1753-P: Alteration of Splice Type in Type 2 Ryanodine Receptor Causes Impaired Insulin Secretion in Mice

Increase of intracellular Ca2+ concentration is essential for glucose-induced insulin secretion. Type 2 ryanodine receptor (RyR2) is a Ca2+ release channel that mobilizes Ca2+ from the endoplasmic reticulum to the cytosol. Unlike RyR2 mRNA expressed in heart, RyR2 mRNA expressed in pancreatic β cell...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73, p.1
Hauptverfasser:	Makino, Mai, Uchiyama, Tomoko, Oshima, Yu, Daikoku, Takiko, Yamamoto, Yasuhiko, Okamoto, Hiroshi, Nakamura, Shuhei, Takasawa, Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Beta cells Blood levels Calcium (intracellular) Calcium (reticular) Calcium mobilization Calcium release channels CRISPR Cytosol Endoplasmic reticulum Enzyme-linked immunosorbent assay Genotypes Glucose Glucose tolerance Insulin Insulin secretion mRNA Pancreas Ryanodine receptors
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