299-OR: Discovery of Long-Acting Unimolecular Peptide Tetra-agonists Targeting GLP-1, GIP, Amylin, and Calcitonin Receptors for Enhanced Metabolic Benefits in Animal Models of Obesity

Objective: The burgeoning prevalence of obesity and associated co-morbidities necessitates innovative approaches for safe and efficacious therapies. We describe the characterization of PTT-A, a novel long-acting peptide agonist for GLP-1, GIP, Amylin and Calcitonin Receptors, in rodent models and as...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2024-06, Vol.73 (Supplement_1), p.1
Hauptverfasser:	GHOSH, SOUMITRA, VALDECANTOS, PILAR, RADA, PATRICIA, VALVERDE, ANGELA M., RONDINONE, CRISTINA M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Alanine transaminase Amylin Animal models Blood levels Body fat Body weight loss Calcitonin receptors Calcium (blood) Cell lines Chronic effects Food intake Glucose Insulin Liver diseases Metabolic disorders Metabolism Obesity Peptides Triglycerides Weight control
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