1667-P: Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D)
Aim: To evaluate the safety and metabolic effects of mesenteric visceral lipectomy in individuals with T2D. Methods & Study Design: Eight T2D subjects (age = 52±4 y; BMI = 34.1±1.0; stable diabetes meds/weight for 3 months) underwent pre-MVL assessment including OGTT, CGM, euglycemic insulin cla...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73 (Supplement_1), p.1 |
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| creator | BASKOY, GOZDE PETERSON, RICHARD M. KEMPENICH, JASON W. TRIPLITT, CURTIS L. CLARKE, GEOFFREY D. CERSOSIMO, EUGENIO ANDREW, MARK S. MEROVCI, AURORA LAVRYNENKO, OLGA HANSIS-DIARTE, ANDREA A. SOLIS-HERRERA, CAROLINA CHAVEZ, ALBERTO SALEHI, MARZIEH DEFRONZO, RALPH A. |
| description | Aim: To evaluate the safety and metabolic effects of mesenteric visceral lipectomy in individuals with T2D.
Methods & Study Design: Eight T2D subjects (age = 52±4 y; BMI = 34.1±1.0; stable diabetes meds/weight for 3 months) underwent pre-MVL assessment including OGTT, CGM, euglycemic insulin clamp with 3H-glucose, and MRI imaging. Repeat measurements were made at 6- and 12-months post-surgery. Exclusion criteria included prior insulin/TZD use. Insulin secretion [IS], Disposition Index [DI] and Matsuda index [MI] of insulin sensitivity were calculated with standard formulae.
Results: At month 6, HbA1c decreased from 9.0% to 8.1% (p=0.08) and persisted at 8.4% at month 12 (p=0.19). CGM time-in-range increased significantly at 6 and 12 months (25% to 76%) (p |
| doi_str_mv | 10.2337/db24-1667-P |
| format | Article |
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Methods & Study Design: Eight T2D subjects (age = 52±4 y; BMI = 34.1±1.0; stable diabetes meds/weight for 3 months) underwent pre-MVL assessment including OGTT, CGM, euglycemic insulin clamp with 3H-glucose, and MRI imaging. Repeat measurements were made at 6- and 12-months post-surgery. Exclusion criteria included prior insulin/TZD use. Insulin secretion [IS], Disposition Index [DI] and Matsuda index [MI] of insulin sensitivity were calculated with standard formulae.
Results: At month 6, HbA1c decreased from 9.0% to 8.1% (p=0.08) and persisted at 8.4% at month 12 (p=0.19). CGM time-in-range increased significantly at 6 and 12 months (25% to 76%) (p<0.05). Suppression of hepatic glucose production increased at months 6 and 12 (p<0.05). Body weight and % body fat decreased slightly at month 12 (p<0.05). Insulin secretion and disposition index during OGTT increased more than 2-fold at month 6 and persisted at month 12.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db24-1667-P</identifier><language>eng</language><publisher>New York: American Diabetes Association</publisher><subject>Body fat ; Body weight ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Glucose ; Glucose tolerance ; Insulin ; Insulin secretion ; Liposuction</subject><ispartof>Diabetes (New York, N.Y.), 2024-06, Vol.73 (Supplement_1), p.1</ispartof><rights>Copyright American Diabetes Association Jun 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>BASKOY, GOZDE</creatorcontrib><creatorcontrib>PETERSON, RICHARD M.</creatorcontrib><creatorcontrib>KEMPENICH, JASON W.</creatorcontrib><creatorcontrib>TRIPLITT, CURTIS L.</creatorcontrib><creatorcontrib>CLARKE, GEOFFREY D.</creatorcontrib><creatorcontrib>CERSOSIMO, EUGENIO</creatorcontrib><creatorcontrib>ANDREW, MARK S.</creatorcontrib><creatorcontrib>MEROVCI, AURORA</creatorcontrib><creatorcontrib>LAVRYNENKO, OLGA</creatorcontrib><creatorcontrib>HANSIS-DIARTE, ANDREA A.</creatorcontrib><creatorcontrib>SOLIS-HERRERA, CAROLINA</creatorcontrib><creatorcontrib>CHAVEZ, ALBERTO</creatorcontrib><creatorcontrib>SALEHI, MARZIEH</creatorcontrib><creatorcontrib>DEFRONZO, RALPH A.</creatorcontrib><title>1667-P: Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D)</title><title>Diabetes (New York, N.Y.)</title><description>Aim: To evaluate the safety and metabolic effects of mesenteric visceral lipectomy in individuals with T2D.
Methods & Study Design: Eight T2D subjects (age = 52±4 y; BMI = 34.1±1.0; stable diabetes meds/weight for 3 months) underwent pre-MVL assessment including OGTT, CGM, euglycemic insulin clamp with 3H-glucose, and MRI imaging. Repeat measurements were made at 6- and 12-months post-surgery. Exclusion criteria included prior insulin/TZD use. Insulin secretion [IS], Disposition Index [DI] and Matsuda index [MI] of insulin sensitivity were calculated with standard formulae.
Results: At month 6, HbA1c decreased from 9.0% to 8.1% (p=0.08) and persisted at 8.4% at month 12 (p=0.19). CGM time-in-range increased significantly at 6 and 12 months (25% to 76%) (p<0.05). Suppression of hepatic glucose production increased at months 6 and 12 (p<0.05). Body weight and % body fat decreased slightly at month 12 (p<0.05). Insulin secretion and disposition index during OGTT increased more than 2-fold at month 6 and persisted at month 12.</description><subject>Body fat</subject><subject>Body weight</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Insulin</subject><subject>Insulin secretion</subject><subject>Liposuction</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNotkE1LAzEQhoMoWKsn_0DAS4usZpLdpOtNWq2FLfawFG8hm81iyn6ZbC3996ZU5jCXZ96ZeRC6B_JEGRPPZUHjCDgX0eYCjSBlacSo-LpEI0KARiBScY1uvN8RQnioEWrO9AteG2_awTir8dZ6bZyqcWZ7o4euOeLJeptN8arpXfdrPF7We915g_OuDmCrDbYt3qjBhgiPD3b4xvmxN5jihVWFGcLIJKeL6S26qlTtzd1_H6P8_S2ff0TZ53I1f80izWMWzagSQLUuKyCF4BVhmoOgiuikgkIZzWLQvChTBUlCk5iWPLyTpiWdlSWnmo3Rwzk2nPuzN36Qu27v2rBRMgCgIo45C9TjmdKu896ZSvbONsodJRB50ilPOuVJkNywP0sqZXk</recordid><startdate>20240614</startdate><enddate>20240614</enddate><creator>BASKOY, GOZDE</creator><creator>PETERSON, RICHARD M.</creator><creator>KEMPENICH, JASON W.</creator><creator>TRIPLITT, CURTIS L.</creator><creator>CLARKE, GEOFFREY D.</creator><creator>CERSOSIMO, EUGENIO</creator><creator>ANDREW, MARK S.</creator><creator>MEROVCI, AURORA</creator><creator>LAVRYNENKO, OLGA</creator><creator>HANSIS-DIARTE, ANDREA A.</creator><creator>SOLIS-HERRERA, CAROLINA</creator><creator>CHAVEZ, ALBERTO</creator><creator>SALEHI, MARZIEH</creator><creator>DEFRONZO, RALPH A.</creator><general>American Diabetes Association</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20240614</creationdate><title>1667-P: Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D)</title><author>BASKOY, GOZDE ; PETERSON, RICHARD M. ; KEMPENICH, JASON W. ; TRIPLITT, CURTIS L. ; CLARKE, GEOFFREY D. ; CERSOSIMO, EUGENIO ; ANDREW, MARK S. ; MEROVCI, AURORA ; LAVRYNENKO, OLGA ; HANSIS-DIARTE, ANDREA A. ; SOLIS-HERRERA, CAROLINA ; CHAVEZ, ALBERTO ; SALEHI, MARZIEH ; DEFRONZO, RALPH A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643-82a712ccdf10b76f03c6172a0c5f1baec341c6bd9a1552542d600699d28dd62c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Body fat</topic><topic>Body weight</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Insulin</topic><topic>Insulin secretion</topic><topic>Liposuction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BASKOY, GOZDE</creatorcontrib><creatorcontrib>PETERSON, RICHARD M.</creatorcontrib><creatorcontrib>KEMPENICH, JASON W.</creatorcontrib><creatorcontrib>TRIPLITT, CURTIS L.</creatorcontrib><creatorcontrib>CLARKE, GEOFFREY D.</creatorcontrib><creatorcontrib>CERSOSIMO, EUGENIO</creatorcontrib><creatorcontrib>ANDREW, MARK S.</creatorcontrib><creatorcontrib>MEROVCI, AURORA</creatorcontrib><creatorcontrib>LAVRYNENKO, OLGA</creatorcontrib><creatorcontrib>HANSIS-DIARTE, ANDREA A.</creatorcontrib><creatorcontrib>SOLIS-HERRERA, CAROLINA</creatorcontrib><creatorcontrib>CHAVEZ, ALBERTO</creatorcontrib><creatorcontrib>SALEHI, MARZIEH</creatorcontrib><creatorcontrib>DEFRONZO, RALPH A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BASKOY, GOZDE</au><au>PETERSON, RICHARD M.</au><au>KEMPENICH, JASON W.</au><au>TRIPLITT, CURTIS L.</au><au>CLARKE, GEOFFREY D.</au><au>CERSOSIMO, EUGENIO</au><au>ANDREW, MARK S.</au><au>MEROVCI, AURORA</au><au>LAVRYNENKO, OLGA</au><au>HANSIS-DIARTE, ANDREA A.</au><au>SOLIS-HERRERA, CAROLINA</au><au>CHAVEZ, ALBERTO</au><au>SALEHI, MARZIEH</au><au>DEFRONZO, RALPH A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1667-P: Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D)</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><date>2024-06-14</date><risdate>2024</risdate><volume>73</volume><issue>Supplement_1</issue><spage>1</spage><pages>1-</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><abstract>Aim: To evaluate the safety and metabolic effects of mesenteric visceral lipectomy in individuals with T2D.
Methods & Study Design: Eight T2D subjects (age = 52±4 y; BMI = 34.1±1.0; stable diabetes meds/weight for 3 months) underwent pre-MVL assessment including OGTT, CGM, euglycemic insulin clamp with 3H-glucose, and MRI imaging. Repeat measurements were made at 6- and 12-months post-surgery. Exclusion criteria included prior insulin/TZD use. Insulin secretion [IS], Disposition Index [DI] and Matsuda index [MI] of insulin sensitivity were calculated with standard formulae.
Results: At month 6, HbA1c decreased from 9.0% to 8.1% (p=0.08) and persisted at 8.4% at month 12 (p=0.19). CGM time-in-range increased significantly at 6 and 12 months (25% to 76%) (p<0.05). Suppression of hepatic glucose production increased at months 6 and 12 (p<0.05). Body weight and % body fat decreased slightly at month 12 (p<0.05). Insulin secretion and disposition index during OGTT increased more than 2-fold at month 6 and persisted at month 12.</abstract><cop>New York</cop><pub>American Diabetes Association</pub><doi>10.2337/db24-1667-P</doi></addata></record> |
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| subjects | Body fat Body weight Diabetes Diabetes mellitus (non-insulin dependent) Glucose Glucose tolerance Insulin Insulin secretion Liposuction |
| title | 1667-P: Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D) |
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