Effects of LICT-BFR on cardiopulmonary fitness and immune function in youth
Cardiopulmonary fitness (CRF) is on the decline among youth. This study aimed to investigate the effects of a low-intensity serial blood flow restriction training exercise protocol on CRF and body composition indices in youth. It also aimed to reveal changes in immune status following low-intensity...
Gespeichert in:
| Veröffentlicht in: | Sport sciences for health 2024-12, Vol.20 (4), p.1235-1242 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1242 |
|---|---|
| container_issue | 4 |
| container_start_page | 1235 |
| container_title | Sport sciences for health |
| container_volume | 20 |
| creator | Qian, Haonan Shu, Wanyu Wen, Shixiong Lee, Seongno |
| description | Cardiopulmonary fitness (CRF) is on the decline among youth. This study aimed to investigate the effects of a low-intensity serial blood flow restriction training exercise protocol on CRF and body composition indices in youth. It also aimed to reveal changes in immune status following low-intensity continuous training exercise in adolescents, shedding light on the regulation of human immunity by exercise. We recruited 50 non-smoking, healthy, and non-exercising young volunteers and randomly divided them into a low-intensity continuous training group (LICT-BFR,
n
= 25) and a no-exercise Control group (
n
= 25), with the experimental intervention lasting for ten weeks. Physical function was assessed before and after the intervention. Peripheral blood leukocytes were analyzed for microRNA (miRNA) using Agilent human microRNA 2.0 and genetic software. MiRNA quantification was conducted through reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). Flow cytometry was used to measure the percentage of various lymphocytes. The results showed that maximum oxygen uptake (
V
O
2
max,
p
|
| doi_str_mv | 10.1007/s11332-024-01195-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3122401940</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3122401940</sourcerecordid><originalsourceid>FETCH-LOGICAL-c200t-76ba68b5f51b41daf8204c4c89244058bdf3a324b27913672536f7c55925a4743</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EEqXwAkyWmA3HtzgZoSpQUQkJldlynBhSNXaxk6Fvj2mQ2JjOGb7_XD6ErincUgB1lyjlnBFgggCllSTlCZrRkklCGRenx14QJSo4RxcpbQFkIWU1Qy9L51o7JBwcXq8WG_Lw-IaDx9bEpgv7cdcHb-IBu27wbUrY-AZ3fT_6FrvR26HLbOfxIYzD5yU6c2aX2qvfOkfvj8vN4pmsX59Wi_s1sQxgIKqoTVHW0klaC9oYVzIQVtiyYkKALOvGccOZqJmqKC8Uk7xwyuZzmTRCCT5HN9PcfQxfY5sGvQ1j9Hml5pQxAbQSkCk2UTaGlGLr9D52ff5FU9A_0vQkTWdp-ihNlznEp1DKsP9o49_of1LfwjttHQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3122401940</pqid></control><display><type>article</type><title>Effects of LICT-BFR on cardiopulmonary fitness and immune function in youth</title><source>SpringerLink Journals - AutoHoldings</source><creator>Qian, Haonan ; Shu, Wanyu ; Wen, Shixiong ; Lee, Seongno</creator><creatorcontrib>Qian, Haonan ; Shu, Wanyu ; Wen, Shixiong ; Lee, Seongno</creatorcontrib><description>Cardiopulmonary fitness (CRF) is on the decline among youth. This study aimed to investigate the effects of a low-intensity serial blood flow restriction training exercise protocol on CRF and body composition indices in youth. It also aimed to reveal changes in immune status following low-intensity continuous training exercise in adolescents, shedding light on the regulation of human immunity by exercise. We recruited 50 non-smoking, healthy, and non-exercising young volunteers and randomly divided them into a low-intensity continuous training group (LICT-BFR,
n
= 25) and a no-exercise Control group (
n
= 25), with the experimental intervention lasting for ten weeks. Physical function was assessed before and after the intervention. Peripheral blood leukocytes were analyzed for microRNA (miRNA) using Agilent human microRNA 2.0 and genetic software. MiRNA quantification was conducted through reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). Flow cytometry was used to measure the percentage of various lymphocytes. The results showed that maximum oxygen uptake (
V
O
2
max,
p
< 0.01) and the percentage of body fat (
p
< 0.05) were significantly higher in the exercise group compared to the Control group. The LICT-BFR group exhibited a significant decrease in fat mass and visceral fat area (
p
< 0.05) and an increase in muscle mass (
p
< 0.05) compared to the Control group. Additionally, six miRNAs (hsa-miR150-5p, 31-5p, 3659, 4419a, 650, and 8485) exhibited reduced expression, with miR-150 showing a significant decrease identified by RT-qPCR (
p
= 0.021). The percentage of CD3 + T cells was lower in the LICT-BFR group than in the non-exercising subjects (
p
< 0.001). However, the CD4 + to CD8 + ratio and the percentage of CD4 + T cells showed no significant differences between these two groups. In summary, low-intensity blood flow-restricted continuous training improved CRF in youth and resulted in a statistically significant reduction in T cell numbers and hsa-miR150-5p expression during prolonged exercise training. LICT-BFR was found to modulate the immune system by suppressing T cell and hsa-miR150-5p levels. This study supports the use of low-intensity blood flow restriction continuous training as an ideal exercise protocol.</description><identifier>ISSN: 1824-7490</identifier><identifier>EISSN: 1825-1234</identifier><identifier>DOI: 10.1007/s11332-024-01195-8</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Blood pressure ; Body fat ; Body mass index ; Bone density ; Exercise ; Fitness equipment ; Heart rate ; Human Physiology ; Intervention ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Mortality ; Muscle strength ; Performance evaluation ; Physical fitness ; Sports Medicine ; Variance analysis ; Young adults</subject><ispartof>Sport sciences for health, 2024-12, Vol.20 (4), p.1235-1242</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c200t-76ba68b5f51b41daf8204c4c89244058bdf3a324b27913672536f7c55925a4743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11332-024-01195-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11332-024-01195-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Qian, Haonan</creatorcontrib><creatorcontrib>Shu, Wanyu</creatorcontrib><creatorcontrib>Wen, Shixiong</creatorcontrib><creatorcontrib>Lee, Seongno</creatorcontrib><title>Effects of LICT-BFR on cardiopulmonary fitness and immune function in youth</title><title>Sport sciences for health</title><addtitle>Sport Sci Health</addtitle><description>Cardiopulmonary fitness (CRF) is on the decline among youth. This study aimed to investigate the effects of a low-intensity serial blood flow restriction training exercise protocol on CRF and body composition indices in youth. It also aimed to reveal changes in immune status following low-intensity continuous training exercise in adolescents, shedding light on the regulation of human immunity by exercise. We recruited 50 non-smoking, healthy, and non-exercising young volunteers and randomly divided them into a low-intensity continuous training group (LICT-BFR,
n
= 25) and a no-exercise Control group (
n
= 25), with the experimental intervention lasting for ten weeks. Physical function was assessed before and after the intervention. Peripheral blood leukocytes were analyzed for microRNA (miRNA) using Agilent human microRNA 2.0 and genetic software. MiRNA quantification was conducted through reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). Flow cytometry was used to measure the percentage of various lymphocytes. The results showed that maximum oxygen uptake (
V
O
2
max,
p
< 0.01) and the percentage of body fat (
p
< 0.05) were significantly higher in the exercise group compared to the Control group. The LICT-BFR group exhibited a significant decrease in fat mass and visceral fat area (
p
< 0.05) and an increase in muscle mass (
p
< 0.05) compared to the Control group. Additionally, six miRNAs (hsa-miR150-5p, 31-5p, 3659, 4419a, 650, and 8485) exhibited reduced expression, with miR-150 showing a significant decrease identified by RT-qPCR (
p
= 0.021). The percentage of CD3 + T cells was lower in the LICT-BFR group than in the non-exercising subjects (
p
< 0.001). However, the CD4 + to CD8 + ratio and the percentage of CD4 + T cells showed no significant differences between these two groups. In summary, low-intensity blood flow-restricted continuous training improved CRF in youth and resulted in a statistically significant reduction in T cell numbers and hsa-miR150-5p expression during prolonged exercise training. LICT-BFR was found to modulate the immune system by suppressing T cell and hsa-miR150-5p levels. This study supports the use of low-intensity blood flow restriction continuous training as an ideal exercise protocol.</description><subject>Blood pressure</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Bone density</subject><subject>Exercise</subject><subject>Fitness equipment</subject><subject>Heart rate</subject><subject>Human Physiology</subject><subject>Intervention</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Muscle strength</subject><subject>Performance evaluation</subject><subject>Physical fitness</subject><subject>Sports Medicine</subject><subject>Variance analysis</subject><subject>Young adults</subject><issn>1824-7490</issn><issn>1825-1234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOwzAUhi0EEqXwAkyWmA3HtzgZoSpQUQkJldlynBhSNXaxk6Fvj2mQ2JjOGb7_XD6ErincUgB1lyjlnBFgggCllSTlCZrRkklCGRenx14QJSo4RxcpbQFkIWU1Qy9L51o7JBwcXq8WG_Lw-IaDx9bEpgv7cdcHb-IBu27wbUrY-AZ3fT_6FrvR26HLbOfxIYzD5yU6c2aX2qvfOkfvj8vN4pmsX59Wi_s1sQxgIKqoTVHW0klaC9oYVzIQVtiyYkKALOvGccOZqJmqKC8Uk7xwyuZzmTRCCT5HN9PcfQxfY5sGvQ1j9Hml5pQxAbQSkCk2UTaGlGLr9D52ff5FU9A_0vQkTWdp-ihNlznEp1DKsP9o49_of1LfwjttHQ</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Qian, Haonan</creator><creator>Shu, Wanyu</creator><creator>Wen, Shixiong</creator><creator>Lee, Seongno</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20241201</creationdate><title>Effects of LICT-BFR on cardiopulmonary fitness and immune function in youth</title><author>Qian, Haonan ; Shu, Wanyu ; Wen, Shixiong ; Lee, Seongno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c200t-76ba68b5f51b41daf8204c4c89244058bdf3a324b27913672536f7c55925a4743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Blood pressure</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Bone density</topic><topic>Exercise</topic><topic>Fitness equipment</topic><topic>Heart rate</topic><topic>Human Physiology</topic><topic>Intervention</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Muscle strength</topic><topic>Performance evaluation</topic><topic>Physical fitness</topic><topic>Sports Medicine</topic><topic>Variance analysis</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qian, Haonan</creatorcontrib><creatorcontrib>Shu, Wanyu</creatorcontrib><creatorcontrib>Wen, Shixiong</creatorcontrib><creatorcontrib>Lee, Seongno</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Sport sciences for health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qian, Haonan</au><au>Shu, Wanyu</au><au>Wen, Shixiong</au><au>Lee, Seongno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of LICT-BFR on cardiopulmonary fitness and immune function in youth</atitle><jtitle>Sport sciences for health</jtitle><stitle>Sport Sci Health</stitle><date>2024-12-01</date><risdate>2024</risdate><volume>20</volume><issue>4</issue><spage>1235</spage><epage>1242</epage><pages>1235-1242</pages><issn>1824-7490</issn><eissn>1825-1234</eissn><abstract>Cardiopulmonary fitness (CRF) is on the decline among youth. This study aimed to investigate the effects of a low-intensity serial blood flow restriction training exercise protocol on CRF and body composition indices in youth. It also aimed to reveal changes in immune status following low-intensity continuous training exercise in adolescents, shedding light on the regulation of human immunity by exercise. We recruited 50 non-smoking, healthy, and non-exercising young volunteers and randomly divided them into a low-intensity continuous training group (LICT-BFR,
n
= 25) and a no-exercise Control group (
n
= 25), with the experimental intervention lasting for ten weeks. Physical function was assessed before and after the intervention. Peripheral blood leukocytes were analyzed for microRNA (miRNA) using Agilent human microRNA 2.0 and genetic software. MiRNA quantification was conducted through reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). Flow cytometry was used to measure the percentage of various lymphocytes. The results showed that maximum oxygen uptake (
V
O
2
max,
p
< 0.01) and the percentage of body fat (
p
< 0.05) were significantly higher in the exercise group compared to the Control group. The LICT-BFR group exhibited a significant decrease in fat mass and visceral fat area (
p
< 0.05) and an increase in muscle mass (
p
< 0.05) compared to the Control group. Additionally, six miRNAs (hsa-miR150-5p, 31-5p, 3659, 4419a, 650, and 8485) exhibited reduced expression, with miR-150 showing a significant decrease identified by RT-qPCR (
p
= 0.021). The percentage of CD3 + T cells was lower in the LICT-BFR group than in the non-exercising subjects (
p
< 0.001). However, the CD4 + to CD8 + ratio and the percentage of CD4 + T cells showed no significant differences between these two groups. In summary, low-intensity blood flow-restricted continuous training improved CRF in youth and resulted in a statistically significant reduction in T cell numbers and hsa-miR150-5p expression during prolonged exercise training. LICT-BFR was found to modulate the immune system by suppressing T cell and hsa-miR150-5p levels. This study supports the use of low-intensity blood flow restriction continuous training as an ideal exercise protocol.</abstract><cop>Milan</cop><pub>Springer Milan</pub><doi>10.1007/s11332-024-01195-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1824-7490 |
| ispartof | Sport sciences for health, 2024-12, Vol.20 (4), p.1235-1242 |
| issn | 1824-7490 1825-1234 |
| language | eng |
| recordid | cdi_proquest_journals_3122401940 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Blood pressure Body fat Body mass index Bone density Exercise Fitness equipment Heart rate Human Physiology Intervention Medicine Medicine & Public Health Metabolic Diseases Metabolism Mortality Muscle strength Performance evaluation Physical fitness Sports Medicine Variance analysis Young adults |
| title | Effects of LICT-BFR on cardiopulmonary fitness and immune function in youth |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T10%3A45%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20LICT-BFR%20on%20cardiopulmonary%20fitness%20and%20immune%20function%20in%20youth&rft.jtitle=Sport%20sciences%20for%20health&rft.au=Qian,%20Haonan&rft.date=2024-12-01&rft.volume=20&rft.issue=4&rft.spage=1235&rft.epage=1242&rft.pages=1235-1242&rft.issn=1824-7490&rft.eissn=1825-1234&rft_id=info:doi/10.1007/s11332-024-01195-8&rft_dat=%3Cproquest_cross%3E3122401940%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3122401940&rft_id=info:pmid/&rfr_iscdi=true |