Development of Two Synthetic Routes to 4‐(N‐Boc‐N‐methylaminomethyl)benzaldehyde: A Versatile Starting Material in Pharmaceutical Synthesis

Two novel synthetic routes to 4‐(N‐Boc‐N‐methylaminomethyl)benzaldehyde, an important pharmaceutical starting material, were developed using terephthaloyl chloride and terephthalaldehyde. In the first approach, terephthaloyl chloride was converted to an ester amide. The treatment of the ester amide...

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Veröffentlicht in:	Asian journal of organic chemistry 2024-10, Vol.13 (10), p.n/a
Hauptverfasser:	Park, Jinjae, Jeong, Myunghoon, Li, Shirun, Seo, Ju‐Ahn, Lee, Yong Ho, Cheon, Cheol‐Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(N-methylaminomethyl)benzaldehyde Aldehydes Benzaldehyde Benzyl alcohol Boc protecting group Chemoselective synthesis Chlorides Desymmetrization strategy Lithium aluminum hydrides Pharmaceutical starting material synthesis Pharmaceuticals Synthesis
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