Human organoids with an autologous tissueresident immune compartment

The intimate relationship between the epithelium and immune system is crucial for maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease and cancer13. Whereas stem cell-derived organoids are powerful models of epithelial function4, they lack tissue-resident immune ce...

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Veröffentlicht in:	Nature (London) 2024-09, Vol.633 (8028), p.165-4
Hauptverfasser:	Recaldin, Timothy, Steinacher, Linda, Gjeta, Bruno, Harter, Marius F, Adam, Lukas, Kromer, Kristina, Mendes, Marisa Pimentel, Bellavista, Marina, Nikolaev, Mikhail, Lazzaroni, Giacomo, Krese, Rok, Kilik, Umut, Popovic, Doris, Stoll, Bilgenaz, Gerard, Regine, Bscheider, Michael, Bickle, Marc, Cabon, Lauriane, Camp, J Gray, Gjorevski, Nikolche
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Biological effects CD4 antigen CD8 antigen Cell culture Cell migration Cytokines Cytotoxicity Effector cells Epithelial cells Epithelium Extracellular matrix Flow cytometry Homeostasis Immune system Immunological memory Immunotherapy Inflammation Intestine Lymphatic system Lymphocytes Lymphocytes T Memory cells Organoids Perturbation Physiology Stem cells T cell receptors Target acquisition Tissues Transcriptomics Tumorigenesis
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