2034-LB: Drug Screening Identifies Dicoumarol as a Novel IRE1α Inhibitor That Protects Mice from ER Stress-Induced Liver Damage

Excessive nutrition intake leads to endoplasmic reticulum (ER) stress and activate unfolded protein response (UPR) in the liver. Depending on the level and duration of ER stress, IRE1α, the most conserved branch of UPR, a dual-functional ER transmembrane protein promotes either adaptation or apoptos...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73 (Supplement_1), p.1
Hauptverfasser:	YANG, JIFENG, WEN, SHIYI, CHEN, YANMING, SHI, GUOJUN
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Diabetes mellitus (non-insulin dependent) Drug screening Endoplasmic reticulum Flow cytometry Homeostasis Kinases Liver mRNA turnover Oligomerization Phosphorylation Protein folding Ribonuclease Tunicamycin
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