Dysfunction of infiltrating cytotoxic CD8+ T cells within the graft promotes murine kidney allotransplant tolerance

Tolerance of mouse kidney allografts arises in grafts that develop regulatory tertiary lymphoid organs (rTLOs). Singlecell RNA-seq (scRNA-seq) data and adoptive transfer of alloreactive T cells after transplantation showed that cytotoxic CD8+ T cells are reprogrammed within the accepted graft to an...

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Veröffentlicht in:	The Journal of clinical investigation 2024-08, Vol.134 (16), p.1-18
Hauptverfasser:	Yokose, Takahiro, Szuter, Edward S, Rosales, Ivy, Guinn, Michael T, Liss, Andrew S, Baba, Taisuke, Ruddy, David A, Piquet, Michelle, Azzi, Jamil, Cosimi, A Benedict, Russell, Paul S, Madsen, Joren C, Colvin, Robert B, Alessandrini, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Allografts CD8 antigen Cytotoxicity Dendritic cells Flow cytometry Gene expression Genotype & phenotype Graft rejection Immunological tolerance Kidney transplantation Kidneys Lymphocytes Lymphocytes T Phenotypes Proteins Spleen Tumors Xenografts
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