Mediatory Effect of Inflammatory Markers (IL-1β and PAI-1) on Association of Dietary Total Antioxidant Capacity and Body Composition in Overweight and Obese Women: A Cross-Sectional Study
Background. Obesity is considered a state of chronic low-grade inflammation. Different components of the diet, like antioxidants, can have anti-inflammatory effects or cause chronic inflammation. This study investigated the dietary TAC and inflammatory markers and body composition in obese and overw...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2022-05, Vol.2022, p.1-12 |
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| container_title | International journal of clinical practice (Esher) |
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| creator | Radkhah, Parisa Mirzababaei, Atieh Shiraseb, Farideh Hosseininasab, Dorsa Clark, Cain C. T. Mirzaei, Khadijeh |
| description | Background. Obesity is considered a state of chronic low-grade inflammation. Different components of the diet, like antioxidants, can have anti-inflammatory effects or cause chronic inflammation. This study investigated the dietary TAC and inflammatory markers and body composition in obese and overweight women. Methods. This cross-sectional study was conducted on 259 women with overweight and obesity. Dietary intake was assessed by using an FFQ with 147 items, and DTAC was used to evaluate the antioxidant capacity of the diet. The anthropometric measurements, body composition, and biochemical assessments were measured by standard protocols. Results. We observed a significant positive association between DTAC and consumption of fruits (P = 0.021), vegetable oils (P |
| doi_str_mv | 10.1155/2022/2514850 |
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T. ; Mirzaei, Khadijeh</creator><contributor>Xie, Zhongqiu ; Zhongqiu Xie</contributor><creatorcontrib>Radkhah, Parisa ; Mirzababaei, Atieh ; Shiraseb, Farideh ; Hosseininasab, Dorsa ; Clark, Cain C. T. ; Mirzaei, Khadijeh ; Xie, Zhongqiu ; Zhongqiu Xie</creatorcontrib><description>Background. Obesity is considered a state of chronic low-grade inflammation. Different components of the diet, like antioxidants, can have anti-inflammatory effects or cause chronic inflammation. This study investigated the dietary TAC and inflammatory markers and body composition in obese and overweight women. Methods. This cross-sectional study was conducted on 259 women with overweight and obesity. Dietary intake was assessed by using an FFQ with 147 items, and DTAC was used to evaluate the antioxidant capacity of the diet. The anthropometric measurements, body composition, and biochemical assessments were measured by standard protocols. Results. We observed a significant positive association between DTAC and consumption of fruits (P = 0.021), vegetable oils (P < 0.001), potassium (P = 0.006), manganese (P = 0.003), and caffeine (P < 0.001), after adjusting confounders. After adjusting for age, energy intake, and physical activity, there was a significant correlation between DTAC and fat-free mass (FFM) (P:0.054), fat-free mass index (FFMI) (P:0.012), waist circumference (WC) (P:0.002), and visceral fat level (VFL) (P:0.063). FFM, FFMI, waist circumference (WC), and visceral fat area (VFA) were mediated by IL-1β. FFM, VFL, VFA, and WC were mediated by PAI-1. Conclusion. Some anthropometric indices were associated with DTAC, mediated by augmenting serum levels of IL-1β and PAI-1. Intake of foods rich in antioxidants could represent a protective strategy against chronic diseases, such as cardiovascular disease.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1155/2022/2514850</identifier><language>eng</language><publisher>London: Hindawi</publisher><subject>Antioxidants ; Blood pressure ; Body composition ; Body fat ; Body mass index ; Body measurements ; Body weight ; Caffeine ; Cardiovascular diseases ; Cross-sectional studies ; Diet ; Dietary intake ; Energy intake ; Exercise ; Fat-free body mass ; Food intake ; High density lipoprotein ; IL-1β ; Inflammation ; Manganese ; Nutrient deficiency ; Obesity ; Overweight ; Phenols ; Physical activity ; Questionnaires ; Serum levels ; Weight control ; Womens health</subject><ispartof>International journal of clinical practice (Esher), 2022-05, Vol.2022, p.1-12</ispartof><rights>Copyright © 2022 Parisa Radkhah et al.</rights><rights>Copyright © 2022 Parisa Radkhah et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c224t-85889e9c2e990a167810f6fd0d9d695a1a5769fb31464cbc5fec39fb0eb7ece83</cites><orcidid>0000-0002-6610-4617 ; 0000-0003-3631-7723 ; 0000-0003-1614-137X ; 0000-0003-0231-0478 ; 0000-0001-9279-5063 ; 0000-0002-1785-0322</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,877,27924,27925</link.rule.ids></links><search><contributor>Xie, Zhongqiu</contributor><contributor>Zhongqiu Xie</contributor><creatorcontrib>Radkhah, Parisa</creatorcontrib><creatorcontrib>Mirzababaei, Atieh</creatorcontrib><creatorcontrib>Shiraseb, Farideh</creatorcontrib><creatorcontrib>Hosseininasab, Dorsa</creatorcontrib><creatorcontrib>Clark, Cain C. T.</creatorcontrib><creatorcontrib>Mirzaei, Khadijeh</creatorcontrib><title>Mediatory Effect of Inflammatory Markers (IL-1β and PAI-1) on Association of Dietary Total Antioxidant Capacity and Body Composition in Overweight and Obese Women: A Cross-Sectional Study</title><title>International journal of clinical practice (Esher)</title><description>Background. Obesity is considered a state of chronic low-grade inflammation. Different components of the diet, like antioxidants, can have anti-inflammatory effects or cause chronic inflammation. This study investigated the dietary TAC and inflammatory markers and body composition in obese and overweight women. Methods. This cross-sectional study was conducted on 259 women with overweight and obesity. Dietary intake was assessed by using an FFQ with 147 items, and DTAC was used to evaluate the antioxidant capacity of the diet. The anthropometric measurements, body composition, and biochemical assessments were measured by standard protocols. Results. We observed a significant positive association between DTAC and consumption of fruits (P = 0.021), vegetable oils (P < 0.001), potassium (P = 0.006), manganese (P = 0.003), and caffeine (P < 0.001), after adjusting confounders. After adjusting for age, energy intake, and physical activity, there was a significant correlation between DTAC and fat-free mass (FFM) (P:0.054), fat-free mass index (FFMI) (P:0.012), waist circumference (WC) (P:0.002), and visceral fat level (VFL) (P:0.063). FFM, FFMI, waist circumference (WC), and visceral fat area (VFA) were mediated by IL-1β. FFM, VFL, VFA, and WC were mediated by PAI-1. Conclusion. Some anthropometric indices were associated with DTAC, mediated by augmenting serum levels of IL-1β and PAI-1. Intake of foods rich in antioxidants could represent a protective strategy against chronic diseases, such as cardiovascular disease.</description><subject>Antioxidants</subject><subject>Blood pressure</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Body measurements</subject><subject>Body weight</subject><subject>Caffeine</subject><subject>Cardiovascular diseases</subject><subject>Cross-sectional studies</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Energy intake</subject><subject>Exercise</subject><subject>Fat-free body mass</subject><subject>Food intake</subject><subject>High density lipoprotein</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Manganese</subject><subject>Nutrient deficiency</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Phenols</subject><subject>Physical activity</subject><subject>Questionnaires</subject><subject>Serum levels</subject><subject>Weight control</subject><subject>Womens health</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNp9kc1OGzEUhUdVkUgpOx7AUjcgOsXXM57MsBumKUQKChJUXY4c-7oxZMbBdkrzWl3zDDxTnZ81K19ffefo6J4kOQH6DYDzC0YZu2Ac8pLTD8kAhjlLgeXwMc5ZUaacZnCYfPL-kVLGeUkHyestKiOCdWsy0hplIFaTca8Xout261vhntB5cjqepPD2j4hekbt6nMIZsT2pvbcyGpg4R-V3g0FE0YMNYkHqPu7_GiX6QBqxFNKE9VZ_ZdWaNLZbWm-2UtOT6R90L2h-z8MWmc7QI_llO-wvSU0aZ71P72PAiEfr-7BS68_JgRYLj8f79yj5-WP00Nykk-n1uKknqWQsD2nJy7LCSjKsKiqgGJZAdaEVVZUqKi5A8GFR6VkGeZHLmeTxDln8U5wNUWKZHSVfdr5LZ59X6EP7aFcuxvBtBjTjwFnFI_V1R8lNVoe6XTrTxWu0QNtNP-2mn3bfT8TPd_jc9Eq8mPfp_7VUkUs</recordid><startdate>20220523</startdate><enddate>20220523</enddate><creator>Radkhah, Parisa</creator><creator>Mirzababaei, Atieh</creator><creator>Shiraseb, Farideh</creator><creator>Hosseininasab, Dorsa</creator><creator>Clark, Cain C. T.</creator><creator>Mirzaei, Khadijeh</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-6610-4617</orcidid><orcidid>https://orcid.org/0000-0003-3631-7723</orcidid><orcidid>https://orcid.org/0000-0003-1614-137X</orcidid><orcidid>https://orcid.org/0000-0003-0231-0478</orcidid><orcidid>https://orcid.org/0000-0001-9279-5063</orcidid><orcidid>https://orcid.org/0000-0002-1785-0322</orcidid></search><sort><creationdate>20220523</creationdate><title>Mediatory Effect of Inflammatory Markers (IL-1β and PAI-1) on Association of Dietary Total Antioxidant Capacity and Body Composition in Overweight and Obese Women: A Cross-Sectional Study</title><author>Radkhah, Parisa ; Mirzababaei, Atieh ; Shiraseb, Farideh ; Hosseininasab, Dorsa ; Clark, Cain C. T. ; Mirzaei, Khadijeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c224t-85889e9c2e990a167810f6fd0d9d695a1a5769fb31464cbc5fec39fb0eb7ece83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants</topic><topic>Blood pressure</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Body measurements</topic><topic>Body weight</topic><topic>Caffeine</topic><topic>Cardiovascular diseases</topic><topic>Cross-sectional studies</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Energy intake</topic><topic>Exercise</topic><topic>Fat-free body mass</topic><topic>Food intake</topic><topic>High density lipoprotein</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Manganese</topic><topic>Nutrient deficiency</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Phenols</topic><topic>Physical activity</topic><topic>Questionnaires</topic><topic>Serum levels</topic><topic>Weight control</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radkhah, Parisa</creatorcontrib><creatorcontrib>Mirzababaei, Atieh</creatorcontrib><creatorcontrib>Shiraseb, Farideh</creatorcontrib><creatorcontrib>Hosseininasab, Dorsa</creatorcontrib><creatorcontrib>Clark, Cain C. T.</creatorcontrib><creatorcontrib>Mirzaei, Khadijeh</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radkhah, Parisa</au><au>Mirzababaei, Atieh</au><au>Shiraseb, Farideh</au><au>Hosseininasab, Dorsa</au><au>Clark, Cain C. T.</au><au>Mirzaei, Khadijeh</au><au>Xie, Zhongqiu</au><au>Zhongqiu Xie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediatory Effect of Inflammatory Markers (IL-1β and PAI-1) on Association of Dietary Total Antioxidant Capacity and Body Composition in Overweight and Obese Women: A Cross-Sectional Study</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><date>2022-05-23</date><risdate>2022</risdate><volume>2022</volume><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Background. Obesity is considered a state of chronic low-grade inflammation. Different components of the diet, like antioxidants, can have anti-inflammatory effects or cause chronic inflammation. This study investigated the dietary TAC and inflammatory markers and body composition in obese and overweight women. Methods. This cross-sectional study was conducted on 259 women with overweight and obesity. Dietary intake was assessed by using an FFQ with 147 items, and DTAC was used to evaluate the antioxidant capacity of the diet. The anthropometric measurements, body composition, and biochemical assessments were measured by standard protocols. Results. We observed a significant positive association between DTAC and consumption of fruits (P = 0.021), vegetable oils (P < 0.001), potassium (P = 0.006), manganese (P = 0.003), and caffeine (P < 0.001), after adjusting confounders. After adjusting for age, energy intake, and physical activity, there was a significant correlation between DTAC and fat-free mass (FFM) (P:0.054), fat-free mass index (FFMI) (P:0.012), waist circumference (WC) (P:0.002), and visceral fat level (VFL) (P:0.063). FFM, FFMI, waist circumference (WC), and visceral fat area (VFA) were mediated by IL-1β. FFM, VFL, VFA, and WC were mediated by PAI-1. Conclusion. Some anthropometric indices were associated with DTAC, mediated by augmenting serum levels of IL-1β and PAI-1. Intake of foods rich in antioxidants could represent a protective strategy against chronic diseases, such as cardiovascular disease.</abstract><cop>London</cop><pub>Hindawi</pub><doi>10.1155/2022/2514850</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6610-4617</orcidid><orcidid>https://orcid.org/0000-0003-3631-7723</orcidid><orcidid>https://orcid.org/0000-0003-1614-137X</orcidid><orcidid>https://orcid.org/0000-0003-0231-0478</orcidid><orcidid>https://orcid.org/0000-0001-9279-5063</orcidid><orcidid>https://orcid.org/0000-0002-1785-0322</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Blood pressure Body composition Body fat Body mass index Body measurements Body weight Caffeine Cardiovascular diseases Cross-sectional studies Diet Dietary intake Energy intake Exercise Fat-free body mass Food intake High density lipoprotein IL-1β Inflammation Manganese Nutrient deficiency Obesity Overweight Phenols Physical activity Questionnaires Serum levels Weight control Womens health |
| title | Mediatory Effect of Inflammatory Markers (IL-1β and PAI-1) on Association of Dietary Total Antioxidant Capacity and Body Composition in Overweight and Obese Women: A Cross-Sectional Study |
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