Mirtazapine enhances the effect of haloperidol on apomorphine-induced climbing behaviour in mice and attenuates haloperidol-induced catalepsy in rats

Activation of 5-HT1A receptors has been shown to attenuate catalepsy induced by typical antipsychotic compounds. Since mirtazapine (Remeron; Org 3770) has indirect 5-HT1A receptor stimulating properties as well as antagonist properties at alpha2-adrenoceptors and 5-HT2 receptors, it was of interest...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Psychopharmacologia 1998-02, Vol.135 (3), p.284-289
Hauptverfasser:	BERENDSEN, H. H. G, BROEKKAMP, C. L. E, PINDER, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin Animals Antidepressive Agents, Tricyclic - pharmacology Antipsychotic Agents - pharmacology Antipsychotics Apomorphine Apomorphine - pharmacology Biological and medical sciences Catalepsy Catalepsy - chemically induced Catalepsy - psychology Climbing Dopamine Agonists - pharmacology Dose-Response Relationship, Drug Extrapyramidal system Haloperidol Haloperidol - pharmacology Male Medical sciences Mianserin - analogs & derivatives Mianserin - pharmacology Mice Mice, Inbred ICR Mirtazapine Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic drugs Rats Rats, Sprague-Dawley Receptor mechanisms
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!