Exogenous MSC based tissue regeneration: a review of immuno-protection strategies from biomaterial scaffolds
Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function. However, the efficacy of MSC-based regeneration is frequently limited by the low survival rate and limited sur...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-09, Vol.12 (36), p.8868-8882 |
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| creator | Ju, Rongbai Gao, Xinhui Zhang, Chi Tang, Wei Tian, Weidong He, Min |
| description | Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function. However, the efficacy of MSC-based regeneration is frequently limited by the low survival rate and limited survival time of transplanted MSCs. Despite the inherent immune privileges of MSCs, such as low expression of major histocompatibility complex antigens, tolerogenic properties, local immunosuppressive microenvironment creation, and induction of immune tolerance, immune rejection remains a major obstacle to their survival and regenerative potential. Evidence suggests that immune protection strategies can enhance MSC therapeutic efficacy by prolonging their survival and maintaining their biological functions. Among various immune protection strategies, biomaterial-based scaffolds or cell encapsulation systems that mediate the interaction between transplanted MSCs and the host immune system or spatially isolate MSCs from the immune system for a specific time period have shown great promise. In this review, we provide a comprehensive overview of these biomaterial-based immune protection strategies employed for exogenous MSCs, highlighting the crucial role of modulating the immune microenvironment. Each strategy is critically examined, discussing its strengths, limitations, and potential applications in MSC-based tissue engineering. By elucidating the mechanisms behind immune rejection and exploring immune protection strategies, we aim to address the challenges faced by MSC-based tissue engineering and pave the way for enhancing the therapeutic outcomes of MSC therapies. The insights gained from this review will contribute to the development of more effective strategies to protect transplanted MSCs from immune rejection and enable their successful application in regenerative medicine.
Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function. |
| doi_str_mv | 10.1039/d4tb00778f |
| format | Article |
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Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function.</description><identifier>ISSN: 2050-750X</identifier><identifier>ISSN: 2050-7518</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d4tb00778f</identifier><identifier>PMID: 39171946</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biomaterials ; Biomedical materials ; Damage tolerance ; Effectiveness ; Humans ; Immune system ; Immunological tolerance ; Major histocompatibility complex ; Mesenchymal stem cells ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - immunology ; Microenvironments ; Recovery of function ; Regeneration (physiology) ; Regenerative Medicine ; Rejection ; Reviews ; Scaffolds ; Stem cell transplantation ; Stem cells ; Structure-function relationships ; Survival ; Tissue Engineering ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2024-09, Vol.12 (36), p.8868-8882</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c226t-e8c715bc4b945a16a9733d2f6f4bebb92d0563b7ba93e5cd1e1bd1dfecdd16593</cites><orcidid>0000-0002-0862-8885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39171946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Rongbai</creatorcontrib><creatorcontrib>Gao, Xinhui</creatorcontrib><creatorcontrib>Zhang, Chi</creatorcontrib><creatorcontrib>Tang, Wei</creatorcontrib><creatorcontrib>Tian, Weidong</creatorcontrib><creatorcontrib>He, Min</creatorcontrib><title>Exogenous MSC based tissue regeneration: a review of immuno-protection strategies from biomaterial scaffolds</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function. However, the efficacy of MSC-based regeneration is frequently limited by the low survival rate and limited survival time of transplanted MSCs. Despite the inherent immune privileges of MSCs, such as low expression of major histocompatibility complex antigens, tolerogenic properties, local immunosuppressive microenvironment creation, and induction of immune tolerance, immune rejection remains a major obstacle to their survival and regenerative potential. Evidence suggests that immune protection strategies can enhance MSC therapeutic efficacy by prolonging their survival and maintaining their biological functions. Among various immune protection strategies, biomaterial-based scaffolds or cell encapsulation systems that mediate the interaction between transplanted MSCs and the host immune system or spatially isolate MSCs from the immune system for a specific time period have shown great promise. In this review, we provide a comprehensive overview of these biomaterial-based immune protection strategies employed for exogenous MSCs, highlighting the crucial role of modulating the immune microenvironment. Each strategy is critically examined, discussing its strengths, limitations, and potential applications in MSC-based tissue engineering. By elucidating the mechanisms behind immune rejection and exploring immune protection strategies, we aim to address the challenges faced by MSC-based tissue engineering and pave the way for enhancing the therapeutic outcomes of MSC therapies. The insights gained from this review will contribute to the development of more effective strategies to protect transplanted MSCs from immune rejection and enable their successful application in regenerative medicine.
Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function.</description><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Damage tolerance</subject><subject>Effectiveness</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunological tolerance</subject><subject>Major histocompatibility complex</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal Stem Cells - immunology</subject><subject>Microenvironments</subject><subject>Recovery of function</subject><subject>Regeneration (physiology)</subject><subject>Regenerative Medicine</subject><subject>Rejection</subject><subject>Reviews</subject><subject>Scaffolds</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Structure-function relationships</subject><subject>Survival</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds - chemistry</subject><issn>2050-750X</issn><issn>2050-7518</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtP3DAUhS1UVBCw6Z7KUjcVUsCOYyfujg5PCcSCQWIX-XGNPEriqZ3w-PcYZjqV6o19fT4d3XsPQt8oOaaEyRNbjZqQum7cFtotCSdFzWnzZfMmjzvoIKUFyaehomHVV7TDJK2prMQu6s5fwxMMYUr49n6GtUpg8ehTmgBHyApENfow_MIq188eXnBw2Pf9NIRiGcMI5kPGacwcPHlI2MXQY-1Dnz-iVx1ORjkXOpv20bZTXYKD9b2HHi7O57Or4ubu8np2elOYshRjAY2pKdem0rLiigola8Zs6YSrNGgtS0u4YLrWSjLgxlKg2lLrwFhLBZdsD_1c-eYG_0yQxrb3yUDXqQHypC0jkouG1E2Z0R__oYswxSF31zJKREUZ5SRTRyvKxJBSBNcuo-9VfGspaT9iaM-q-e_PGC4y_H1tOeke7Ab9u_QMHK6AmMxG_Zcjewfw_44S</recordid><startdate>20240918</startdate><enddate>20240918</enddate><creator>Ju, Rongbai</creator><creator>Gao, Xinhui</creator><creator>Zhang, Chi</creator><creator>Tang, Wei</creator><creator>Tian, Weidong</creator><creator>He, Min</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0862-8885</orcidid></search><sort><creationdate>20240918</creationdate><title>Exogenous MSC based tissue regeneration: a review of immuno-protection strategies from biomaterial scaffolds</title><author>Ju, Rongbai ; Gao, Xinhui ; Zhang, Chi ; Tang, Wei ; Tian, Weidong ; He, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-e8c715bc4b945a16a9733d2f6f4bebb92d0563b7ba93e5cd1e1bd1dfecdd16593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Damage tolerance</topic><topic>Effectiveness</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunological tolerance</topic><topic>Major histocompatibility complex</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Mesenchymal Stem Cells - immunology</topic><topic>Microenvironments</topic><topic>Recovery of function</topic><topic>Regeneration (physiology)</topic><topic>Regenerative Medicine</topic><topic>Rejection</topic><topic>Reviews</topic><topic>Scaffolds</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Structure-function relationships</topic><topic>Survival</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ju, Rongbai</creatorcontrib><creatorcontrib>Gao, Xinhui</creatorcontrib><creatorcontrib>Zhang, Chi</creatorcontrib><creatorcontrib>Tang, Wei</creatorcontrib><creatorcontrib>Tian, Weidong</creatorcontrib><creatorcontrib>He, Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Rongbai</au><au>Gao, Xinhui</au><au>Zhang, Chi</au><au>Tang, Wei</au><au>Tian, Weidong</au><au>He, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exogenous MSC based tissue regeneration: a review of immuno-protection strategies from biomaterial scaffolds</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2024-09-18</date><risdate>2024</risdate><volume>12</volume><issue>36</issue><spage>8868</spage><epage>8882</epage><pages>8868-8882</pages><issn>2050-750X</issn><issn>2050-7518</issn><eissn>2050-7518</eissn><abstract>Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function. However, the efficacy of MSC-based regeneration is frequently limited by the low survival rate and limited survival time of transplanted MSCs. Despite the inherent immune privileges of MSCs, such as low expression of major histocompatibility complex antigens, tolerogenic properties, local immunosuppressive microenvironment creation, and induction of immune tolerance, immune rejection remains a major obstacle to their survival and regenerative potential. Evidence suggests that immune protection strategies can enhance MSC therapeutic efficacy by prolonging their survival and maintaining their biological functions. Among various immune protection strategies, biomaterial-based scaffolds or cell encapsulation systems that mediate the interaction between transplanted MSCs and the host immune system or spatially isolate MSCs from the immune system for a specific time period have shown great promise. In this review, we provide a comprehensive overview of these biomaterial-based immune protection strategies employed for exogenous MSCs, highlighting the crucial role of modulating the immune microenvironment. Each strategy is critically examined, discussing its strengths, limitations, and potential applications in MSC-based tissue engineering. By elucidating the mechanisms behind immune rejection and exploring immune protection strategies, we aim to address the challenges faced by MSC-based tissue engineering and pave the way for enhancing the therapeutic outcomes of MSC therapies. The insights gained from this review will contribute to the development of more effective strategies to protect transplanted MSCs from immune rejection and enable their successful application in regenerative medicine.
Mesenchymal stem cell (MSC)-based tissue engineering holds great potential for regenerative medicine as a means of replacing damaged or lost tissues to restore their structure and function.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>39171946</pmid><doi>10.1039/d4tb00778f</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-0862-8885</orcidid></addata></record> |
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| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2024-09, Vol.12 (36), p.8868-8882 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomaterials Biomedical materials Damage tolerance Effectiveness Humans Immune system Immunological tolerance Major histocompatibility complex Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - immunology Microenvironments Recovery of function Regeneration (physiology) Regenerative Medicine Rejection Reviews Scaffolds Stem cell transplantation Stem cells Structure-function relationships Survival Tissue Engineering Tissue Scaffolds - chemistry |
| title | Exogenous MSC based tissue regeneration: a review of immuno-protection strategies from biomaterial scaffolds |
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