Adiponectin Prolongs Repolarization in Rat Ventricular Myocardium
Adiponectin confers protective effects in the cardiovascular system. However, its effects on cardiac electrophysiological characteristics are unclear. The aim of the present study was evaluating myocardial electrophysiological parameters under chronic adiponectin treatment in rats. Epicardial mappin...
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| Veröffentlicht in: | Journal of evolutionary biochemistry and physiology 2024-09, Vol.60 (5), p.1685-1692 |
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| creator | Sedyakina, E. N. Tsvetkova, A. S. Polyakova, E. A. Galagudza, M. M. Sonin, D. L. Azarov, J. E. Ovechkin, A. O. |
| description | Adiponectin confers protective effects in the cardiovascular system. However, its effects on cardiac electrophysiological characteristics are unclear. The aim of the present study was evaluating myocardial electrophysiological parameters under chronic adiponectin treatment in rats. Epicardial mapping in 64 leads along with ECG recording were performed in the anaesthetized rats in 1 week after the placement of subcutaneous osmotic mini-pumps. The adiponectin group (
n
= 9) received a pump containing adiponectin, and the control group (
n
= 7) received an empty pump (sham surgery). In each epicardial lead, the activation time (AT), the end of repolarization time (RT), activation–repolarization intervals (ARI) and dispersion of repolarization (DOR) were determined. The rats treated with adiponectin showed prolonged ARIs in the left ventricle and the increased DOR as compared to the controls [20.82 (IQR 18.43–27.29) vs 14.36 (IQR 12.09–16.67),
р
= 0.02] and [35.1 (IQR 30.5–47.5) vs 26.75 (IQR 26.63–26.75),
р
= 0.03], in ms, respectively. At the same time, in the right ventricle similar parameters did not differ between groups. In line with the epicardial mapping parameters, QT and Tpeak-Tend intervals in the body surface ECG were prolonged in the adiponectin-treated animals as compared to the controls [0.07 (IQR 0.06–0.08) vs 0.06 (IQR 0.05–0.06),
р
= 0.02] and [0.04 (IQR 0.03–0.04) vs 0.02 (IQR 0.01–0.03),
р
= 0.009], in sec, respectively. Hyperadiponectinemia was associated with prolongation of ventricular repolarization. |
| doi_str_mv | 10.1134/S0022093024050028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3122603090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3122603090</sourcerecordid><originalsourceid>FETCH-LOGICAL-c198t-3ec72fb503b27de22cfd9f18593d2e65d7a830e1df81ddd6830687c211ae0c823</originalsourceid><addsrcrecordid>eNp1kEtLxDAUhYMoOI7-AHcF19Wbmz7S5TD4ghFlfGxLJkmHDJ2kJu1i_PWmVHAhru69fOecC4eQSwrXlLLs5hUAESoGmEEed35EZrQAnjIEPCazEacjPyVnIewAoOJZNiOLhTKds1r2xiYv3rXObkOy1p1rhTdfojfOJhGtRZ98aNt7I4dIkqeDk8IrM-zPyUkj2qAvfuacvN_dvi0f0tXz_eNysUolrXifMi1LbDY5sA2WSiPKRlUN5XnFFOoiV6XgDDRVDadKqSIeBS8lUio0SI5sTq6m3M67z0GHvt65wdv4smYUsQAGFUQVnVTSuxC8burOm73wh5pCPTZV_2kqenDyhKi1W-1_k_83fQN3RmnU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3122603090</pqid></control><display><type>article</type><title>Adiponectin Prolongs Repolarization in Rat Ventricular Myocardium</title><source>SpringerNature Journals</source><creator>Sedyakina, E. N. ; Tsvetkova, A. S. ; Polyakova, E. A. ; Galagudza, M. M. ; Sonin, D. L. ; Azarov, J. E. ; Ovechkin, A. O.</creator><creatorcontrib>Sedyakina, E. N. ; Tsvetkova, A. S. ; Polyakova, E. A. ; Galagudza, M. M. ; Sonin, D. L. ; Azarov, J. E. ; Ovechkin, A. O.</creatorcontrib><description>Adiponectin confers protective effects in the cardiovascular system. However, its effects on cardiac electrophysiological characteristics are unclear. The aim of the present study was evaluating myocardial electrophysiological parameters under chronic adiponectin treatment in rats. Epicardial mapping in 64 leads along with ECG recording were performed in the anaesthetized rats in 1 week after the placement of subcutaneous osmotic mini-pumps. The adiponectin group (
n
= 9) received a pump containing adiponectin, and the control group (
n
= 7) received an empty pump (sham surgery). In each epicardial lead, the activation time (AT), the end of repolarization time (RT), activation–repolarization intervals (ARI) and dispersion of repolarization (DOR) were determined. The rats treated with adiponectin showed prolonged ARIs in the left ventricle and the increased DOR as compared to the controls [20.82 (IQR 18.43–27.29) vs 14.36 (IQR 12.09–16.67),
р
= 0.02] and [35.1 (IQR 30.5–47.5) vs 26.75 (IQR 26.63–26.75),
р
= 0.03], in ms, respectively. At the same time, in the right ventricle similar parameters did not differ between groups. In line with the epicardial mapping parameters, QT and Tpeak-Tend intervals in the body surface ECG were prolonged in the adiponectin-treated animals as compared to the controls [0.07 (IQR 0.06–0.08) vs 0.06 (IQR 0.05–0.06),
р
= 0.02] and [0.04 (IQR 0.03–0.04) vs 0.02 (IQR 0.01–0.03),
р
= 0.009], in sec, respectively. Hyperadiponectinemia was associated with prolongation of ventricular repolarization.</description><identifier>ISSN: 0022-0930</identifier><identifier>EISSN: 1608-3202</identifier><identifier>DOI: 10.1134/S0022093024050028</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Adiponectin ; Animal Physiology ; Biochemistry ; Biomedical and Life Sciences ; Cardiovascular system ; EKG ; Evolutionary Biology ; Experimental Papers ; Life Sciences ; Mapping ; Myocardium ; Ventricle</subject><ispartof>Journal of evolutionary biochemistry and physiology, 2024-09, Vol.60 (5), p.1685-1692</ispartof><rights>Pleiades Publishing, Ltd. 2024</rights><rights>Pleiades Publishing, Ltd. 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c198t-3ec72fb503b27de22cfd9f18593d2e65d7a830e1df81ddd6830687c211ae0c823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0022093024050028$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0022093024050028$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Sedyakina, E. N.</creatorcontrib><creatorcontrib>Tsvetkova, A. S.</creatorcontrib><creatorcontrib>Polyakova, E. A.</creatorcontrib><creatorcontrib>Galagudza, M. M.</creatorcontrib><creatorcontrib>Sonin, D. L.</creatorcontrib><creatorcontrib>Azarov, J. E.</creatorcontrib><creatorcontrib>Ovechkin, A. O.</creatorcontrib><title>Adiponectin Prolongs Repolarization in Rat Ventricular Myocardium</title><title>Journal of evolutionary biochemistry and physiology</title><addtitle>J Evol Biochem Phys</addtitle><description>Adiponectin confers protective effects in the cardiovascular system. However, its effects on cardiac electrophysiological characteristics are unclear. The aim of the present study was evaluating myocardial electrophysiological parameters under chronic adiponectin treatment in rats. Epicardial mapping in 64 leads along with ECG recording were performed in the anaesthetized rats in 1 week after the placement of subcutaneous osmotic mini-pumps. The adiponectin group (
n
= 9) received a pump containing adiponectin, and the control group (
n
= 7) received an empty pump (sham surgery). In each epicardial lead, the activation time (AT), the end of repolarization time (RT), activation–repolarization intervals (ARI) and dispersion of repolarization (DOR) were determined. The rats treated with adiponectin showed prolonged ARIs in the left ventricle and the increased DOR as compared to the controls [20.82 (IQR 18.43–27.29) vs 14.36 (IQR 12.09–16.67),
р
= 0.02] and [35.1 (IQR 30.5–47.5) vs 26.75 (IQR 26.63–26.75),
р
= 0.03], in ms, respectively. At the same time, in the right ventricle similar parameters did not differ between groups. In line with the epicardial mapping parameters, QT and Tpeak-Tend intervals in the body surface ECG were prolonged in the adiponectin-treated animals as compared to the controls [0.07 (IQR 0.06–0.08) vs 0.06 (IQR 0.05–0.06),
р
= 0.02] and [0.04 (IQR 0.03–0.04) vs 0.02 (IQR 0.01–0.03),
р
= 0.009], in sec, respectively. Hyperadiponectinemia was associated with prolongation of ventricular repolarization.</description><subject>Adiponectin</subject><subject>Animal Physiology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiovascular system</subject><subject>EKG</subject><subject>Evolutionary Biology</subject><subject>Experimental Papers</subject><subject>Life Sciences</subject><subject>Mapping</subject><subject>Myocardium</subject><subject>Ventricle</subject><issn>0022-0930</issn><issn>1608-3202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLxDAUhYMoOI7-AHcF19Wbmz7S5TD4ghFlfGxLJkmHDJ2kJu1i_PWmVHAhru69fOecC4eQSwrXlLLs5hUAESoGmEEed35EZrQAnjIEPCazEacjPyVnIewAoOJZNiOLhTKds1r2xiYv3rXObkOy1p1rhTdfojfOJhGtRZ98aNt7I4dIkqeDk8IrM-zPyUkj2qAvfuacvN_dvi0f0tXz_eNysUolrXifMi1LbDY5sA2WSiPKRlUN5XnFFOoiV6XgDDRVDadKqSIeBS8lUio0SI5sTq6m3M67z0GHvt65wdv4smYUsQAGFUQVnVTSuxC8burOm73wh5pCPTZV_2kqenDyhKi1W-1_k_83fQN3RmnU</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Sedyakina, E. N.</creator><creator>Tsvetkova, A. S.</creator><creator>Polyakova, E. A.</creator><creator>Galagudza, M. M.</creator><creator>Sonin, D. L.</creator><creator>Azarov, J. E.</creator><creator>Ovechkin, A. O.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>20240901</creationdate><title>Adiponectin Prolongs Repolarization in Rat Ventricular Myocardium</title><author>Sedyakina, E. N. ; Tsvetkova, A. S. ; Polyakova, E. A. ; Galagudza, M. M. ; Sonin, D. L. ; Azarov, J. E. ; Ovechkin, A. O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c198t-3ec72fb503b27de22cfd9f18593d2e65d7a830e1df81ddd6830687c211ae0c823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adiponectin</topic><topic>Animal Physiology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cardiovascular system</topic><topic>EKG</topic><topic>Evolutionary Biology</topic><topic>Experimental Papers</topic><topic>Life Sciences</topic><topic>Mapping</topic><topic>Myocardium</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedyakina, E. N.</creatorcontrib><creatorcontrib>Tsvetkova, A. S.</creatorcontrib><creatorcontrib>Polyakova, E. A.</creatorcontrib><creatorcontrib>Galagudza, M. M.</creatorcontrib><creatorcontrib>Sonin, D. L.</creatorcontrib><creatorcontrib>Azarov, J. E.</creatorcontrib><creatorcontrib>Ovechkin, A. O.</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of evolutionary biochemistry and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedyakina, E. N.</au><au>Tsvetkova, A. S.</au><au>Polyakova, E. A.</au><au>Galagudza, M. M.</au><au>Sonin, D. L.</au><au>Azarov, J. E.</au><au>Ovechkin, A. O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiponectin Prolongs Repolarization in Rat Ventricular Myocardium</atitle><jtitle>Journal of evolutionary biochemistry and physiology</jtitle><stitle>J Evol Biochem Phys</stitle><date>2024-09-01</date><risdate>2024</risdate><volume>60</volume><issue>5</issue><spage>1685</spage><epage>1692</epage><pages>1685-1692</pages><issn>0022-0930</issn><eissn>1608-3202</eissn><abstract>Adiponectin confers protective effects in the cardiovascular system. However, its effects on cardiac electrophysiological characteristics are unclear. The aim of the present study was evaluating myocardial electrophysiological parameters under chronic adiponectin treatment in rats. Epicardial mapping in 64 leads along with ECG recording were performed in the anaesthetized rats in 1 week after the placement of subcutaneous osmotic mini-pumps. The adiponectin group (
n
= 9) received a pump containing adiponectin, and the control group (
n
= 7) received an empty pump (sham surgery). In each epicardial lead, the activation time (AT), the end of repolarization time (RT), activation–repolarization intervals (ARI) and dispersion of repolarization (DOR) were determined. The rats treated with adiponectin showed prolonged ARIs in the left ventricle and the increased DOR as compared to the controls [20.82 (IQR 18.43–27.29) vs 14.36 (IQR 12.09–16.67),
р
= 0.02] and [35.1 (IQR 30.5–47.5) vs 26.75 (IQR 26.63–26.75),
р
= 0.03], in ms, respectively. At the same time, in the right ventricle similar parameters did not differ between groups. In line with the epicardial mapping parameters, QT and Tpeak-Tend intervals in the body surface ECG were prolonged in the adiponectin-treated animals as compared to the controls [0.07 (IQR 0.06–0.08) vs 0.06 (IQR 0.05–0.06),
р
= 0.02] and [0.04 (IQR 0.03–0.04) vs 0.02 (IQR 0.01–0.03),
р
= 0.009], in sec, respectively. Hyperadiponectinemia was associated with prolongation of ventricular repolarization.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0022093024050028</doi><tpages>8</tpages></addata></record> |
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| subjects | Adiponectin Animal Physiology Biochemistry Biomedical and Life Sciences Cardiovascular system EKG Evolutionary Biology Experimental Papers Life Sciences Mapping Myocardium Ventricle |
| title | Adiponectin Prolongs Repolarization in Rat Ventricular Myocardium |
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