Exosomal TNF-α mediates voltage-gated Na+ channel 1.6 overexpression and contributes to brain tumor–induced neuronal hyperexcitability

Patients affected by glioma frequently experience epileptic discharges; however, the causes of brain tumor-related epilepsy (BTRE) are still not completely understood. We investigated the mechanisms underlying BTRE by analyzing the effects of exosomes released by U87 glioma cells and by patient-deri...

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Veröffentlicht in:	The Journal of clinical investigation 2024-09, Vol.134 (18), p.1-17
Hauptverfasser:	Trivino, Cesar Adolfo Sanchez, Spelat, Renza, Spada, Federica, D'Angelo, Camilla, Manini, Ivana, Rolle, Irene Giulia, Ius, Tamara, Parisse, Pietro, Menini, Anna, Cesselli, Daniela, Skrap, Miran, Cesca, Fabrizia, Torre, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain cancer Brain tumors Channel gating Communication Cytokines Epilepsy Exosomes Experiments Extracellular vesicles Glioma Glioma cells Hippocampus Infliximab Membrane potential Monoclonal antibodies Motility Neurons Patients Phenotypes Rheumatoid arthritis Sodium channels (voltage-gated) Stem cells Tumor necrosis factor-TNF Tumor necrosis factor-α
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