Broad‐Spectrum Antiviral Agents against SARS‐CoV‐2 Variants Inhibit the Conserved Viral Protein Nsp1–RNA Interaction

The ongoing global threats posed by COVID‐19 pandemic, catalyzed by SARS‐CoV‐2, underscores the pressing need for effective antiviral strategies. The viral non‐structural protein 1 (Nsp1) significantly influences pathogenicity by impeding host protein expression and enhancing viral RNA translation t...

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Veröffentlicht in:	Angewandte Chemie 2024-11, Vol.136 (47), p.n/a
Hauptverfasser:	Gi Byun, Wan, Lee, Minha, Ko, Meehyun, Hyae Lee, Ji, Yi, Sihyeong, Lee, JinAh, Kim, Seungtaek, Bum Park, Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Alanine Antiviral Agents COVID-19 Effectiveness Gene expression Medical innovations Molecular docking Mutagenesis Non-Structural Protein 1 Pandemics Pathogenicity Pathogens Proteins Protein–RNA Interaction Sarbecovirus SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases
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