The Clinical and Genetic Landscape of Hereditary Cancer: Experience from a Single Clinical Diagnostic Laboratory

The application of next-generation sequencing (NGS) technology in the genetic investigation of hereditary cancer is important for clinical surveillance, therapeutic approach, and reducing the risk of developing new malignancies. The aim of the study was to explore genetic predisposition in individua...

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Veröffentlicht in:	Cancer genomics & proteomics 2024-09, Vol.21 (5), p.448-463
Hauptverfasser:	Tsoulos, Nikolaos, Agiannitopoulos, Konstantinos, Potska, Kevisa, Katseli, Anastasia, Ntogka, Christina, Pepe, Georgia, Bouzarelou, Dimitra, Papathanasiou, Athanasios, Grigoriadis, Dimitrios, Tsaousis, Georgios N, Gogas, Helen, Troupis, Theodore, Papazisis, Konstantinos, Natsiopoulos, Ioannis, Venizelos, Vassileios, Amarantidis, Kyriakos, Giassas, Stylianos, Papadimitriou, Christos, Fountzilas, Elena, Stathoulopoulou, Maroulio, Koumarianou, Anna, Xepapadakis, Grigorios, Blidaru, Alexandru, Zob, Daniela, Voinea, Oana, Özdoğan, Mustafa, Ergören, Mahmut Çerkez, Hegmane, Alinta, Papadopoulou, Eirini, Nasioulas, George, Markopoulos, Christos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics BRCA1 protein BRCA2 protein Breast cancer Colorectal cancer Colorectal carcinoma Copy number E-cadherin Female Gene sequencing Genetic Predisposition to Disease Genetic screening Genetic testing Genetic Testing - methods Genetics High-Throughput Nucleotide Sequencing - methods Humans Laboratories, Clinical Male Malignancy Middle Aged MLH1 protein MSH2 protein MSH6 protein Neoplasms - diagnosis Neoplasms - genetics Neoplastic Syndromes, Hereditary - diagnosis Neoplastic Syndromes, Hereditary - genetics Next-generation sequencing Ovarian cancer p53 Protein Prostate cancer PTEN protein Risk reduction Whole genome sequencing Young Adult
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