Synthesis and Biological Activity of 2,6-Substituted Pyridoxine Derivatives. Unusual Catalytic Role of Selenium Dioxide in the Formation of Pyridinone Methides

Among the seven-membered ketals of pyridoxine containing hydroxymethyl groups in various positions of the pyridine ring, an unusual ability of selenium dioxide to catalyze the reaction of nucleophilic substitution of the hydroxyl group by N , O -nucleophiles was found. Quantum chemical calculations...

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Veröffentlicht in:	Russian journal of general chemistry 2024-08, Vol.94 (8), p.1912-1929
Hauptverfasser:	Khaziev, R. M., Platonova, E. A., Bondar, O. V., Khristolyubova, A. S., Serov, N. Y., Lisovskaya, S. A., Vafina, R. M., Shtyrlin, V. G., Shtyrlin, N. V., Islamov, D. R., Burilov, V. A., Romanova, E. I., Shtyrlin, Yu. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Biological activity Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Dioxides Hydroxyl groups Nucleophiles Pyridoxine Quantum chemistry Selenium dioxide Substitution reactions Substrates
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