496-P: Early-Onset Diabetes Increase the Risk of Referable and Sight-Threatening Diabetic Retinopathy

Objective: This study aimed to investigate the influence of early-onset type 2 diabetes on the risk of developing diabetic retinopathy (DR), referable diabetic retinopathy (referable DR), and sight-threatening diabetic retinopathy (STDR). Method: A total of 6847 individuals with type 2 diabetes were included. Individuals diagnosed with type 2 diabetes at or before the age of 40 are defined as having early-onset T2DM. Logistic regression and interaction analysis were used to assess the risk of DR, referable DR, and STDR in early versus late-onset diabetes. Kaplan-Meier analysis and cox regression analysis were employed to measure the relationship between incidences of retinopathy and early-onset diabetes in 1507 patients without DR at baseline. Results: The early-onset group exhibited a higher prevalence of any DR, referable DR, and STDR with a diabetic duration exceeding 5 years (all P