ; Irradiation ; Malignancy ; Medical imaging ; Monte Carlo Method ; Monte Carlo simulation ; Neck ; Neck - diagnostic imaging ; Neoplasms, Radiation-Induced - etiology ; Paranasal sinus ; Paranasal sinuses ; Pediatrics ; Phantoms, Imaging ; Radiation Dosage ; Radiation measurement ; Radiometry - methods ; Risk ; Risk Assessment ; Scanning ; Scattering, Radiation ; Sinuses ; Thermoluminescent Dosimetry ; Thyroid ; Thyroid cancer ; Thyroid gland ; Thyroid Gland - radiation effects ; Thyroid Neoplasms - etiology ; Tomography, X-Ray Computed</subject><ispartof>European radiology, 2007-05, Vol.17 (5), p.1352-1357</ispartof><rights>Springer-Verlag 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-c7919a3ee2ab062cd31cff7bf225a0462eb02e92e30745ddb2647f08f087b2993</citedby><cites>FETCH-LOGICAL-c327t-c7919a3ee2ab062cd31cff7bf225a0462eb02e92e30745ddb2647f08f087b2993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17021703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mazonakis, Michalis</creatorcontrib><creatorcontrib>Tzedakis, Antonis</creatorcontrib><creatorcontrib>Damilakis, John</creatorcontrib><creatorcontrib>Gourtsoyiannis, Nicholas</creatorcontrib><title>Thyroid dose from common head and neck CT examinations in children: is there an excess risk for thyroid cancer induction?</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>This study was conducted to estimate thyroid dose and the associated risk for thyroid cancer induction from common head and neck computed tomography (CT) examinations during childhood. The Monte Carlo N-particle transport code was employed to simulate the routine CT scanning of the brain, paranasal sinuses, inner ear and neck performed on sequential and/or spiral modes. The mean thyroid dose was calculated using mathematical phantoms representing a newborn infant and children of 1year, 5 years, 10 years and 15 years old. To verify Monte Carlo results, dose measurements were carried out on physical anthropomorphic phantoms using thermoluminescent dosemeters (TLDs). The scattered dose to thyroid from head CT examinations varied from 0.6 mGy to 8.7 mGy depending upon the scanned region, the pediatric patient's age and the acquisition mode used. Primary irradiation of the thyroid gland during CT of the neck resulted in an absorbed dose range of 15.2-52.0 mGy. The mean difference between Monte Carlo calculations and TLD measurements was 11.8%. Thyroid exposure to scattered radiation from head CT scanning is associated with a low but not negligible risk of cancer induction of 4-65 per million patients. Neck CT can result in an increased risk for development of thyroid malignancies up to 390 per million patients.</description><subject>Adolescent</subject><subject>Cancer</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Computed tomography</subject><subject>Head</subject><subject>Head & neck cancer</subject><subject>Head - diagnostic imaging</subject><subject>Head and neck</subject><subject>Health risks</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inner ear</subject><subject>Irradiation</subject><subject>Malignancy</subject><subject>Medical imaging</subject><subject>Monte Carlo Method</subject><subject>Monte Carlo simulation</subject><subject>Neck</subject><subject>Neck - diagnostic imaging</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Paranasal sinus</subject><subject>Paranasal sinuses</subject><subject>Pediatrics</subject><subject>Phantoms, Imaging</subject><subject>Radiation Dosage</subject><subject>Radiation measurement</subject><subject>Radiometry - methods</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Scanning</subject><subject>Scattering, Radiation</subject><subject>Sinuses</subject><subject>Thermoluminescent Dosimetry</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - radiation effects</subject><subject>Thyroid Neoplasms - etiology</subject><subject>Tomography, X-Ray Computed</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkE1LAzEQhoMotlZ_gBcJeF6dfHTTeBEpfkHBSz2HbDJLt-0mNWnB_ntTWhBmmMO88ww8hNwyeGAA6jEDCAEVQF2BZKrSZ2TIpOAVg4k8J0PQYlIpreWAXOW8BADNpLokA6aAlxZDsp8v9il2nvqYkbYp9tTFvo-BLtB6aoOnAd2KTucUf23fBbvtYsi0C9QturVPGJ5ol-l2gQlLvKQc5kxTl1e0jaksjnxng8NU7vzOHRDP1-SiteuMN6c5It9vr_PpRzX7ev-cvswqJ7jaVk5ppq1A5LaBmjsvmGtb1bScjy3ImmMDHDVHAUqOvW94LVULk1Kq4VqLEbk_cjcp_uwwb80y7lIoL41gXEkGopYlxY4pl2LOCVuzSV1v094wMAfZ5ijbFNnmINscyHcn8q7p0f9fnOyKP7KHeno</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Mazonakis, Michalis</creator><creator>Tzedakis, Antonis</creator><creator>Damilakis, John</creator><creator>Gourtsoyiannis, Nicholas</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20070501</creationdate><title>Thyroid dose from common head and neck CT examinations in children: is there an excess risk for thyroid cancer induction?</title><author>Mazonakis, Michalis ; Tzedakis, Antonis ; Damilakis, John ; Gourtsoyiannis, Nicholas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-c7919a3ee2ab062cd31cff7bf225a0462eb02e92e30745ddb2647f08f087b2993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Cancer</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Computed tomography</topic><topic>Head</topic><topic>Head & neck cancer</topic><topic>Head - diagnostic imaging</topic><topic>Head and neck</topic><topic>Health risks</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Inner ear</topic><topic>Irradiation</topic><topic>Malignancy</topic><topic>Medical imaging</topic><topic>Monte Carlo Method</topic><topic>Monte Carlo simulation</topic><topic>Neck</topic><topic>Neck - diagnostic imaging</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Paranasal sinus</topic><topic>Paranasal sinuses</topic><topic>Pediatrics</topic><topic>Phantoms, Imaging</topic><topic>Radiation Dosage</topic><topic>Radiation measurement</topic><topic>Radiometry - methods</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Scanning</topic><topic>Scattering, Radiation</topic><topic>Sinuses</topic><topic>Thermoluminescent Dosimetry</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - radiation effects</topic><topic>Thyroid Neoplasms - etiology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazonakis, Michalis</creatorcontrib><creatorcontrib>Tzedakis, Antonis</creatorcontrib><creatorcontrib>Damilakis, John</creatorcontrib><creatorcontrib>Gourtsoyiannis, Nicholas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazonakis, Michalis</au><au>Tzedakis, Antonis</au><au>Damilakis, John</au><au>Gourtsoyiannis, Nicholas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid dose from common head and neck CT examinations in children: is there an excess risk for thyroid cancer induction?</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>17</volume><issue>5</issue><spage>1352</spage><epage>1357</epage><pages>1352-1357</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>This study was conducted to estimate thyroid dose and the associated risk for thyroid cancer induction from common head and neck computed tomography (CT) examinations during childhood. The Monte Carlo N-particle transport code was employed to simulate the routine CT scanning of the brain, paranasal sinuses, inner ear and neck performed on sequential and/or spiral modes. The mean thyroid dose was calculated using mathematical phantoms representing a newborn infant and children of 1year, 5 years, 10 years and 15 years old. To verify Monte Carlo results, dose measurements were carried out on physical anthropomorphic phantoms using thermoluminescent dosemeters (TLDs). The scattered dose to thyroid from head CT examinations varied from 0.6 mGy to 8.7 mGy depending upon the scanned region, the pediatric patient's age and the acquisition mode used. Primary irradiation of the thyroid gland during CT of the neck resulted in an absorbed dose range of 15.2-52.0 mGy. The mean difference between Monte Carlo calculations and TLD measurements was 11.8%. Thyroid exposure to scattered radiation from head CT scanning is associated with a low but not negligible risk of cancer induction of 4-65 per million patients. Neck CT can result in an increased risk for development of thyroid malignancies up to 390 per million patients.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>17021703</pmid><doi>10.1007/s00330-006-0417-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Cancer Child Child, Preschool Children Computed tomography Head Head & neck cancer Head - diagnostic imaging Head and neck Health risks Humans Infant Infant, Newborn Inner ear Irradiation Malignancy Medical imaging Monte Carlo Method Monte Carlo simulation Neck Neck - diagnostic imaging Neoplasms, Radiation-Induced - etiology Paranasal sinus Paranasal sinuses Pediatrics Phantoms, Imaging Radiation Dosage Radiation measurement Radiometry - methods Risk Risk Assessment Scanning Scattering, Radiation Sinuses Thermoluminescent Dosimetry Thyroid Thyroid cancer Thyroid gland Thyroid Gland - radiation effects Thyroid Neoplasms - etiology Tomography, X-Ray Computed |
| title | Thyroid dose from common head and neck CT examinations in children: is there an excess risk for thyroid cancer induction? |
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