1783-LB: Acute Hyperglycemia Induces Human Podocyte Apoptosis by Increasing Monocyte Release of TNF-α through ER Stress/ROS Activation of ADAM17/iRhom2 Expression

Introduction: Targeting glycemic control based on hemoglobin A1c (A1c) reduces but does not abolish the onset and progression of chronic kidney disease (CKD), suggesting factors other than A1c contribute to the residual risk. Acute hyperglycemia is associated with the development of microalbuminuria...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73 (Supplement_1), p.1
Hauptverfasser:	MEI ZHANG, RONG, OH, JISU, KUTZ, GRETA A., DUSSO, ADRIANA S., BERNAL-MIZRACHI, CARLOS
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Caspase-3 Cell activation Cell differentiation Diabetes mellitus Glucose Hemoglobin Hyperglycemia Inflammation Kidney diseases Macrophages Monocytes Phenotypes Secretome Tumor necrosis factor-α
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