Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents

Myxoid Liposarcomas (MLS), characterized by the expression of FUS‐CHOP fusion gene are clinically very sensitive to the DNA binding antitumor agent, trabectedin. However, resistance eventually occurs, preventing disease eradication. To investigate the mechanisms of resistance, a trabectedin resistan...

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Veröffentlicht in:	International journal of cancer 2012-07, Vol.131 (1), p.59-69
Hauptverfasser:	Uboldi, S., Bernasconi, S., Romano, M., Marchini, S., Fuso Nerini, I., Damia, G., Ganzinelli, M., Marangon, E., Sala, F., Clivio, L., Chiorino, G., Giandomenico, S. Di, Rocchi, M., Capozzi, O., Margison, G.P., Watson, A.J., Caccuri, A.M., Pastore, A., Fossati, A., Mantovani, R., Grosso, F., Tercero, J.C., Erba, E., D'Incalci, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Alkylating - pharmacology Antitumor agents Apoptosis Biological and medical sciences C-Reactive Protein - genetics Cancer CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-beta - genetics Cell fusion Cell Line, Tumor Cell lines Cellular stress response Chromatin Collateral Complementation Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Deoxyribonucleic acid Dermatology Dioxoles - pharmacology Disease resistance DNA DNA Methylation DNA methyltransferase DNA Modification Methylases - deficiency DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA Repair DNA Repair Enzymes - deficiency DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Drug Resistance, Neoplasm Fibronectins - genetics FUS gene FUS-CHOP Fusion protein Gene fusion Genes Humans Immunoprecipitation Liposarcoma, Myxoid - drug therapy Liposarcoma, Myxoid - genetics Liposarcoma, Myxoid - metabolism Liposarcoma, Myxoid - pathology Medical research Medical sciences Methylguanine Mutation myxoid liposarcoma Nucleotide excision repair O6-methylguanine-DNA methyltransferase Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Promoter Regions, Genetic Promoters resistance RNA-Binding Protein FUS - genetics RNA-Binding Protein FUS - metabolism Serum Amyloid P-Component - genetics Signal Transduction Temozolomide Tetrahydroisoquinolines - pharmacology trabectedin Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Tumors of the skin and soft tissue. Premalignant lesions Ultraviolet Rays
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