Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish
Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in teleosts. In this study, -/- zebrafish ( ) exhibited excessiv...
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| creator | Jia, Jing-Yi Chen, Guang-Hui Shu, Ting-Ting Lou, Qi-Yong Jin, Xia He, Jiang-Yan Xiao, Wu-Han Zhai, Gang Yin, Zhan |
| description | Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in teleosts. In this study,
-/- zebrafish (
) exhibited excessive visceral adipose tissue (VAT), lipid content, and up-regulated expression and activity of hepatic
lipogenesis (DNL) enzymes. The assay for transposase accessible chromatin with sequencing (ATAC-seq) results demonstrated that chromatin accessibility of DNL genes was increased in
-/- fish compared to
+/+ male fish, including stearoyl-CoA desaturase (
) and fatty acid synthase (
). Androgen response element (ARE) motifs in the androgen signaling pathway were significantly enriched in
+/+ male fish but not in
-/- fish. Both androgen receptor (
)-/- and wild-type (WT) zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue, lipid content, and up-regulated expression and activity of hepatic
lipogenesis enzymes. The Ar agonist BMS-564929 reduced the content of VAT and lipid content, and down-regulated acetyl-CoA carboxylase a (
),
, and
expression. Mechanistically, the rescue effect of testosterone on
-/- fish in terms of phenotypes was abolished when
was additionally depleted. Collectively, these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish, thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts. |
| doi_str_mv | 10.24272/j.issn.2095-8137.2023.324 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_3104150945</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2958297426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-e0aba345ab0ab3cc9fc324aa0d2296d2877d0829c6d14c1e87f188414c22f78e3</originalsourceid><addsrcrecordid>eNpdUU1PGzEUtCoQQYG_gFZw4ZLUn1kvlwohoJUicYELF8vr9SYv2tjBbxOJ_vp6IY1oTx75zYzevCHkktEpl7zk31dTQAxTTis10UyUGXExFVx-I6eHz6MveETOEaGmKmPK2eyEjISWWimqTsnrbWhSXPhQICyC7SAsCghLqKHHovFFiLtYdLAZKB4Biz4Wtuv8DmzvhwE0mbaJCD3EkKXFb18n2wIuz8hxazv05_t3TF4e7p_vfk7mT4-_7m7nEycq3U88tbUVUtk6A-Fc1bocxlracF7NGq7LsqGaV27WMOmY12XLtJYZc96W2osx-fHpu9nWa984H_pkO7NJsLbp3UQL5t9JgKVZxJ1hjLKSapUdrvcOKb5tPfZmDeh819ng4xYNr1ReoJR8lqlX_1FXcZvy4dAIRiVTtJKD4c0ny6WImHx72IZR81GjWZmhRjO0ZIaWzFCjycmz-OJrnoP0b2niD9HonJY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3104150945</pqid></control><display><type>article</type><title>Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Jia, Jing-Yi ; Chen, Guang-Hui ; Shu, Ting-Ting ; Lou, Qi-Yong ; Jin, Xia ; He, Jiang-Yan ; Xiao, Wu-Han ; Zhai, Gang ; Yin, Zhan</creator><creatorcontrib>Jia, Jing-Yi ; Chen, Guang-Hui ; Shu, Ting-Ting ; Lou, Qi-Yong ; Jin, Xia ; He, Jiang-Yan ; Xiao, Wu-Han ; Zhai, Gang ; Yin, Zhan ; 中国三峡集团公司中华鲟研究所三峡工程鱼类资源保护湖北省重点实验室, 湖北 宜昌 443100, 中国 ; 华中农业大学水产学院, 湖北 武汉 430070, 中国 ; 华中农业大学湖北洪山实验室, 湖北 武汉 430070, 中国 ; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China ; 中国科学院水生生物研究所淡水生态与生物技术国家重点实验室, 湖北 武汉 430072, 中国 ; 中国科学院大学现代农业科学学院, 北京 100049, 中国 ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China ; Hubei Hongshan Laboratory, Huazhong Agriculture University, Wuhan, Hubei 430070, China ; Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100049, China ; College of Fisheries, Huazhong Agriculture University, Wuhan, Hubei 430070, China ; 中国科学院种子创新研究院, 北京 100049, 中国 ; Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Chinese Sturgeon Research Institute, China Three Gorges Corporation, Yichang, Hubei 443100, China</creatorcontrib><description>Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in teleosts. In this study,
-/- zebrafish (
) exhibited excessive visceral adipose tissue (VAT), lipid content, and up-regulated expression and activity of hepatic
lipogenesis (DNL) enzymes. The assay for transposase accessible chromatin with sequencing (ATAC-seq) results demonstrated that chromatin accessibility of DNL genes was increased in
-/- fish compared to
+/+ male fish, including stearoyl-CoA desaturase (
) and fatty acid synthase (
). Androgen response element (ARE) motifs in the androgen signaling pathway were significantly enriched in
+/+ male fish but not in
-/- fish. Both androgen receptor (
)-/- and wild-type (WT) zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue, lipid content, and up-regulated expression and activity of hepatic
lipogenesis enzymes. The Ar agonist BMS-564929 reduced the content of VAT and lipid content, and down-regulated acetyl-CoA carboxylase a (
),
, and
expression. Mechanistically, the rescue effect of testosterone on
-/- fish in terms of phenotypes was abolished when
was additionally depleted. Collectively, these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish, thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.</description><identifier>ISSN: 2095-8137</identifier><identifier>ISSN: 0254-5853</identifier><identifier>EISSN: 2095-8137</identifier><identifier>DOI: 10.24272/j.issn.2095-8137.2023.324</identifier><identifier>PMID: 38485505</identifier><language>eng</language><publisher>China: Kunming Institute of Zoology, The Chinese Academy of Sciences</publisher><subject>Accessibility ; Acetyl-CoA carboxylase ; Adipose tissue ; Amino acids ; Androgen receptors ; Androgens ; Androgens - pharmacology ; Animals ; Body fat ; Chromatin ; Danio rerio ; Dehydrogenases ; Deposition ; Desaturase ; Enzymes ; Fat metabolism ; Fatty acids ; Fatty-acid synthase ; Females ; Fish ; Flutamide ; Freshwater fishes ; Genes ; Laboratory animals ; Lipid metabolism ; Lipids ; Lipogenesis ; Lipogenesis - genetics ; Liver ; Male ; Males ; Metabolism ; Obesity ; Phenotypes ; Signal Transduction ; Sod ; Stearoyl-CoA desaturase ; Testosterone ; Transposase ; Zebrafish ; Zebrafish - genetics</subject><ispartof>Dōngwùxué yánjiū, 2024-03, Vol.45 (2), p.355-366</ispartof><rights>Copyright Kunming Institute of Zoology, The Chinese Academy of Sciences Mar 2024</rights><rights>Copyright © 2024 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences. 2024 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,887,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38485505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Jing-Yi</creatorcontrib><creatorcontrib>Chen, Guang-Hui</creatorcontrib><creatorcontrib>Shu, Ting-Ting</creatorcontrib><creatorcontrib>Lou, Qi-Yong</creatorcontrib><creatorcontrib>Jin, Xia</creatorcontrib><creatorcontrib>He, Jiang-Yan</creatorcontrib><creatorcontrib>Xiao, Wu-Han</creatorcontrib><creatorcontrib>Zhai, Gang</creatorcontrib><creatorcontrib>Yin, Zhan</creatorcontrib><creatorcontrib>中国三峡集团公司中华鲟研究所三峡工程鱼类资源保护湖北省重点实验室, 湖北 宜昌 443100, 中国</creatorcontrib><creatorcontrib>华中农业大学水产学院, 湖北 武汉 430070, 中国</creatorcontrib><creatorcontrib>华中农业大学湖北洪山实验室, 湖北 武汉 430070, 中国</creatorcontrib><creatorcontrib>College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China</creatorcontrib><creatorcontrib>中国科学院水生生物研究所淡水生态与生物技术国家重点实验室, 湖北 武汉 430072, 中国</creatorcontrib><creatorcontrib>中国科学院大学现代农业科学学院, 北京 100049, 中国</creatorcontrib><creatorcontrib>State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China</creatorcontrib><creatorcontrib>Hubei Hongshan Laboratory, Huazhong Agriculture University, Wuhan, Hubei 430070, China</creatorcontrib><creatorcontrib>Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100049, China</creatorcontrib><creatorcontrib>College of Fisheries, Huazhong Agriculture University, Wuhan, Hubei 430070, China</creatorcontrib><creatorcontrib>中国科学院种子创新研究院, 北京 100049, 中国</creatorcontrib><creatorcontrib>Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Chinese Sturgeon Research Institute, China Three Gorges Corporation, Yichang, Hubei 443100, China</creatorcontrib><title>Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish</title><title>Dōngwùxué yánjiū</title><addtitle>Zool Res</addtitle><description>Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in teleosts. In this study,
-/- zebrafish (
) exhibited excessive visceral adipose tissue (VAT), lipid content, and up-regulated expression and activity of hepatic
lipogenesis (DNL) enzymes. The assay for transposase accessible chromatin with sequencing (ATAC-seq) results demonstrated that chromatin accessibility of DNL genes was increased in
-/- fish compared to
+/+ male fish, including stearoyl-CoA desaturase (
) and fatty acid synthase (
). Androgen response element (ARE) motifs in the androgen signaling pathway were significantly enriched in
+/+ male fish but not in
-/- fish. Both androgen receptor (
)-/- and wild-type (WT) zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue, lipid content, and up-regulated expression and activity of hepatic
lipogenesis enzymes. The Ar agonist BMS-564929 reduced the content of VAT and lipid content, and down-regulated acetyl-CoA carboxylase a (
),
, and
expression. Mechanistically, the rescue effect of testosterone on
-/- fish in terms of phenotypes was abolished when
was additionally depleted. Collectively, these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish, thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.</description><subject>Accessibility</subject><subject>Acetyl-CoA carboxylase</subject><subject>Adipose tissue</subject><subject>Amino acids</subject><subject>Androgen receptors</subject><subject>Androgens</subject><subject>Androgens - pharmacology</subject><subject>Animals</subject><subject>Body fat</subject><subject>Chromatin</subject><subject>Danio rerio</subject><subject>Dehydrogenases</subject><subject>Deposition</subject><subject>Desaturase</subject><subject>Enzymes</subject><subject>Fat metabolism</subject><subject>Fatty acids</subject><subject>Fatty-acid synthase</subject><subject>Females</subject><subject>Fish</subject><subject>Flutamide</subject><subject>Freshwater fishes</subject><subject>Genes</subject><subject>Laboratory animals</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Lipogenesis</subject><subject>Lipogenesis - genetics</subject><subject>Liver</subject><subject>Male</subject><subject>Males</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Phenotypes</subject><subject>Signal Transduction</subject><subject>Sod</subject><subject>Stearoyl-CoA desaturase</subject><subject>Testosterone</subject><subject>Transposase</subject><subject>Zebrafish</subject><subject>Zebrafish - 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signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish</title><author>Jia, Jing-Yi ; Chen, Guang-Hui ; Shu, Ting-Ting ; Lou, Qi-Yong ; Jin, Xia ; He, Jiang-Yan ; Xiao, Wu-Han ; Zhai, Gang ; Yin, Zhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-e0aba345ab0ab3cc9fc324aa0d2296d2877d0829c6d14c1e87f188414c22f78e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Accessibility</topic><topic>Acetyl-CoA carboxylase</topic><topic>Adipose tissue</topic><topic>Amino acids</topic><topic>Androgen receptors</topic><topic>Androgens</topic><topic>Androgens - pharmacology</topic><topic>Animals</topic><topic>Body fat</topic><topic>Chromatin</topic><topic>Danio rerio</topic><topic>Dehydrogenases</topic><topic>Deposition</topic><topic>Desaturase</topic><topic>Enzymes</topic><topic>Fat metabolism</topic><topic>Fatty acids</topic><topic>Fatty-acid synthase</topic><topic>Females</topic><topic>Fish</topic><topic>Flutamide</topic><topic>Freshwater fishes</topic><topic>Genes</topic><topic>Laboratory animals</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Lipogenesis</topic><topic>Lipogenesis - genetics</topic><topic>Liver</topic><topic>Male</topic><topic>Males</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Phenotypes</topic><topic>Signal Transduction</topic><topic>Sod</topic><topic>Stearoyl-CoA desaturase</topic><topic>Testosterone</topic><topic>Transposase</topic><topic>Zebrafish</topic><topic>Zebrafish - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Jing-Yi</creatorcontrib><creatorcontrib>Chen, Guang-Hui</creatorcontrib><creatorcontrib>Shu, Ting-Ting</creatorcontrib><creatorcontrib>Lou, Qi-Yong</creatorcontrib><creatorcontrib>Jin, Xia</creatorcontrib><creatorcontrib>He, Jiang-Yan</creatorcontrib><creatorcontrib>Xiao, Wu-Han</creatorcontrib><creatorcontrib>Zhai, Gang</creatorcontrib><creatorcontrib>Yin, Zhan</creatorcontrib><creatorcontrib>中国三峡集团公司中华鲟研究所三峡工程鱼类资源保护湖北省重点实验室, 湖北 宜昌 443100, 中国</creatorcontrib><creatorcontrib>华中农业大学水产学院, 湖北 武汉 430070, 中国</creatorcontrib><creatorcontrib>华中农业大学湖北洪山实验室, 湖北 武汉 430070, 中国</creatorcontrib><creatorcontrib>College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China</creatorcontrib><creatorcontrib>中国科学院水生生物研究所淡水生态与生物技术国家重点实验室, 湖北 武汉 430072, 中国</creatorcontrib><creatorcontrib>中国科学院大学现代农业科学学院, 北京 100049, 中国</creatorcontrib><creatorcontrib>State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China</creatorcontrib><creatorcontrib>Hubei Hongshan Laboratory, Huazhong Agriculture University, Wuhan, Hubei 430070, China</creatorcontrib><creatorcontrib>Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100049, China</creatorcontrib><creatorcontrib>College of Fisheries, Huazhong Agriculture University, Wuhan, Hubei 430070, China</creatorcontrib><creatorcontrib>中国科学院种子创新研究院, 北京 100049, 中国</creatorcontrib><creatorcontrib>Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Chinese Sturgeon Research Institute, China Three Gorges Corporation, Yichang, Hubei 443100, China</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium 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titles)</collection><jtitle>Dōngwùxué yánjiū</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Jing-Yi</au><au>Chen, Guang-Hui</au><au>Shu, Ting-Ting</au><au>Lou, Qi-Yong</au><au>Jin, Xia</au><au>He, Jiang-Yan</au><au>Xiao, Wu-Han</au><au>Zhai, Gang</au><au>Yin, Zhan</au><aucorp>中国三峡集团公司中华鲟研究所三峡工程鱼类资源保护湖北省重点实验室, 湖北 宜昌 443100, 中国</aucorp><aucorp>华中农业大学水产学院, 湖北 武汉 430070, 中国</aucorp><aucorp>华中农业大学湖北洪山实验室, 湖北 武汉 430070, 中国</aucorp><aucorp>College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China</aucorp><aucorp>中国科学院水生生物研究所淡水生态与生物技术国家重点实验室, 湖北 武汉 430072, 中国</aucorp><aucorp>中国科学院大学现代农业科学学院, 北京 100049, 中国</aucorp><aucorp>State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China</aucorp><aucorp>Hubei Hongshan Laboratory, Huazhong Agriculture University, Wuhan, Hubei 430070, China</aucorp><aucorp>Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100049, China</aucorp><aucorp>College of Fisheries, Huazhong Agriculture University, Wuhan, Hubei 430070, China</aucorp><aucorp>中国科学院种子创新研究院, 北京 100049, 中国</aucorp><aucorp>Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Chinese Sturgeon Research Institute, China Three Gorges Corporation, Yichang, Hubei 443100, China</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish</atitle><jtitle>Dōngwùxué yánjiū</jtitle><addtitle>Zool Res</addtitle><date>2024-03-18</date><risdate>2024</risdate><volume>45</volume><issue>2</issue><spage>355</spage><epage>366</epage><pages>355-366</pages><issn>2095-8137</issn><issn>0254-5853</issn><eissn>2095-8137</eissn><abstract>Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in teleosts. In this study,
-/- zebrafish (
) exhibited excessive visceral adipose tissue (VAT), lipid content, and up-regulated expression and activity of hepatic
lipogenesis (DNL) enzymes. The assay for transposase accessible chromatin with sequencing (ATAC-seq) results demonstrated that chromatin accessibility of DNL genes was increased in
-/- fish compared to
+/+ male fish, including stearoyl-CoA desaturase (
) and fatty acid synthase (
). Androgen response element (ARE) motifs in the androgen signaling pathway were significantly enriched in
+/+ male fish but not in
-/- fish. Both androgen receptor (
)-/- and wild-type (WT) zebrafish administered with Ar antagonist flutamide displayed excessive visceral adipose tissue, lipid content, and up-regulated expression and activity of hepatic
lipogenesis enzymes. The Ar agonist BMS-564929 reduced the content of VAT and lipid content, and down-regulated acetyl-CoA carboxylase a (
),
, and
expression. Mechanistically, the rescue effect of testosterone on
-/- fish in terms of phenotypes was abolished when
was additionally depleted. Collectively, these findings reveal that testosterone inhibits lipid deposition by down-regulating DNL genes via Ar in zebrafish, thus expanding our understanding of the relationship between testosterone and lipid metabolism in teleosts.</abstract><cop>China</cop><pub>Kunming Institute of Zoology, The Chinese Academy of Sciences</pub><pmid>38485505</pmid><doi>10.24272/j.issn.2095-8137.2023.324</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-8137 |
| ispartof | Dōngwùxué yánjiū, 2024-03, Vol.45 (2), p.355-366 |
| issn | 2095-8137 0254-5853 2095-8137 |
| language | eng |
| recordid | cdi_proquest_journals_3104150945 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Accessibility Acetyl-CoA carboxylase Adipose tissue Amino acids Androgen receptors Androgens Androgens - pharmacology Animals Body fat Chromatin Danio rerio Dehydrogenases Deposition Desaturase Enzymes Fat metabolism Fatty acids Fatty-acid synthase Females Fish Flutamide Freshwater fishes Genes Laboratory animals Lipid metabolism Lipids Lipogenesis Lipogenesis - genetics Liver Male Males Metabolism Obesity Phenotypes Signal Transduction Sod Stearoyl-CoA desaturase Testosterone Transposase Zebrafish Zebrafish - genetics |
| title | Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish |
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