Synthesis, Antibacterial, and Antibiofilm Activity of Novel Sulfonyl-1H-1,2,3-triazolo-1H-imidazole-2-sulfonamides

An efficient one-pot approach was proposed for the synthesis of novel sulfonyl-1 H -1,2,3-triazolo-1 H -imidazole-2-sulfonamides. The newly synthesized derivatives were screened for in vitro antibacterial inhibition potency against gram-positive strains. Among the tested compounds, N -({1-[(4-chloro...

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Veröffentlicht in:Russian journal of general chemistry 2024-08, Vol.94 (8), p.2189-2196
Hauptverfasser: Varaprasadu, Botla Durga, Haridasyam, Sharath Babu, Koppula, Shiva Kumar
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container_title Russian journal of general chemistry
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creator Varaprasadu, Botla Durga
Haridasyam, Sharath Babu
Koppula, Shiva Kumar
description An efficient one-pot approach was proposed for the synthesis of novel sulfonyl-1 H -1,2,3-triazolo-1 H -imidazole-2-sulfonamides. The newly synthesized derivatives were screened for in vitro antibacterial inhibition potency against gram-positive strains. Among the tested compounds, N -({1-[(4-chlorophenyl)sulfonyl]-1 H -1,2,3-triazol-4-yl}methyl)-1-methyl-1 H -imidazole-2-sulfonamide and N -({1-[(4-cyanophenyl)sulfonyl]-1 H -1,2,3-triazol-4-yl}methyl)-1-methyl-1 H -imidazole-2-sulfonamide had a minimum inhibitory concentration (MIC) of 3.12 μg/mL against B. subtilis , which is two times higher than the normal streptomycin (6.25 μg/mL). It also had a MIC value of 6.25 μg/mL against S. aureus that was the same as the positive control. Also the antibiofilm profiles for the potent compounds showed that the active derivatives were not only very good at killing bacteria, but they were also very good at stopping the growth of B. subtilis biofilm.
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subjects Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Imidazole
Streptomycin
Sulfonamides
Synthesis
title Synthesis, Antibacterial, and Antibiofilm Activity of Novel Sulfonyl-1H-1,2,3-triazolo-1H-imidazole-2-sulfonamides
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