Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium
Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when...
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| Veröffentlicht in: | Russian journal of general chemistry 2024-08, Vol.94 (8), p.1967-1971 |
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| container_end_page | 1971 |
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| container_issue | 8 |
| container_start_page | 1967 |
| container_title | Russian journal of general chemistry |
| container_volume | 94 |
| creator | Gatiatulin, A. K. Klimovitskii, A. E. Ziganshin, M. A. Gorbatchuk, V. V. |
| description | Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium. |
| doi_str_mv | 10.1134/S1070363224080097 |
| format | Article |
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K. ; Klimovitskii, A. E. ; Ziganshin, M. A. ; Gorbatchuk, V. V.</creator><creatorcontrib>Gatiatulin, A. K. ; Klimovitskii, A. E. ; Ziganshin, M. A. ; Gorbatchuk, V. V.</creatorcontrib><description>Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363224080097</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Cyclodextrins ; Diclofenac ; Hydration ; Infrared spectroscopy ; Sodium ; Solid state ; Thermal stability ; X ray powder diffraction</subject><ispartof>Russian journal of general chemistry, 2024-08, Vol.94 (8), p.1967-1971</ispartof><rights>Pleiades Publishing, Ltd. 2024</rights><rights>Pleiades Publishing, Ltd. 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c198t-ea2d94ca927d05ad9389130a2483a2c6f7124a02dc5dcbd454bb4052dfb953c73</cites><orcidid>0000-0002-4119-7300 ; 0000-0002-5347-2066 ; 0000-0002-8280-6774 ; 0000-0003-0513-8298</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070363224080097$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070363224080097$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Gatiatulin, A. K.</creatorcontrib><creatorcontrib>Klimovitskii, A. E.</creatorcontrib><creatorcontrib>Ziganshin, M. A.</creatorcontrib><creatorcontrib>Gorbatchuk, V. V.</creatorcontrib><title>Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Cyclodextrins</subject><subject>Diclofenac</subject><subject>Hydration</subject><subject>Infrared spectroscopy</subject><subject>Sodium</subject><subject>Solid state</subject><subject>Thermal stability</subject><subject>X ray powder diffraction</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1UE1LxDAQDaLguvoDvAU8Vycf_TpK_VpYVKgepaRJql26TU1Sdf-9KRU8iHOZmTfvvYGH0CmBc0IYvygJpMASRimHDCBP99CCJJBFjMWwH-Zwjqb7ITpybgNAABK6QC-l6VoVlV54jR-tHoQVvjU9Ng1e9bIb3bQUZjuYsVdugu8D4UPjYic7o_SXt23v8Gfr3_BVG6BG90Li0qh23B6jg0Z0Tp_89CV6vrl-Ku6i9cPtqrhcR5LkmY-0oCrnUuQ0VRALlbMsJwwE5RkTVCZNSigXQJWMlawVj3ldc4ipauo8ZjJlS3Q2-w7WvI_a-WpjRtuHlxUL8ZBQCQssMrOkNc5Z3VSDbbfC7ioC1ZRi9SfFoKGzxgVu_6rtr_P_om-cvXPs</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Gatiatulin, A. 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V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c198t-ea2d94ca927d05ad9389130a2483a2c6f7124a02dc5dcbd454bb4052dfb953c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Cyclodextrins</topic><topic>Diclofenac</topic><topic>Hydration</topic><topic>Infrared spectroscopy</topic><topic>Sodium</topic><topic>Solid state</topic><topic>Thermal stability</topic><topic>X ray powder diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gatiatulin, A. K.</creatorcontrib><creatorcontrib>Klimovitskii, A. E.</creatorcontrib><creatorcontrib>Ziganshin, M. A.</creatorcontrib><creatorcontrib>Gorbatchuk, V. V.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gatiatulin, A. K.</au><au>Klimovitskii, A. E.</au><au>Ziganshin, M. A.</au><au>Gorbatchuk, V. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2024-08-01</date><risdate>2024</risdate><volume>94</volume><issue>8</issue><spage>1967</spage><epage>1971</epage><pages>1967-1971</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>Inclusion compounds of diclofenac sodium, a non-steroidal anti-inflammatory drug, with native α-, β- and γ-cyclodextrins at varying levels of hydration were prepared by co-grinding in a ball mill. Using TG/DSC analysis, powder X-ray diffraction and solid-state IR spectroscopy, it was shown that when equimolar mixtures of native cyclodextrin and diclofenac are milled, complete inclusion of this pharmaceutical ingredient occurs, regardless of cyclodextrin hydration. The absence of water-guest competition in the solid-state inclusion process is explained by high affinity of diclofenac sodium to cyclodextrins. The prepared complexes have a significantly lower thermal stability than the separate native cyclodextrins and diclofenac sodium.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363224080097</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4119-7300</orcidid><orcidid>https://orcid.org/0000-0002-5347-2066</orcidid><orcidid>https://orcid.org/0000-0002-8280-6774</orcidid><orcidid>https://orcid.org/0000-0003-0513-8298</orcidid></addata></record> |
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| language | eng |
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| subjects | Chemistry Chemistry and Materials Science Chemistry/Food Science Cyclodextrins Diclofenac Hydration Infrared spectroscopy Sodium Solid state Thermal stability X ray powder diffraction |
| title | Solid-State Preparation of Inclusion Compounds of Native Cyclodextrins with Diclofenac Sodium |
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