Iranian patients with diabetes and COVID-19-associated mucormycosis: Characteristics, manifestations, and mortality risk factors
Objective This study evaluated the mortality risk factors in Iranian patients with diabetes mellitus (DM) and COVID-19-associated mucormycosis (CAM). Methods This retrospective study was conducted on confirmed CAM cases with DM. Only patients with a confirmed history of COVID-19 within the last 3 mo...
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| Veröffentlicht in: | International journal of diabetes in developing countries 2024, Vol.44 (4), p.704-710 |
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| creator | Salehi, Mohammadreza Esteghamati, Alireza Khodavaisy, Sadegh Khajavi Rad, Nasim Abdollahi, Alireza Alemzadeh, Sayyed Amirsina Nasserisina, Sadaf Tabari, Azin Pakdel, Farzad Mohammadi, Saeed Joorabloo, Neda Abdorahimi, Mahsa Shavandi, Mehrdad Rabizadeh, Soghra |
| description | Objective
This study evaluated the mortality risk factors in Iranian patients with diabetes mellitus (DM) and COVID-19-associated mucormycosis (CAM).
Methods
This retrospective study was conducted on confirmed CAM cases with DM. Only patients with a confirmed history of COVID-19 within the last 3 months were included. The patients were divided into the survived and deceased groups, and each group’s characteristics were studied and compared. Patients were also studied according to their DM status (known or unknown case).
Results
A total of 106 patients were included. The mortality rate was 25.5%. The most common underlying disease (hypertension, 41.5%) was significantly higher in the deceased group. Sixty-five patients (62.5%) were known cases of DM. The mean duration of DM was 12.46 years. There was a significant relationship between the DM history and mortality rate (84.6% vs. 15.4%,
p
= 0.007). The history of ICU admission was 8 times higher in unknown DM patients (
p
= 0.011, OR = 8.000, CI = 1.60–39.95). The mean HbA1C was significantly different in known DM cases (9.36 ± 2.03 vs. 8.02 ± 2.40,
p
= 0.004). The mean first day FBS, mean first BS in emergency room, and mean FBS on the first hospitalization week were 171, 202, and 167.2 mg/dL, respectively. Although mortality was significantly related to hyperglycemic state of fasting and non-fasting BS levels (
p |
| doi_str_mv | 10.1007/s13410-024-01309-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3122603015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3122603015</sourcerecordid><originalsourceid>FETCH-LOGICAL-c270t-1c96041a5addcfc6afc9941f34eaa33780fd5921f184c1a7e9429357f73297823</originalsourceid><addsrcrecordid>eNp9kMFuEzEQhi1EJULhBThZ4orbsWc3u-aGQksjVeoFuFqD16Yu3XXwOKpy49FxCBI3TqOR_u-b0S_EGw0XGmC4ZI2dBgWmU6ARrOqfiZW2dlQ4onkuVmAHVGgRXoiXzA8AfW_WuBK_toWWRIvcUU1hqSyfUr2XU6JvoQaWtExyc_d1-1Fpq4g5-0Q1THLe-1zmg8-c-L3c3FMhX0NJXJPnd3Ju0hi4Nmle2n7UzLlUekz1IFvsh4wNyIVfibNIjxxe_53n4sv11efNjbq9-7TdfLhV3gxQlfZ2DZ2mnqbJR7-m6K3tdMQuECEOI8Spt0ZHPXZe0xBsZyz2QxzQ2GE0eC7enry7kn_u22vuIe_L0k461MasAUH3LWVOKV8ycwnR7UqaqRycBnds2p2adq1p96dpd4TwBHELL99D-af-D_Ub1c-CWg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3122603015</pqid></control><display><type>article</type><title>Iranian patients with diabetes and COVID-19-associated mucormycosis: Characteristics, manifestations, and mortality risk factors</title><source>Springer Journals</source><creator>Salehi, Mohammadreza ; Esteghamati, Alireza ; Khodavaisy, Sadegh ; Khajavi Rad, Nasim ; Abdollahi, Alireza ; Alemzadeh, Sayyed Amirsina ; Nasserisina, Sadaf ; Tabari, Azin ; Pakdel, Farzad ; Mohammadi, Saeed ; Joorabloo, Neda ; Abdorahimi, Mahsa ; Shavandi, Mehrdad ; Rabizadeh, Soghra</creator><creatorcontrib>Salehi, Mohammadreza ; Esteghamati, Alireza ; Khodavaisy, Sadegh ; Khajavi Rad, Nasim ; Abdollahi, Alireza ; Alemzadeh, Sayyed Amirsina ; Nasserisina, Sadaf ; Tabari, Azin ; Pakdel, Farzad ; Mohammadi, Saeed ; Joorabloo, Neda ; Abdorahimi, Mahsa ; Shavandi, Mehrdad ; Rabizadeh, Soghra</creatorcontrib><description>Objective
This study evaluated the mortality risk factors in Iranian patients with diabetes mellitus (DM) and COVID-19-associated mucormycosis (CAM).
Methods
This retrospective study was conducted on confirmed CAM cases with DM. Only patients with a confirmed history of COVID-19 within the last 3 months were included. The patients were divided into the survived and deceased groups, and each group’s characteristics were studied and compared. Patients were also studied according to their DM status (known or unknown case).
Results
A total of 106 patients were included. The mortality rate was 25.5%. The most common underlying disease (hypertension, 41.5%) was significantly higher in the deceased group. Sixty-five patients (62.5%) were known cases of DM. The mean duration of DM was 12.46 years. There was a significant relationship between the DM history and mortality rate (84.6% vs. 15.4%,
p
= 0.007). The history of ICU admission was 8 times higher in unknown DM patients (
p
= 0.011, OR = 8.000, CI = 1.60–39.95). The mean HbA1C was significantly different in known DM cases (9.36 ± 2.03 vs. 8.02 ± 2.40,
p
= 0.004). The mean first day FBS, mean first BS in emergency room, and mean FBS on the first hospitalization week were 171, 202, and 167.2 mg/dL, respectively. Although mortality was significantly related to hyperglycemic state of fasting and non-fasting BS levels (
p
< 0.05), it was not related to HbA1C.
Conclusion
Patients with diabetes and COVID-19 had uncontrolled fasting and non-fasting glucose levels during mucormycosis episode. Hypertension, history of DM, and the lack of glucose control during recent hospitalization can be associated with a poor outcome.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.1007/s13410-024-01309-5</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>COVID-19 ; Diabetes ; Diabetes mellitus ; Emergency medical care ; Family Medicine ; Fasting ; General Practice ; Health Administration ; Hypertension ; Medicine ; Medicine & Public Health ; Mortality ; Mucormycosis ; Original Article ; Risk factors</subject><ispartof>International journal of diabetes in developing countries, 2024, Vol.44 (4), p.704-710</ispartof><rights>The Author(s), under exclusive licence to Research Society for Study of Diabetes in India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-1c96041a5addcfc6afc9941f34eaa33780fd5921f184c1a7e9429357f73297823</cites><orcidid>0000-0002-3752-302X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13410-024-01309-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13410-024-01309-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Salehi, Mohammadreza</creatorcontrib><creatorcontrib>Esteghamati, Alireza</creatorcontrib><creatorcontrib>Khodavaisy, Sadegh</creatorcontrib><creatorcontrib>Khajavi Rad, Nasim</creatorcontrib><creatorcontrib>Abdollahi, Alireza</creatorcontrib><creatorcontrib>Alemzadeh, Sayyed Amirsina</creatorcontrib><creatorcontrib>Nasserisina, Sadaf</creatorcontrib><creatorcontrib>Tabari, Azin</creatorcontrib><creatorcontrib>Pakdel, Farzad</creatorcontrib><creatorcontrib>Mohammadi, Saeed</creatorcontrib><creatorcontrib>Joorabloo, Neda</creatorcontrib><creatorcontrib>Abdorahimi, Mahsa</creatorcontrib><creatorcontrib>Shavandi, Mehrdad</creatorcontrib><creatorcontrib>Rabizadeh, Soghra</creatorcontrib><title>Iranian patients with diabetes and COVID-19-associated mucormycosis: Characteristics, manifestations, and mortality risk factors</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>Objective
This study evaluated the mortality risk factors in Iranian patients with diabetes mellitus (DM) and COVID-19-associated mucormycosis (CAM).
Methods
This retrospective study was conducted on confirmed CAM cases with DM. Only patients with a confirmed history of COVID-19 within the last 3 months were included. The patients were divided into the survived and deceased groups, and each group’s characteristics were studied and compared. Patients were also studied according to their DM status (known or unknown case).
Results
A total of 106 patients were included. The mortality rate was 25.5%. The most common underlying disease (hypertension, 41.5%) was significantly higher in the deceased group. Sixty-five patients (62.5%) were known cases of DM. The mean duration of DM was 12.46 years. There was a significant relationship between the DM history and mortality rate (84.6% vs. 15.4%,
p
= 0.007). The history of ICU admission was 8 times higher in unknown DM patients (
p
= 0.011, OR = 8.000, CI = 1.60–39.95). The mean HbA1C was significantly different in known DM cases (9.36 ± 2.03 vs. 8.02 ± 2.40,
p
= 0.004). The mean first day FBS, mean first BS in emergency room, and mean FBS on the first hospitalization week were 171, 202, and 167.2 mg/dL, respectively. Although mortality was significantly related to hyperglycemic state of fasting and non-fasting BS levels (
p
< 0.05), it was not related to HbA1C.
Conclusion
Patients with diabetes and COVID-19 had uncontrolled fasting and non-fasting glucose levels during mucormycosis episode. Hypertension, history of DM, and the lack of glucose control during recent hospitalization can be associated with a poor outcome.</description><subject>COVID-19</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Emergency medical care</subject><subject>Family Medicine</subject><subject>Fasting</subject><subject>General Practice</subject><subject>Health Administration</subject><subject>Hypertension</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Mucormycosis</subject><subject>Original Article</subject><subject>Risk factors</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMFuEzEQhi1EJULhBThZ4orbsWc3u-aGQksjVeoFuFqD16Yu3XXwOKpy49FxCBI3TqOR_u-b0S_EGw0XGmC4ZI2dBgWmU6ARrOqfiZW2dlQ4onkuVmAHVGgRXoiXzA8AfW_WuBK_toWWRIvcUU1hqSyfUr2XU6JvoQaWtExyc_d1-1Fpq4g5-0Q1THLe-1zmg8-c-L3c3FMhX0NJXJPnd3Ju0hi4Nmle2n7UzLlUekz1IFvsh4wNyIVfibNIjxxe_53n4sv11efNjbq9-7TdfLhV3gxQlfZ2DZ2mnqbJR7-m6K3tdMQuECEOI8Spt0ZHPXZe0xBsZyz2QxzQ2GE0eC7enry7kn_u22vuIe_L0k461MasAUH3LWVOKV8ycwnR7UqaqRycBnds2p2adq1p96dpd4TwBHELL99D-af-D_Ub1c-CWg</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Salehi, Mohammadreza</creator><creator>Esteghamati, Alireza</creator><creator>Khodavaisy, Sadegh</creator><creator>Khajavi Rad, Nasim</creator><creator>Abdollahi, Alireza</creator><creator>Alemzadeh, Sayyed Amirsina</creator><creator>Nasserisina, Sadaf</creator><creator>Tabari, Azin</creator><creator>Pakdel, Farzad</creator><creator>Mohammadi, Saeed</creator><creator>Joorabloo, Neda</creator><creator>Abdorahimi, Mahsa</creator><creator>Shavandi, Mehrdad</creator><creator>Rabizadeh, Soghra</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-3752-302X</orcidid></search><sort><creationdate>2024</creationdate><title>Iranian patients with diabetes and COVID-19-associated mucormycosis: Characteristics, manifestations, and mortality risk factors</title><author>Salehi, Mohammadreza ; Esteghamati, Alireza ; Khodavaisy, Sadegh ; Khajavi Rad, Nasim ; Abdollahi, Alireza ; Alemzadeh, Sayyed Amirsina ; Nasserisina, Sadaf ; Tabari, Azin ; Pakdel, Farzad ; Mohammadi, Saeed ; Joorabloo, Neda ; Abdorahimi, Mahsa ; Shavandi, Mehrdad ; Rabizadeh, Soghra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-1c96041a5addcfc6afc9941f34eaa33780fd5921f184c1a7e9429357f73297823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>COVID-19</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Emergency medical care</topic><topic>Family Medicine</topic><topic>Fasting</topic><topic>General Practice</topic><topic>Health Administration</topic><topic>Hypertension</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Mucormycosis</topic><topic>Original Article</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salehi, Mohammadreza</creatorcontrib><creatorcontrib>Esteghamati, Alireza</creatorcontrib><creatorcontrib>Khodavaisy, Sadegh</creatorcontrib><creatorcontrib>Khajavi Rad, Nasim</creatorcontrib><creatorcontrib>Abdollahi, Alireza</creatorcontrib><creatorcontrib>Alemzadeh, Sayyed Amirsina</creatorcontrib><creatorcontrib>Nasserisina, Sadaf</creatorcontrib><creatorcontrib>Tabari, Azin</creatorcontrib><creatorcontrib>Pakdel, Farzad</creatorcontrib><creatorcontrib>Mohammadi, Saeed</creatorcontrib><creatorcontrib>Joorabloo, Neda</creatorcontrib><creatorcontrib>Abdorahimi, Mahsa</creatorcontrib><creatorcontrib>Shavandi, Mehrdad</creatorcontrib><creatorcontrib>Rabizadeh, Soghra</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salehi, Mohammadreza</au><au>Esteghamati, Alireza</au><au>Khodavaisy, Sadegh</au><au>Khajavi Rad, Nasim</au><au>Abdollahi, Alireza</au><au>Alemzadeh, Sayyed Amirsina</au><au>Nasserisina, Sadaf</au><au>Tabari, Azin</au><au>Pakdel, Farzad</au><au>Mohammadi, Saeed</au><au>Joorabloo, Neda</au><au>Abdorahimi, Mahsa</au><au>Shavandi, Mehrdad</au><au>Rabizadeh, Soghra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iranian patients with diabetes and COVID-19-associated mucormycosis: Characteristics, manifestations, and mortality risk factors</atitle><jtitle>International journal of diabetes in developing countries</jtitle><stitle>Int J Diabetes Dev Ctries</stitle><date>2024</date><risdate>2024</risdate><volume>44</volume><issue>4</issue><spage>704</spage><epage>710</epage><pages>704-710</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>Objective
This study evaluated the mortality risk factors in Iranian patients with diabetes mellitus (DM) and COVID-19-associated mucormycosis (CAM).
Methods
This retrospective study was conducted on confirmed CAM cases with DM. Only patients with a confirmed history of COVID-19 within the last 3 months were included. The patients were divided into the survived and deceased groups, and each group’s characteristics were studied and compared. Patients were also studied according to their DM status (known or unknown case).
Results
A total of 106 patients were included. The mortality rate was 25.5%. The most common underlying disease (hypertension, 41.5%) was significantly higher in the deceased group. Sixty-five patients (62.5%) were known cases of DM. The mean duration of DM was 12.46 years. There was a significant relationship between the DM history and mortality rate (84.6% vs. 15.4%,
p
= 0.007). The history of ICU admission was 8 times higher in unknown DM patients (
p
= 0.011, OR = 8.000, CI = 1.60–39.95). The mean HbA1C was significantly different in known DM cases (9.36 ± 2.03 vs. 8.02 ± 2.40,
p
= 0.004). The mean first day FBS, mean first BS in emergency room, and mean FBS on the first hospitalization week were 171, 202, and 167.2 mg/dL, respectively. Although mortality was significantly related to hyperglycemic state of fasting and non-fasting BS levels (
p
< 0.05), it was not related to HbA1C.
Conclusion
Patients with diabetes and COVID-19 had uncontrolled fasting and non-fasting glucose levels during mucormycosis episode. Hypertension, history of DM, and the lack of glucose control during recent hospitalization can be associated with a poor outcome.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13410-024-01309-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3752-302X</orcidid></addata></record> |
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| ispartof | International journal of diabetes in developing countries, 2024, Vol.44 (4), p.704-710 |
| issn | 0973-3930 1998-3832 |
| language | eng |
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| source | Springer Journals |
| subjects | COVID-19 Diabetes Diabetes mellitus Emergency medical care Family Medicine Fasting General Practice Health Administration Hypertension Medicine Medicine & Public Health Mortality Mucormycosis Original Article Risk factors |
| title | Iranian patients with diabetes and COVID-19-associated mucormycosis: Characteristics, manifestations, and mortality risk factors |
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