Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol

The development of biosensors is gaining tremendous attention in various fields due to their extraordinary advantages, however, their sensitivity and accuracy are still challenging. Herein, we proposed a novel multifunctional nanocomposite Ce-MOF@PdNPs (MOF = metal-organic framework, PdNPs = Pd nano...

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Veröffentlicht in:Nano research 2024-11, Vol.17 (11), p.9990-9998
Hauptverfasser: Ye, Mingyue, Su, Tingting, Li, Jin, Chen, Xiaowan, Ying, Dichen, Wu, Shijia, Wang, Zhouping, Duan, Nuo
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container_end_page 9998
container_issue 11
container_start_page 9990
container_title Nano research
container_volume 17
creator Ye, Mingyue
Su, Tingting
Li, Jin
Chen, Xiaowan
Ying, Dichen
Wu, Shijia
Wang, Zhouping
Duan, Nuo
description The development of biosensors is gaining tremendous attention in various fields due to their extraordinary advantages, however, their sensitivity and accuracy are still challenging. Herein, we proposed a novel multifunctional nanocomposite Ce-MOF@PdNPs (MOF = metal-organic framework, PdNPs = Pd nanoparticles)-mediated triple-readout aptasensor for accurate and reliable detection of diethylstilbestrol (DES), in which Ce-MOF@PdNPs exhibited excellent peroxidase (POD)-like activity, fluormetric, and electro conductive properties. In addition, enzymes-assisted target recycling amplification was utilized to improve the sensitivity, that is the specific binding of aptamer and DES triggered an Exo III enzyme-assisted recycling reaction. The generated F-DNA was captured by the H3 strand linked to Ce-MOF@PdNPs immobilized on the electrode, exposing cleavage sites and activating the Nt.BbvCI enzyme-assisted recycling reaction, leading to the dissociation of Ce-MOF@PdNPs and a significant reduced electrochemical signal. The collected Ce-MOF@PdNPs solution also induced a proportional change in the color and fluorescence, achieving a colorimetric and fluormetric detection functionality. The detection limit under colorimetric mode was 0.16 and 0.76 ng/mL under fluorescence mode, and 0.87 pg/mL under electrochemical mode. This triple-readout aptasensor exhibits high sensitivity, selectivity and accuracy, providing a new idea for designing novel biosensing platforms for veterinary drug residue detection.
doi_str_mv 10.1007/s12274-024-6951-4
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ispartof Nano research, 2024-11, Vol.17 (11), p.9990-9998
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1998-0000
language eng
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subjects Aptamers
Atomic/Molecular Structure and Spectra
Biomedicine
Biosensors
Biotechnology
Chemistry and Materials Science
Colorimetry
Condensed Matter Physics
Diethylstilbestrol
Electrochemistry
Enzymes
Fluorescence
Materials Science
Metal-organic frameworks
Nanocomposites
Nanoparticles
Nanotechnology
Palladium
Peroxidase
Recycling
Research Article
Sensitivity
title Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol
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