12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCα/ERK/NF-κB-dependent MMP-9 expression

An increase in MMP‐9 gene expression and enzyme activity with stimulating the migration of GBM8401 glioma cells via wound healing assay by 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) was detected in glioblastoma cells GBM8401. TPA‐induced translocation of protein kinase C (PKC)α from the cytosol to m...

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Veröffentlicht in:	Journal of cellular physiology 2010-11, Vol.225 (2), p.472-481
Hauptverfasser:	Lin, Cheng-Wei, Shen, Shing-Chuan, Chien, Chih-Chiang, Yang, Liang-Yo, Shia, Lin-Ting, Chen, Yen-Chou
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Cell activation Cell migration Cytosol Enzymatic activity Enzyme activity Enzymes Extracellular signal-regulated kinase Flavonoids Gene expression Glioblastoma Glioblastoma cells Glioma Glioma cells Kaempferol Kinases Nuclear transport Phosphorylation Protein kinase C Protein transport Proteins siRNA Transfection Translocation Wound healing
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