162-OR: Sustained TNF-a Transcription Triggered in Obesity through H3K9/K18 Acetylation Is Associated with Metabolic Impairments

Obesity-induced metabolic inflammation contributes to the development of various metabolic disorders and can be induced by the consumption of high-fat diets (HFD) rich in saturated fatty acids. The role of the TNF-α in metabolic dysfunction is now clear, although the pathways that promote and sustai...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73, p.1
Hauptverfasser:	Ahmad, Rasheed, Bahman, Fatemah, Kochumon, Shihab P, Jacob, Texy K, Alrashed, Fatema, Wilson, Ajit, Arefanian, Hossein, Thomas, Reeby S, Akhter, Nadeem, Al-Mansour, Nourah, Albeloushi, Shaima, Al Madhoun, Ashraf, Sindhu, Sardar Tak, Alzaid, Fawaz, Almulla, Fahd
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adipose tissue Animal models Body fat Body weight gain Chromatin remodeling Epigenetics Fatty liver Gene regulation High fat diet Histone H3 Histones Immunoprecipitation Insulin resistance Liver Metabolic disorders Metabolism Obesity Palmitic acid Steatosis Transcription Tumor necrosis factor-α
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