Synthesis, Characterization, and Performance of Zirconia Nanoparticulates as an Antibacterial, Antifungal, and Anticancer Activity Agent
Over the past decade, metal oxide nanostructures have been widely explored for health-related applications due to their novel physicochemical properties along with antimicrobial and anticancer activities. Here, nanoparticles (NPs) of zirconia (ZrO 2 ) were synthesized via a co-precipitation route. D...
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| description | Over the past decade, metal oxide nanostructures have been widely explored for health-related applications due to their novel physicochemical properties along with antimicrobial and anticancer activities. Here, nanoparticles (NPs) of zirconia (ZrO
2
) were synthesized via a co-precipitation route. Different structural and chemical properties of these NPs were assessed by powder X-ray diffractometry (PXRD), dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), surface texture by Brunauer-Emmett-Teller (BET)-surface area analysis, and infrared spectroscopy. XRD profile analysis has confirmed the formation of a highly crystalline single-phase monoclinic structure. The crystallite size estimated from Debye–Scherrer’s equation was found to be ~6 nm which is in good agreement with the size estimated from the
W
-
H
plot analysis. TEM image analysis showed the quintuple-shaped particles with the size in the range of 45–50 nm. The DLS showed an average particle size of 287 ± 5 nm and had a nearly stable zeta potential value of (−25.8 ± 5.3 mV). The specific surface area, 139.2 m
2
/g, is the highest ever reported value for monoclinic structured ZrO
2
NPs. The “broth micro-dilution method” was employed to test the antimicrobial action of ZrO
2
NPs against gram-negative and gram-positive bacteria and fungi. For certain strains, NPs demonstrated comparable or much better activity performance than the standard drugs. ZrO
2
NPs were found potent against the
S. pyogenes
bacterium which may be due to oxidative stress generated on the cell wall of the membrane by Zr
4+
to Zr
3+
conversion. In vitro cytotoxicity testing of these NPs against normal fibroblast cells, Chang liver cells, and MCF-7 breast cancer cells was also examined. The effectiveness of ZrO
2
NPs against investigated cancer cells can be ordered as MCF-7 breast cancer cells > normal fibroblast cells > Chang liver cells. |
| doi_str_mv | 10.1007/s12668-024-01483-0 |
| format | Article |
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2
) were synthesized via a co-precipitation route. Different structural and chemical properties of these NPs were assessed by powder X-ray diffractometry (PXRD), dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), surface texture by Brunauer-Emmett-Teller (BET)-surface area analysis, and infrared spectroscopy. XRD profile analysis has confirmed the formation of a highly crystalline single-phase monoclinic structure. The crystallite size estimated from Debye–Scherrer’s equation was found to be ~6 nm which is in good agreement with the size estimated from the
W
-
H
plot analysis. TEM image analysis showed the quintuple-shaped particles with the size in the range of 45–50 nm. The DLS showed an average particle size of 287 ± 5 nm and had a nearly stable zeta potential value of (−25.8 ± 5.3 mV). The specific surface area, 139.2 m
2
/g, is the highest ever reported value for monoclinic structured ZrO
2
NPs. The “broth micro-dilution method” was employed to test the antimicrobial action of ZrO
2
NPs against gram-negative and gram-positive bacteria and fungi. For certain strains, NPs demonstrated comparable or much better activity performance than the standard drugs. ZrO
2
NPs were found potent against the
S. pyogenes
bacterium which may be due to oxidative stress generated on the cell wall of the membrane by Zr
4+
to Zr
3+
conversion. In vitro cytotoxicity testing of these NPs against normal fibroblast cells, Chang liver cells, and MCF-7 breast cancer cells was also examined. The effectiveness of ZrO
2
NPs against investigated cancer cells can be ordered as MCF-7 breast cancer cells > normal fibroblast cells > Chang liver cells.</description><identifier>ISSN: 2191-1630</identifier><identifier>EISSN: 2191-1649</identifier><identifier>DOI: 10.1007/s12668-024-01483-0</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anticancer properties ; Antiinfectives and antibacterials ; Antitumor activity ; Bacteria ; Biological and Medical Physics ; Biomaterials ; Biophysics ; Breast cancer ; Cell walls ; Chemical properties ; Chemical synthesis ; Circuits and Systems ; Crystallites ; Crystals ; Cytotoxicity ; Cytotoxicity testing ; Dilution ; Engineering ; Fibroblasts ; Fungicides ; Gram-negative bacteria ; Gram-positive bacteria ; Hepatocytes ; Image analysis ; Image processing ; Infrared analysis ; Infrared spectroscopy ; Light scattering ; Liver ; Liver cancer ; Metal oxides ; Monoclinic lattice ; Nanoparticles ; Nanotechnology ; Oxidative stress ; Photon correlation spectroscopy ; Physicochemical properties ; Surface area ; Surface layers ; Toxicity testing ; Transmission electron microscopy ; Zeta potential ; Zirconia ; Zirconium dioxide</subject><ispartof>BioNanoScience, 2024-09, Vol.14 (3), p.2529-2540</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c200t-f2f761e5a6e35432ab619c4d394baa9be409dc1e434197b6ab3b74a1f58899a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12668-024-01483-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12668-024-01483-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids></links><search><creatorcontrib>Modi, Shrey K.</creatorcontrib><creatorcontrib>Nehra, Monika</creatorcontrib><creatorcontrib>Kumar, Sandeep</creatorcontrib><creatorcontrib>Mange, Priya L.</creatorcontrib><creatorcontrib>Modi, Kunal B.</creatorcontrib><creatorcontrib>Dubey, Swati</creatorcontrib><title>Synthesis, Characterization, and Performance of Zirconia Nanoparticulates as an Antibacterial, Antifungal, and Anticancer Activity Agent</title><title>BioNanoScience</title><addtitle>BioNanoSci</addtitle><description>Over the past decade, metal oxide nanostructures have been widely explored for health-related applications due to their novel physicochemical properties along with antimicrobial and anticancer activities. Here, nanoparticles (NPs) of zirconia (ZrO
2
) were synthesized via a co-precipitation route. Different structural and chemical properties of these NPs were assessed by powder X-ray diffractometry (PXRD), dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), surface texture by Brunauer-Emmett-Teller (BET)-surface area analysis, and infrared spectroscopy. XRD profile analysis has confirmed the formation of a highly crystalline single-phase monoclinic structure. The crystallite size estimated from Debye–Scherrer’s equation was found to be ~6 nm which is in good agreement with the size estimated from the
W
-
H
plot analysis. TEM image analysis showed the quintuple-shaped particles with the size in the range of 45–50 nm. The DLS showed an average particle size of 287 ± 5 nm and had a nearly stable zeta potential value of (−25.8 ± 5.3 mV). The specific surface area, 139.2 m
2
/g, is the highest ever reported value for monoclinic structured ZrO
2
NPs. The “broth micro-dilution method” was employed to test the antimicrobial action of ZrO
2
NPs against gram-negative and gram-positive bacteria and fungi. For certain strains, NPs demonstrated comparable or much better activity performance than the standard drugs. ZrO
2
NPs were found potent against the
S. pyogenes
bacterium which may be due to oxidative stress generated on the cell wall of the membrane by Zr
4+
to Zr
3+
conversion. In vitro cytotoxicity testing of these NPs against normal fibroblast cells, Chang liver cells, and MCF-7 breast cancer cells was also examined. The effectiveness of ZrO
2
NPs against investigated cancer cells can be ordered as MCF-7 breast cancer cells > normal fibroblast cells > Chang liver cells.</description><subject>Anticancer properties</subject><subject>Antiinfectives and antibacterials</subject><subject>Antitumor activity</subject><subject>Bacteria</subject><subject>Biological and Medical Physics</subject><subject>Biomaterials</subject><subject>Biophysics</subject><subject>Breast cancer</subject><subject>Cell walls</subject><subject>Chemical properties</subject><subject>Chemical synthesis</subject><subject>Circuits and Systems</subject><subject>Crystallites</subject><subject>Crystals</subject><subject>Cytotoxicity</subject><subject>Cytotoxicity testing</subject><subject>Dilution</subject><subject>Engineering</subject><subject>Fibroblasts</subject><subject>Fungicides</subject><subject>Gram-negative bacteria</subject><subject>Gram-positive bacteria</subject><subject>Hepatocytes</subject><subject>Image analysis</subject><subject>Image processing</subject><subject>Infrared analysis</subject><subject>Infrared spectroscopy</subject><subject>Light scattering</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Metal oxides</subject><subject>Monoclinic lattice</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Oxidative stress</subject><subject>Photon correlation spectroscopy</subject><subject>Physicochemical properties</subject><subject>Surface area</subject><subject>Surface layers</subject><subject>Toxicity testing</subject><subject>Transmission electron microscopy</subject><subject>Zeta potential</subject><subject>Zirconia</subject><subject>Zirconium dioxide</subject><issn>2191-1630</issn><issn>2191-1649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kM9KAzEQxoMoWGpfwFPAa1eTTbq7OZbiPygqqBcvYTZN2pQ2qUlWqE_gY7vbFb05DMwMfN9v4EPonJJLSkh5FWleFFVGcp4RyiuWkSM0yKmgGS24OP7dGTlFoxjXpK2SFKxiA_T1vHdppaONYzxbQQCVdLCfkKx3YwxugZ90MD5swSmNvcFvNijvLOAHcH4HIVnVbCDpiKFth6cu2bqnwGZ8OE3jlt3e0bpbdayApyrZD5v2eLrULp2hEwObqEc_c4heb65fZnfZ_PH2fjadZyonJGUmN2VB9QQKzSac5VAXVCi-YILXAKLWnIiFopozTkVZF1CzuuRAzaSqhADGhuii5-6Cf290THLtm-Dal5JR2nZbpFXlvUoFH2PQRu6C3ULYS0pkF7rsQ5dt6PIQuuxMrDfFVuyWOvyh_3F9A7Nnhfg</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Modi, Shrey K.</creator><creator>Nehra, Monika</creator><creator>Kumar, Sandeep</creator><creator>Mange, Priya L.</creator><creator>Modi, Kunal B.</creator><creator>Dubey, Swati</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20240901</creationdate><title>Synthesis, Characterization, and Performance of Zirconia Nanoparticulates as an Antibacterial, Antifungal, and Anticancer Activity Agent</title><author>Modi, Shrey K. ; Nehra, Monika ; Kumar, Sandeep ; Mange, Priya L. ; Modi, Kunal B. ; Dubey, Swati</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c200t-f2f761e5a6e35432ab619c4d394baa9be409dc1e434197b6ab3b74a1f58899a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anticancer properties</topic><topic>Antiinfectives and antibacterials</topic><topic>Antitumor activity</topic><topic>Bacteria</topic><topic>Biological and Medical Physics</topic><topic>Biomaterials</topic><topic>Biophysics</topic><topic>Breast cancer</topic><topic>Cell walls</topic><topic>Chemical properties</topic><topic>Chemical synthesis</topic><topic>Circuits and Systems</topic><topic>Crystallites</topic><topic>Crystals</topic><topic>Cytotoxicity</topic><topic>Cytotoxicity testing</topic><topic>Dilution</topic><topic>Engineering</topic><topic>Fibroblasts</topic><topic>Fungicides</topic><topic>Gram-negative bacteria</topic><topic>Gram-positive bacteria</topic><topic>Hepatocytes</topic><topic>Image analysis</topic><topic>Image processing</topic><topic>Infrared analysis</topic><topic>Infrared spectroscopy</topic><topic>Light scattering</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Metal oxides</topic><topic>Monoclinic lattice</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Oxidative stress</topic><topic>Photon correlation spectroscopy</topic><topic>Physicochemical properties</topic><topic>Surface area</topic><topic>Surface layers</topic><topic>Toxicity testing</topic><topic>Transmission electron microscopy</topic><topic>Zeta potential</topic><topic>Zirconia</topic><topic>Zirconium dioxide</topic><toplevel>online_resources</toplevel><creatorcontrib>Modi, Shrey K.</creatorcontrib><creatorcontrib>Nehra, Monika</creatorcontrib><creatorcontrib>Kumar, Sandeep</creatorcontrib><creatorcontrib>Mange, Priya L.</creatorcontrib><creatorcontrib>Modi, Kunal B.</creatorcontrib><creatorcontrib>Dubey, Swati</creatorcontrib><collection>CrossRef</collection><jtitle>BioNanoScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Modi, Shrey K.</au><au>Nehra, Monika</au><au>Kumar, Sandeep</au><au>Mange, Priya L.</au><au>Modi, Kunal B.</au><au>Dubey, Swati</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, Characterization, and Performance of Zirconia Nanoparticulates as an Antibacterial, Antifungal, and Anticancer Activity Agent</atitle><jtitle>BioNanoScience</jtitle><stitle>BioNanoSci</stitle><date>2024-09-01</date><risdate>2024</risdate><volume>14</volume><issue>3</issue><spage>2529</spage><epage>2540</epage><pages>2529-2540</pages><issn>2191-1630</issn><eissn>2191-1649</eissn><abstract>Over the past decade, metal oxide nanostructures have been widely explored for health-related applications due to their novel physicochemical properties along with antimicrobial and anticancer activities. Here, nanoparticles (NPs) of zirconia (ZrO
2
) were synthesized via a co-precipitation route. Different structural and chemical properties of these NPs were assessed by powder X-ray diffractometry (PXRD), dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), surface texture by Brunauer-Emmett-Teller (BET)-surface area analysis, and infrared spectroscopy. XRD profile analysis has confirmed the formation of a highly crystalline single-phase monoclinic structure. The crystallite size estimated from Debye–Scherrer’s equation was found to be ~6 nm which is in good agreement with the size estimated from the
W
-
H
plot analysis. TEM image analysis showed the quintuple-shaped particles with the size in the range of 45–50 nm. The DLS showed an average particle size of 287 ± 5 nm and had a nearly stable zeta potential value of (−25.8 ± 5.3 mV). The specific surface area, 139.2 m
2
/g, is the highest ever reported value for monoclinic structured ZrO
2
NPs. The “broth micro-dilution method” was employed to test the antimicrobial action of ZrO
2
NPs against gram-negative and gram-positive bacteria and fungi. For certain strains, NPs demonstrated comparable or much better activity performance than the standard drugs. ZrO
2
NPs were found potent against the
S. pyogenes
bacterium which may be due to oxidative stress generated on the cell wall of the membrane by Zr
4+
to Zr
3+
conversion. In vitro cytotoxicity testing of these NPs against normal fibroblast cells, Chang liver cells, and MCF-7 breast cancer cells was also examined. The effectiveness of ZrO
2
NPs against investigated cancer cells can be ordered as MCF-7 breast cancer cells > normal fibroblast cells > Chang liver cells.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12668-024-01483-0</doi><tpages>12</tpages></addata></record> |
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| subjects | Anticancer properties Antiinfectives and antibacterials Antitumor activity Bacteria Biological and Medical Physics Biomaterials Biophysics Breast cancer Cell walls Chemical properties Chemical synthesis Circuits and Systems Crystallites Crystals Cytotoxicity Cytotoxicity testing Dilution Engineering Fibroblasts Fungicides Gram-negative bacteria Gram-positive bacteria Hepatocytes Image analysis Image processing Infrared analysis Infrared spectroscopy Light scattering Liver Liver cancer Metal oxides Monoclinic lattice Nanoparticles Nanotechnology Oxidative stress Photon correlation spectroscopy Physicochemical properties Surface area Surface layers Toxicity testing Transmission electron microscopy Zeta potential Zirconia Zirconium dioxide |
| title | Synthesis, Characterization, and Performance of Zirconia Nanoparticulates as an Antibacterial, Antifungal, and Anticancer Activity Agent |
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