344-OR: The MOTS-c/CK2 Pathway Is a Novel Molecular Target for Type 2 Diabetes in East Asians

Introduction & Objective: MOTS-c is a mitochondrial DNA-encoded microprotein that improves impaired glucose metabolism caused by aging and high fat diet. The presence of a naturally occurring genetic variant of MOTS-c, K14Q MOTS-c, increases the susceptibility to type 2 diabetes (T2D) in East As...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73 (Supplement_1), p.1
Hauptverfasser:	KUMAGAI, HIROSHI, JEONG KIM, SU, MILLER, BRENDAN, HYUNG LEE, SHIN, ZEMPO, HIROFUMI, NATSUME, TOSHIHARU, WAN, JUNXIANG, RAMIREZ, RICARDO, MEHTA, HEMAL H., NISHIDA, YUICHIRO, FUKU, NORIYUKI, DOBASHI, SHOHEI, MIYAMOTO-MIKAMI, ERI, NAITO, HISASHI, HARA, MEGUMI, IWASAKA, CHIHARU, YAMADA, YOSUKE, HIGAKI, YASUKI, TANAKA, KEITARO, YEN, KELVIN, COHEN, PINCHAS
Format:	Artikel
Sprache:	eng
Schlagworte:	Casein kinase II Diabetes Diabetes mellitus (non-insulin dependent) Fat metabolism Genetic diversity Glucose Glucose metabolism High fat diet Kinases Mitochondrial DNA Musculoskeletal system Physical activity Protein kinase C Skeletal muscle Surface plasmon resonance Therapeutic targets
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