Genetic polymorphisms associated with preeclampsia risk in Nigerian women
Background Preeclampsia, a complex hypertensive disorder unique to pregnancy, significantly impacts maternal and fetal health worldwide, with a prevalence of 2–8%. This condition results from a complex interplay of genetic, environmental, and immunological factors. Aim and objectives This study aims...
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| Veröffentlicht in: | Egyptian Journal of Medical Human Genetics 2024-09, Vol.25 (1), p.109-6, Article 109 |
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| creator | Olaniyan, Mathew F. Akpoyovwere, Obataze J. Kanikwu, Nwamaka P. Olaniyan, Tolulope B. Adeniran, Medinat T. Muhibi, Musa A. Odegbemi, Odekunle B. |
| description | Background
Preeclampsia, a complex hypertensive disorder unique to pregnancy, significantly impacts maternal and fetal health worldwide, with a prevalence of 2–8%. This condition results from a complex interplay of genetic, environmental, and immunological factors.
Aim and objectives
This study aims to investigate the genetic predispositions to preeclampsia, focusing on specific gene polymorphisms among pregnant women at Central Hospital Auchi, Nigeria.
Materials and methods
We examined the endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), and tumor necrosis factor-alpha (TNF-α) genes in 200 pregnant women, equally divided between preeclamptic patients and normotensive controls.
Results
The eNOS G894T polymorphism was significantly associated with preeclampsia, with the T allele nearly doubling the risk. The VEGF C936T polymorphism's T allele also indicated a higher risk. The D allele in the ACE gene's insertion/deletion (I/D) polymorphism significantly increased the risk, as did the A allele in the TNF-α G308A polymorphism.
Conclusions
These findings highlight the importance of genetic factors in preeclampsia and suggest that genetic screening could improve risk stratification and early detection. Future research should integrate genetic, epigenetic, and environmental data to understand preeclampsia's multifaceted nature and develop targeted therapies. This study underscores the potential of personalized medicine in managing and reducing the risks associated with preeclampsia. |
| doi_str_mv | 10.1186/s43042-024-00585-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_proquest_journals_3110963235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A810600055</galeid><doaj_id>oai_doaj_org_article_dcdf8b6433f94ca087596b343388812a</doaj_id><sourcerecordid>A810600055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-5d475c4436fce63118cc163e97a483a4df0b17eadda5c3fa0602ab330e30d3b73</originalsourceid><addsrcrecordid>eNp9UcFu1TAQjBBIlMIPcIrEOWWddRznWFVQnlS1FzhbG3v96sdLHOxUVf8et0EUJIT24PVqZjS7U1XvBZwJodXHLBFk20ArG4BOd418UZ20MEDTSile_tG_rt7kfABQHfbypNpd8sxrsPUSjw9TTMttyFOuKedoA63s6vuw3tZLYrZHmpYcqE4hf6_DXF-HPadAc30fJ57fVq88HTO_-_WeVt8-f_p68aW5urncXZxfNRb7fm06J_vOSonKW1ZY3FsrFPLQk9RI0nkYRc_kHHUWPYGClkZEYASHY4-n1W7TdZEOZklhovRgIgXzNIhpbyiVjY5snHVej0oi-kFaAt13gxqx_LXWoqWi9WHTWlL8ccd5NYd4l-Zi3xRnMChssXtG7amIhtnHNZGdQrbmXItisJz8EXX2D1Qpx1OwcWYfyvwvQrsRbIo5J_a_lxFgHlM1W6qmpGqeUjWykHAj5QKey_2fHf-H9RO1n6LI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3110963235</pqid></control><display><type>article</type><title>Genetic polymorphisms associated with preeclampsia risk in Nigerian women</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><creator>Olaniyan, Mathew F. ; Akpoyovwere, Obataze J. ; Kanikwu, Nwamaka P. ; Olaniyan, Tolulope B. ; Adeniran, Medinat T. ; Muhibi, Musa A. ; Odegbemi, Odekunle B.</creator><creatorcontrib>Olaniyan, Mathew F. ; Akpoyovwere, Obataze J. ; Kanikwu, Nwamaka P. ; Olaniyan, Tolulope B. ; Adeniran, Medinat T. ; Muhibi, Musa A. ; Odegbemi, Odekunle B.</creatorcontrib><description>Background
Preeclampsia, a complex hypertensive disorder unique to pregnancy, significantly impacts maternal and fetal health worldwide, with a prevalence of 2–8%. This condition results from a complex interplay of genetic, environmental, and immunological factors.
Aim and objectives
This study aims to investigate the genetic predispositions to preeclampsia, focusing on specific gene polymorphisms among pregnant women at Central Hospital Auchi, Nigeria.
Materials and methods
We examined the endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), and tumor necrosis factor-alpha (TNF-α) genes in 200 pregnant women, equally divided between preeclamptic patients and normotensive controls.
Results
The eNOS G894T polymorphism was significantly associated with preeclampsia, with the T allele nearly doubling the risk. The VEGF C936T polymorphism's T allele also indicated a higher risk. The D allele in the ACE gene's insertion/deletion (I/D) polymorphism significantly increased the risk, as did the A allele in the TNF-α G308A polymorphism.
Conclusions
These findings highlight the importance of genetic factors in preeclampsia and suggest that genetic screening could improve risk stratification and early detection. Future research should integrate genetic, epigenetic, and environmental data to understand preeclampsia's multifaceted nature and develop targeted therapies. This study underscores the potential of personalized medicine in managing and reducing the risks associated with preeclampsia.</description><identifier>ISSN: 2090-2441</identifier><identifier>ISSN: 1110-8630</identifier><identifier>EISSN: 2090-2441</identifier><identifier>DOI: 10.1186/s43042-024-00585-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>ACE protein ; Air pollution ; Alleles ; Angiogenesis ; Angiotensin ; Angiotensin-converting enzyme (ACE) ; Blood pressure ; DNA methylation ; Endothelial nitric oxide synthase (eNOS) ; Endothelium ; Enzymes ; Epigenetic inheritance ; Epigenetics ; Fetuses ; Gene deletion ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic factors ; Genetic polymorphisms ; Genetic research ; Genetic screening ; Genotype & phenotype ; Hypertension ; Kinases ; Medicine ; Medicine & Public Health ; Nitric oxide ; Nitric-oxide synthase ; Outdoor air quality ; Oxidative stress ; Peptidyl-dipeptidase A ; Pharmacogenetics ; Polymorphism ; Pre-eclampsia ; Precision medicine ; Preeclampsia ; Pregnancy ; Pregnancy complications ; Pregnant women ; Standard scores ; Tumor necrosis factor ; Tumor necrosis factor-alpha (TNF-α) ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Vascular endothelial growth factor ; Vascular endothelial growth factor (VEGF) ; Womens health</subject><ispartof>Egyptian Journal of Medical Human Genetics, 2024-09, Vol.25 (1), p.109-6, Article 109</ispartof><rights>The Author(s) 2024</rights><rights>COPYRIGHT 2024 Springer</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c377t-5d475c4436fce63118cc163e97a483a4df0b17eadda5c3fa0602ab330e30d3b73</cites><orcidid>0000-0002-5429-9429</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Olaniyan, Mathew F.</creatorcontrib><creatorcontrib>Akpoyovwere, Obataze J.</creatorcontrib><creatorcontrib>Kanikwu, Nwamaka P.</creatorcontrib><creatorcontrib>Olaniyan, Tolulope B.</creatorcontrib><creatorcontrib>Adeniran, Medinat T.</creatorcontrib><creatorcontrib>Muhibi, Musa A.</creatorcontrib><creatorcontrib>Odegbemi, Odekunle B.</creatorcontrib><title>Genetic polymorphisms associated with preeclampsia risk in Nigerian women</title><title>Egyptian Journal of Medical Human Genetics</title><addtitle>Egypt J Med Hum Genet</addtitle><description>Background
Preeclampsia, a complex hypertensive disorder unique to pregnancy, significantly impacts maternal and fetal health worldwide, with a prevalence of 2–8%. This condition results from a complex interplay of genetic, environmental, and immunological factors.
Aim and objectives
This study aims to investigate the genetic predispositions to preeclampsia, focusing on specific gene polymorphisms among pregnant women at Central Hospital Auchi, Nigeria.
Materials and methods
We examined the endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), and tumor necrosis factor-alpha (TNF-α) genes in 200 pregnant women, equally divided between preeclamptic patients and normotensive controls.
Results
The eNOS G894T polymorphism was significantly associated with preeclampsia, with the T allele nearly doubling the risk. The VEGF C936T polymorphism's T allele also indicated a higher risk. The D allele in the ACE gene's insertion/deletion (I/D) polymorphism significantly increased the risk, as did the A allele in the TNF-α G308A polymorphism.
Conclusions
These findings highlight the importance of genetic factors in preeclampsia and suggest that genetic screening could improve risk stratification and early detection. Future research should integrate genetic, epigenetic, and environmental data to understand preeclampsia's multifaceted nature and develop targeted therapies. This study underscores the potential of personalized medicine in managing and reducing the risks associated with preeclampsia.</description><subject>ACE protein</subject><subject>Air pollution</subject><subject>Alleles</subject><subject>Angiogenesis</subject><subject>Angiotensin</subject><subject>Angiotensin-converting enzyme (ACE)</subject><subject>Blood pressure</subject><subject>DNA methylation</subject><subject>Endothelial nitric oxide synthase (eNOS)</subject><subject>Endothelium</subject><subject>Enzymes</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Fetuses</subject><subject>Gene deletion</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic factors</subject><subject>Genetic polymorphisms</subject><subject>Genetic research</subject><subject>Genetic screening</subject><subject>Genotype & phenotype</subject><subject>Hypertension</subject><subject>Kinases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Outdoor air quality</subject><subject>Oxidative stress</subject><subject>Peptidyl-dipeptidase A</subject><subject>Pharmacogenetics</subject><subject>Polymorphism</subject><subject>Pre-eclampsia</subject><subject>Precision medicine</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnant women</subject><subject>Standard scores</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-alpha (TNF-α)</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular endothelial growth factor (VEGF)</subject><subject>Womens health</subject><issn>2090-2441</issn><issn>1110-8630</issn><issn>2090-2441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9UcFu1TAQjBBIlMIPcIrEOWWddRznWFVQnlS1FzhbG3v96sdLHOxUVf8et0EUJIT24PVqZjS7U1XvBZwJodXHLBFk20ArG4BOd418UZ20MEDTSile_tG_rt7kfABQHfbypNpd8sxrsPUSjw9TTMttyFOuKedoA63s6vuw3tZLYrZHmpYcqE4hf6_DXF-HPadAc30fJ57fVq88HTO_-_WeVt8-f_p68aW5urncXZxfNRb7fm06J_vOSonKW1ZY3FsrFPLQk9RI0nkYRc_kHHUWPYGClkZEYASHY4-n1W7TdZEOZklhovRgIgXzNIhpbyiVjY5snHVej0oi-kFaAt13gxqx_LXWoqWi9WHTWlL8ccd5NYd4l-Zi3xRnMChssXtG7amIhtnHNZGdQrbmXItisJz8EXX2D1Qpx1OwcWYfyvwvQrsRbIo5J_a_lxFgHlM1W6qmpGqeUjWykHAj5QKey_2fHf-H9RO1n6LI</recordid><startdate>20240929</startdate><enddate>20240929</enddate><creator>Olaniyan, Mathew F.</creator><creator>Akpoyovwere, Obataze J.</creator><creator>Kanikwu, Nwamaka P.</creator><creator>Olaniyan, Tolulope B.</creator><creator>Adeniran, Medinat T.</creator><creator>Muhibi, Musa A.</creator><creator>Odegbemi, Odekunle B.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5429-9429</orcidid></search><sort><creationdate>20240929</creationdate><title>Genetic polymorphisms associated with preeclampsia risk in Nigerian women</title><author>Olaniyan, Mathew F. ; Akpoyovwere, Obataze J. ; Kanikwu, Nwamaka P. ; Olaniyan, Tolulope B. ; Adeniran, Medinat T. ; Muhibi, Musa A. ; Odegbemi, Odekunle B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-5d475c4436fce63118cc163e97a483a4df0b17eadda5c3fa0602ab330e30d3b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ACE protein</topic><topic>Air pollution</topic><topic>Alleles</topic><topic>Angiogenesis</topic><topic>Angiotensin</topic><topic>Angiotensin-converting enzyme (ACE)</topic><topic>Blood pressure</topic><topic>DNA methylation</topic><topic>Endothelial nitric oxide synthase (eNOS)</topic><topic>Endothelium</topic><topic>Enzymes</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Fetuses</topic><topic>Gene deletion</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic factors</topic><topic>Genetic polymorphisms</topic><topic>Genetic research</topic><topic>Genetic screening</topic><topic>Genotype & phenotype</topic><topic>Hypertension</topic><topic>Kinases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Outdoor air quality</topic><topic>Oxidative stress</topic><topic>Peptidyl-dipeptidase A</topic><topic>Pharmacogenetics</topic><topic>Polymorphism</topic><topic>Pre-eclampsia</topic><topic>Precision medicine</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnant women</topic><topic>Standard scores</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-alpha (TNF-α)</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular endothelial growth factor (VEGF)</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olaniyan, Mathew F.</creatorcontrib><creatorcontrib>Akpoyovwere, Obataze J.</creatorcontrib><creatorcontrib>Kanikwu, Nwamaka P.</creatorcontrib><creatorcontrib>Olaniyan, Tolulope B.</creatorcontrib><creatorcontrib>Adeniran, Medinat T.</creatorcontrib><creatorcontrib>Muhibi, Musa A.</creatorcontrib><creatorcontrib>Odegbemi, Odekunle B.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Medical Human Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olaniyan, Mathew F.</au><au>Akpoyovwere, Obataze J.</au><au>Kanikwu, Nwamaka P.</au><au>Olaniyan, Tolulope B.</au><au>Adeniran, Medinat T.</au><au>Muhibi, Musa A.</au><au>Odegbemi, Odekunle B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphisms associated with preeclampsia risk in Nigerian women</atitle><jtitle>Egyptian Journal of Medical Human Genetics</jtitle><stitle>Egypt J Med Hum Genet</stitle><date>2024-09-29</date><risdate>2024</risdate><volume>25</volume><issue>1</issue><spage>109</spage><epage>6</epage><pages>109-6</pages><artnum>109</artnum><issn>2090-2441</issn><issn>1110-8630</issn><eissn>2090-2441</eissn><abstract>Background
Preeclampsia, a complex hypertensive disorder unique to pregnancy, significantly impacts maternal and fetal health worldwide, with a prevalence of 2–8%. This condition results from a complex interplay of genetic, environmental, and immunological factors.
Aim and objectives
This study aims to investigate the genetic predispositions to preeclampsia, focusing on specific gene polymorphisms among pregnant women at Central Hospital Auchi, Nigeria.
Materials and methods
We examined the endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), and tumor necrosis factor-alpha (TNF-α) genes in 200 pregnant women, equally divided between preeclamptic patients and normotensive controls.
Results
The eNOS G894T polymorphism was significantly associated with preeclampsia, with the T allele nearly doubling the risk. The VEGF C936T polymorphism's T allele also indicated a higher risk. The D allele in the ACE gene's insertion/deletion (I/D) polymorphism significantly increased the risk, as did the A allele in the TNF-α G308A polymorphism.
Conclusions
These findings highlight the importance of genetic factors in preeclampsia and suggest that genetic screening could improve risk stratification and early detection. Future research should integrate genetic, epigenetic, and environmental data to understand preeclampsia's multifaceted nature and develop targeted therapies. This study underscores the potential of personalized medicine in managing and reducing the risks associated with preeclampsia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43042-024-00585-4</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5429-9429</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals |
| subjects | ACE protein Air pollution Alleles Angiogenesis Angiotensin Angiotensin-converting enzyme (ACE) Blood pressure DNA methylation Endothelial nitric oxide synthase (eNOS) Endothelium Enzymes Epigenetic inheritance Epigenetics Fetuses Gene deletion Gene polymorphism Genes Genetic aspects Genetic factors Genetic polymorphisms Genetic research Genetic screening Genotype & phenotype Hypertension Kinases Medicine Medicine & Public Health Nitric oxide Nitric-oxide synthase Outdoor air quality Oxidative stress Peptidyl-dipeptidase A Pharmacogenetics Polymorphism Pre-eclampsia Precision medicine Preeclampsia Pregnancy Pregnancy complications Pregnant women Standard scores Tumor necrosis factor Tumor necrosis factor-alpha (TNF-α) Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular endothelial growth factor Vascular endothelial growth factor (VEGF) Womens health |
| title | Genetic polymorphisms associated with preeclampsia risk in Nigerian women |
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