Design of Ligand-Binding Proteins with Atomic Flow Matching

Designing novel proteins that bind to small molecules is a long-standing challenge in computational biology, with applications in developing catalysts, biosensors, and more. Current computational methods rely on the assumption that the binding pose of the target molecule is known, which is not alway...

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Veröffentlicht in:	arXiv.org 2024-09
Hauptverfasser:	Liu, Junqi, Li, Shaoning, Shi, Chence, Yang, Zhi, Tang, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic structure Binding Biomolecules Biosensors Fields (mathematics) Ligands Matching Proteins Two dimensional flow
Online-Zugang:	Volltext
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