Engineering microbes for 1,3‐propanediol production
1,3‐Propanediol (1,3‐PDO) has multiple practical applications, for example as an antifreeze and protective agent and as a monomer of partially renewable polyester and polyurethane. The main method for 1,3‐PDO production is currently microbial fermentation. Bio‐based 1,3‐PDO can use renewable materia...
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| Veröffentlicht in: | Biofuels, bioproducts and biorefining bioproducts and biorefining, 2024-11, Vol.18 (6), p.2116-2131 |
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| creator | Du, Ruotong Ling, Hongzhi Cheng, Keke |
| description | 1,3‐Propanediol (1,3‐PDO) has multiple practical applications, for example as an antifreeze and protective agent and as a monomer of partially renewable polyester and polyurethane. The main method for 1,3‐PDO production is currently microbial fermentation. Bio‐based 1,3‐PDO can use renewable materials as substrates, and the process is mild and environmentally friendly.
Genetic engineering of microorganisms is crucial to achieve substrate diversity, reduce byproducts to decrease production costs, and facilitate the downstream processing of 1,3‐PDO. This paper reviews the metabolic engineering of 1,3‐PDO in natural and non‐natural producers. In particular, it discusses current progress using non‐natural synthetic pathways to obtain 1,3‐propanediol.
Finally, strategies such as integrated production with other high‐value‐added products are proposed for successful commercialization. |
| doi_str_mv | 10.1002/bbb.2672 |
| format | Article |
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Genetic engineering of microorganisms is crucial to achieve substrate diversity, reduce byproducts to decrease production costs, and facilitate the downstream processing of 1,3‐PDO. This paper reviews the metabolic engineering of 1,3‐PDO in natural and non‐natural producers. In particular, it discusses current progress using non‐natural synthetic pathways to obtain 1,3‐propanediol.
Finally, strategies such as integrated production with other high‐value‐added products are proposed for successful commercialization.</description><identifier>ISSN: 1932-104X</identifier><identifier>EISSN: 1932-1031</identifier><identifier>DOI: 10.1002/bbb.2672</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>1,3-Propanediol ; 1,3‐propanediol synthesis ; Antifreezes ; biosynthesis strategy ; Commercialization ; Fermentation ; Genetic diversity ; Genetic engineering ; Marketing ; Metabolic engineering ; microbial fermentation ; Microorganisms ; Operating costs ; Polyurethane ; Polyurethane resins ; Production costs ; Renewable resources</subject><ispartof>Biofuels, bioproducts and biorefining, 2024-11, Vol.18 (6), p.2116-2131</ispartof><rights>2024 Society of Industrial Chemistry and John Wiley & Sons Ltd.</rights><rights>2024 Society of Chemical Industry and John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1842-4ba78c21c08335aeeadf7424cc5a121fb2fc103f26dfaf40054e33f4693552e23</cites><orcidid>0000-0002-1520-5477</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbbb.2672$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbbb.2672$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Du, Ruotong</creatorcontrib><creatorcontrib>Ling, Hongzhi</creatorcontrib><creatorcontrib>Cheng, Keke</creatorcontrib><title>Engineering microbes for 1,3‐propanediol production</title><title>Biofuels, bioproducts and biorefining</title><description>1,3‐Propanediol (1,3‐PDO) has multiple practical applications, for example as an antifreeze and protective agent and as a monomer of partially renewable polyester and polyurethane. The main method for 1,3‐PDO production is currently microbial fermentation. Bio‐based 1,3‐PDO can use renewable materials as substrates, and the process is mild and environmentally friendly.
Genetic engineering of microorganisms is crucial to achieve substrate diversity, reduce byproducts to decrease production costs, and facilitate the downstream processing of 1,3‐PDO. This paper reviews the metabolic engineering of 1,3‐PDO in natural and non‐natural producers. In particular, it discusses current progress using non‐natural synthetic pathways to obtain 1,3‐propanediol.
Finally, strategies such as integrated production with other high‐value‐added products are proposed for successful commercialization.</description><subject>1,3-Propanediol</subject><subject>1,3‐propanediol synthesis</subject><subject>Antifreezes</subject><subject>biosynthesis strategy</subject><subject>Commercialization</subject><subject>Fermentation</subject><subject>Genetic diversity</subject><subject>Genetic engineering</subject><subject>Marketing</subject><subject>Metabolic engineering</subject><subject>microbial fermentation</subject><subject>Microorganisms</subject><subject>Operating costs</subject><subject>Polyurethane</subject><subject>Polyurethane resins</subject><subject>Production costs</subject><subject>Renewable resources</subject><issn>1932-104X</issn><issn>1932-1031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kM1KAzEUhYMoWKvgIwy4ceHU5N5kOrO0pf5AwY2Cu5BkkpIynalJB-nOR-gz-iSmVty5umfxcc_HIeSS0RGjFG611iMoxnBEBqxCyBlFdvyX-dspOYtxSakoBBcDImbtwrfWBt8uspU3odM2Zq4LGbvBr8_dOnRr1drad02Wct2bje_ac3LiVBPtxe8dktf72cv0MZ8_PzxN7-a5YSWHnGs1Lg0wQ0tEoaxVtRtz4MYIxYA5Dc4kPwdF7ZTjSYpbRMeLCoUACzgkV4e_qfq9t3Ejl10f2lQpkQFWtALERF0fqGQfY7BOroNfqbCVjMr9KDKNIvejJDQ_oB--sdt_OTmZTH74b677YhI</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Du, Ruotong</creator><creator>Ling, Hongzhi</creator><creator>Cheng, Keke</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7TA</scope><scope>7TB</scope><scope>7TN</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L.F</scope><scope>L.G</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0002-1520-5477</orcidid></search><sort><creationdate>202411</creationdate><title>Engineering microbes for 1,3‐propanediol production</title><author>Du, Ruotong ; Ling, Hongzhi ; Cheng, Keke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1842-4ba78c21c08335aeeadf7424cc5a121fb2fc103f26dfaf40054e33f4693552e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>1,3-Propanediol</topic><topic>1,3‐propanediol synthesis</topic><topic>Antifreezes</topic><topic>biosynthesis strategy</topic><topic>Commercialization</topic><topic>Fermentation</topic><topic>Genetic diversity</topic><topic>Genetic engineering</topic><topic>Marketing</topic><topic>Metabolic engineering</topic><topic>microbial fermentation</topic><topic>Microorganisms</topic><topic>Operating costs</topic><topic>Polyurethane</topic><topic>Polyurethane resins</topic><topic>Production costs</topic><topic>Renewable resources</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Ruotong</creatorcontrib><creatorcontrib>Ling, Hongzhi</creatorcontrib><creatorcontrib>Cheng, Keke</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Biofuels, bioproducts and biorefining</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Ruotong</au><au>Ling, Hongzhi</au><au>Cheng, Keke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering microbes for 1,3‐propanediol production</atitle><jtitle>Biofuels, bioproducts and biorefining</jtitle><date>2024-11</date><risdate>2024</risdate><volume>18</volume><issue>6</issue><spage>2116</spage><epage>2131</epage><pages>2116-2131</pages><issn>1932-104X</issn><eissn>1932-1031</eissn><abstract>1,3‐Propanediol (1,3‐PDO) has multiple practical applications, for example as an antifreeze and protective agent and as a monomer of partially renewable polyester and polyurethane. The main method for 1,3‐PDO production is currently microbial fermentation. Bio‐based 1,3‐PDO can use renewable materials as substrates, and the process is mild and environmentally friendly.
Genetic engineering of microorganisms is crucial to achieve substrate diversity, reduce byproducts to decrease production costs, and facilitate the downstream processing of 1,3‐PDO. This paper reviews the metabolic engineering of 1,3‐PDO in natural and non‐natural producers. In particular, it discusses current progress using non‐natural synthetic pathways to obtain 1,3‐propanediol.
Finally, strategies such as integrated production with other high‐value‐added products are proposed for successful commercialization.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/bbb.2672</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-1520-5477</orcidid></addata></record> |
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| subjects | 1,3-Propanediol 1,3‐propanediol synthesis Antifreezes biosynthesis strategy Commercialization Fermentation Genetic diversity Genetic engineering Marketing Metabolic engineering microbial fermentation Microorganisms Operating costs Polyurethane Polyurethane resins Production costs Renewable resources |
| title | Engineering microbes for 1,3‐propanediol production |
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