Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol
The development of biosensors is gaining tremendous attention in various fields due to their extraordinary advantages, however, their sensitivity and accuracy are still challenging. Herein, we proposed a novel multifunctional nanocomposite Ce-MOF@PdNPs (MOF = metal-organic framework, PdNPs = Pd nano...
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Veröffentlicht in: | Nano research 2024-11, Vol.17 (11), p.9990-9998 |
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description | The development of biosensors is gaining tremendous attention in various fields due to their extraordinary advantages, however, their sensitivity and accuracy are still challenging. Herein, we proposed a novel multifunctional nanocomposite Ce-MOF@PdNPs (MOF = metal-organic framework, PdNPs = Pd nanoparticles)-mediated triple-readout aptasensor for accurate and reliable detection of diethylstilbestrol (DES), in which Ce-MOF@PdNPs exhibited excellent peroxidase (POD)-like activity, fluormetric, and electro conductive properties. In addition, enzymes-assisted target recycling amplification was utilized to improve the sensitivity, that is the specific binding of aptamer and DES triggered an Exo III enzyme-assisted recycling reaction. The generated F-DNA was captured by the H3 strand linked to Ce-MOF@PdNPs immobilized on the electrode, exposing cleavage sites and activating the Nt.BbvCI enzyme-assisted recycling reaction, leading to the dissociation of Ce-MOF@PdNPs and a significant reduced electrochemical signal. The collected Ce-MOF@PdNPs solution also induced a proportional change in the color and fluorescence, achieving a colorimetric and fluormetric detection functionality. The detection limit under colorimetric mode was 0.16 and 0.76 ng/mL under fluorescence mode, and 0.87 pg/mL under electrochemical mode. This triple-readout aptasensor exhibits high sensitivity, selectivity and accuracy, providing a new idea for designing novel biosensing platforms for veterinary drug residue detection. |
doi_str_mv | 10.1007/s12274-024-6951-4 |
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Herein, we proposed a novel multifunctional nanocomposite Ce-MOF@PdNPs (MOF = metal-organic framework, PdNPs = Pd nanoparticles)-mediated triple-readout aptasensor for accurate and reliable detection of diethylstilbestrol (DES), in which Ce-MOF@PdNPs exhibited excellent peroxidase (POD)-like activity, fluormetric, and electro conductive properties. In addition, enzymes-assisted target recycling amplification was utilized to improve the sensitivity, that is the specific binding of aptamer and DES triggered an Exo III enzyme-assisted recycling reaction. The generated F-DNA was captured by the H3 strand linked to Ce-MOF@PdNPs immobilized on the electrode, exposing cleavage sites and activating the Nt.BbvCI enzyme-assisted recycling reaction, leading to the dissociation of Ce-MOF@PdNPs and a significant reduced electrochemical signal. The collected Ce-MOF@PdNPs solution also induced a proportional change in the color and fluorescence, achieving a colorimetric and fluormetric detection functionality. The detection limit under colorimetric mode was 0.16 and 0.76 ng/mL under fluorescence mode, and 0.87 pg/mL under electrochemical mode. This triple-readout aptasensor exhibits high sensitivity, selectivity and accuracy, providing a new idea for designing novel biosensing platforms for veterinary drug residue detection.</description><identifier>ISSN: 1998-0124</identifier><identifier>EISSN: 1998-0000</identifier><identifier>DOI: 10.1007/s12274-024-6951-4</identifier><language>eng</language><publisher>Beijing: Tsinghua University Press</publisher><subject>Aptamers ; Atomic/Molecular Structure and Spectra ; Biomedicine ; Biosensors ; Biotechnology ; Chemistry and Materials Science ; Colorimetry ; Condensed Matter Physics ; Diethylstilbestrol ; Electrochemistry ; Enzymes ; Fluorescence ; Materials Science ; Metal-organic frameworks ; Nanocomposites ; Nanoparticles ; Nanotechnology ; Palladium ; Peroxidase ; Recycling ; Research Article ; Sensitivity</subject><ispartof>Nano research, 2024-11, Vol.17 (11), p.9990-9998</ispartof><rights>Tsinghua University Press 2024</rights><rights>Tsinghua University Press 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c198t-af4573717eb2c957d2b31983a5be9ced4d65afb81ea27f594293648ab3518d8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12274-024-6951-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12274-024-6951-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Ye, Mingyue</creatorcontrib><creatorcontrib>Su, Tingting</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>Chen, Xiaowan</creatorcontrib><creatorcontrib>Ying, Dichen</creatorcontrib><creatorcontrib>Wu, Shijia</creatorcontrib><creatorcontrib>Wang, Zhouping</creatorcontrib><creatorcontrib>Duan, Nuo</creatorcontrib><title>Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol</title><title>Nano research</title><addtitle>Nano Res</addtitle><description>The development of biosensors is gaining tremendous attention in various fields due to their extraordinary advantages, however, their sensitivity and accuracy are still challenging. Herein, we proposed a novel multifunctional nanocomposite Ce-MOF@PdNPs (MOF = metal-organic framework, PdNPs = Pd nanoparticles)-mediated triple-readout aptasensor for accurate and reliable detection of diethylstilbestrol (DES), in which Ce-MOF@PdNPs exhibited excellent peroxidase (POD)-like activity, fluormetric, and electro conductive properties. In addition, enzymes-assisted target recycling amplification was utilized to improve the sensitivity, that is the specific binding of aptamer and DES triggered an Exo III enzyme-assisted recycling reaction. The generated F-DNA was captured by the H3 strand linked to Ce-MOF@PdNPs immobilized on the electrode, exposing cleavage sites and activating the Nt.BbvCI enzyme-assisted recycling reaction, leading to the dissociation of Ce-MOF@PdNPs and a significant reduced electrochemical signal. The collected Ce-MOF@PdNPs solution also induced a proportional change in the color and fluorescence, achieving a colorimetric and fluormetric detection functionality. The detection limit under colorimetric mode was 0.16 and 0.76 ng/mL under fluorescence mode, and 0.87 pg/mL under electrochemical mode. This triple-readout aptasensor exhibits high sensitivity, selectivity and accuracy, providing a new idea for designing novel biosensing platforms for veterinary drug residue detection.</description><subject>Aptamers</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Biomedicine</subject><subject>Biosensors</subject><subject>Biotechnology</subject><subject>Chemistry and Materials Science</subject><subject>Colorimetry</subject><subject>Condensed Matter Physics</subject><subject>Diethylstilbestrol</subject><subject>Electrochemistry</subject><subject>Enzymes</subject><subject>Fluorescence</subject><subject>Materials Science</subject><subject>Metal-organic frameworks</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Palladium</subject><subject>Peroxidase</subject><subject>Recycling</subject><subject>Research Article</subject><subject>Sensitivity</subject><issn>1998-0124</issn><issn>1998-0000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kM1OAyEURidGE7X6AO5IXI8ODNOZ2Wka_5LWdqFrwsDF0uBQgdH0OXxhb63GlWwg3O87NzlZdkaLC1oU9WWkjNU8LxjPx21Fc76XHdG2bfICz_7vmzJ-mB3HuCqKMaO8Oco-Z4NL1gy9Stb30pEJ5LP57dVCPy4i-bBpSZR3PthXSMEqYtzgA0QFfSLgQKXg1RJercKqRMa7TRtifCCIDTJCHy1-ApG9xrkagkxANCT43ke8IdpCWm5cTNZ1EJHnTrIDI12E0597lD3f3jxN7vPp_O5hcj3NFW2blEvDq7qsaQ0dU21Va9aVOChl1UGrQHM9rqTpGgqS1aZqOWvLMW9kV1a00Y0uR9n5jrsO_m3A3WLlh4ASoijRFEN4XWKK7lIq-BgDGLFGGzJsBC3E1r3YuRfoXmzdC44dtutEzPYvEP7I_5e-AKjti10</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Ye, Mingyue</creator><creator>Su, Tingting</creator><creator>Li, Jin</creator><creator>Chen, Xiaowan</creator><creator>Ying, Dichen</creator><creator>Wu, Shijia</creator><creator>Wang, Zhouping</creator><creator>Duan, Nuo</creator><general>Tsinghua University Press</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>P64</scope></search><sort><creationdate>20241101</creationdate><title>Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol</title><author>Ye, Mingyue ; 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Herein, we proposed a novel multifunctional nanocomposite Ce-MOF@PdNPs (MOF = metal-organic framework, PdNPs = Pd nanoparticles)-mediated triple-readout aptasensor for accurate and reliable detection of diethylstilbestrol (DES), in which Ce-MOF@PdNPs exhibited excellent peroxidase (POD)-like activity, fluormetric, and electro conductive properties. In addition, enzymes-assisted target recycling amplification was utilized to improve the sensitivity, that is the specific binding of aptamer and DES triggered an Exo III enzyme-assisted recycling reaction. The generated F-DNA was captured by the H3 strand linked to Ce-MOF@PdNPs immobilized on the electrode, exposing cleavage sites and activating the Nt.BbvCI enzyme-assisted recycling reaction, leading to the dissociation of Ce-MOF@PdNPs and a significant reduced electrochemical signal. The collected Ce-MOF@PdNPs solution also induced a proportional change in the color and fluorescence, achieving a colorimetric and fluormetric detection functionality. The detection limit under colorimetric mode was 0.16 and 0.76 ng/mL under fluorescence mode, and 0.87 pg/mL under electrochemical mode. This triple-readout aptasensor exhibits high sensitivity, selectivity and accuracy, providing a new idea for designing novel biosensing platforms for veterinary drug residue detection.</abstract><cop>Beijing</cop><pub>Tsinghua University Press</pub><doi>10.1007/s12274-024-6951-4</doi><tpages>9</tpages></addata></record> |
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subjects | Aptamers Atomic/Molecular Structure and Spectra Biomedicine Biosensors Biotechnology Chemistry and Materials Science Colorimetry Condensed Matter Physics Diethylstilbestrol Electrochemistry Enzymes Fluorescence Materials Science Metal-organic frameworks Nanocomposites Nanoparticles Nanotechnology Palladium Peroxidase Recycling Research Article Sensitivity |
title | Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol |
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