2010-LB: Glycemic Responses to Metformin Montherapy by SNP Clusters in Patients with Type 2 Diabetes

Introduction and Objective: Glycemic responses to metformin based on 8 SNP clusters in diabetes individuals, published by Suzuki (Nature, 2024), are unknown. Employing dataset from part of Taiwan Precision Medicine Initiative (TPMI), we explored the glycemic responses to metformin by quintile SNP cluster scores. Methods: Tracking EMR from a medical center in Taiwan, we analyzed changes of fasting glucose and HbA1c, based on SNP clusters, in newly diagnosed type 2 diabetes who received metformin monotherapy for 6 months. (Fig. 1). GEE was used to compare the glycemic responses in those with Q1 vs. Q5 in each or two SNP clusters. Results: Significant reduction of fasting glucose (FG) (p=0.007) and HbA1c (p