Small activating RNA delivery in vivo: Challenges, prospects, and lessons learned from siRNA delivery

Over the last two decades, small activating RNAs (saRNAs) have quickly moved from discovery to clinical trials. Characterized as 20 nucleotide long, double stranded RNA, saRNAs have the unique ability to increase gene transcription at the chromatin level. This therapeutic modality has great potentia...

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Veröffentlicht in:	Nano research 2024-10, Vol.17 (10), p.8990-9002
Hauptverfasser:	Pandey, Shalini, Bednarz, Patrick T., Oberli, Matthias A., Veiseh, Omid
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Aptamers Atomic/Molecular Structure and Spectra Biomedicine Biotechnology Chemistry and Materials Science Chromatin Clinical trials Condensed Matter Physics Double-stranded RNA Epigenetics Expression vectors Gene expression Gene therapy Materials Science Nanoparticles Nanotechnology Nucleotide sequence Nucleotides Proteins Review Article Ribonucleic acid RNA RNA polymerase siRNA
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