1867-LB: A Real-World Study Assessing the Efficacy and Safety of Switching from Basal–Bolus Insulin Therapy to Once-Daily iGlarLixi in People with Type 2 Diabetes-Soli De-escalation

Introduction and Objective: Basal bolus insulin (BBI) therapy is associated with body weight (BW) gain and an increased risk of hypoglycemia, further increasing the treatment burden for people with T2D. This real-world study assessed the efficacy and safety of switching from BBI to iGlarLixi, a once-daily fixed-ratio combination of insulin glargine 100 U/mL plus lixisenatide, in people with T2D. Methods: This real-world retrospective study included people with T2D (≥18 years) who received ≥1 iGlarLixi prescription during the identification (ID) period following prior treatment with BBI using the Optum Market Clarity® electronic medical record dataset of people with T2D from the United States. The primary endpoint was HbA1c change at 6 months. Secondary endpoints were HbA1c change at 3 months, BW change and hypoglycemic event rate at 6 months. Results: In total, 11,887 people received ≥1 iGlarLixi prescription during the ID period, and of these, 372 had switched from a BBI regimen to iGlarLixi (mean age, 59 years; mean baseline HbA1c, 9.55%; mean baseline BW, 101.9 kg). From baseline to Month 6, switching to iGlarLixi resulted in a significant mean HbA1c reduction of −0.93% (95% confidence interval [CI]: −1.13, −0.74; p