Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID‐19 patients
[LANGUAGE= "English"] INTRODUCTION: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive...
Gespeichert in:
| Veröffentlicht in: | International journal of medical biochemistry 2021-01, Vol.4 (3), p.143 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 143 |
| container_title | International journal of medical biochemistry |
| container_volume | 4 |
| creator | Alisik, Murat Erdogan, Utku Gorkem Ates, Merve Mehmet Alp Sert Ozgur Mehmet Yis Guler Bugdayci |
| description | [LANGUAGE= "English"] INTRODUCTION: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), ferritin level, and CRP-to-albumin ratio (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) and non-COVID-19 patients and to compare these parameters between subgroups according to disease severity. In addition, these parameters were evaluated for predictive value related to the severity of COVID‐19.METHODS: The data of adult patients admitted with a suspected COVID-19 infection confirmed with real-time polymerase chain reaction testing of nasal and pharyngeal swab specimens were included in this retrospective study. Outpatient COVID-19-positive patients were enrolled in the mild group, hospitalized patients were classified in the moderate group, and patients admitted to the intensive care unit were categorized in the severe group.RESULTS: A total of 1213 COVID-19-positive patients and 1034 COVID-19-negative patients were included in the study. The IGLR, NLR, PLR, CRP, CAR, and ferritin levels were significantly higher, and the leukocyte, IG, neutrophil, lymphocyte, monocyte, basophil, and eosinophil levels were significantly lower in the COVID-19-positive group than the COVID-19-negative group (p |
| doi_str_mv | 10.14744/ijmb.2021.03164 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_3095346182</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3095346182</sourcerecordid><originalsourceid>FETCH-LOGICAL-p98t-58e03b7a614eb1b5e77b6788eccb8aca5427632cf900579fd627c9a58ae937d03</originalsourceid><addsrcrecordid>eNotkM1KAzEcxIMoWGrvHgOet-Y72aPUr0KhHop4K9nsfzVld1OTbKHgwUfwGX0SV_Q0c_jNDAxCl5TMqdBCXPtdV80ZYXROOFXiBE2YoqZQgr2cjl4aXTCu2DmapeQrIsYQZVRM0MdThNq77A-AD7YdAIcG-66zeYiAX6Pthza4YwbswtBnbPsah_wGEfu-ae0vGOIR7220HWSICTch4tonsAlwggNEn48jjBfr5-Xt9-cXLUc6e-hzukBnjW0TzP51ijb3d5vFY7FaPywXN6tiX5pcSAOEV9oqKqCilQStK6WNAecqY52VgmnFmWtKQqQum1ox7UorjYWS65rwKbr6q93H8D5AyttdGGI_Lm45KSUX41WM_wAZBmRI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095346182</pqid></control><display><type>article</type><title>Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID‐19 patients</title><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><creator>Alisik, Murat ; Erdogan, Utku Gorkem ; Ates, Merve ; Mehmet Alp Sert ; Ozgur Mehmet Yis ; Guler Bugdayci</creator><creatorcontrib>Alisik, Murat ; Erdogan, Utku Gorkem ; Ates, Merve ; Mehmet Alp Sert ; Ozgur Mehmet Yis ; Guler Bugdayci</creatorcontrib><description>[LANGUAGE= "English"] INTRODUCTION: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), ferritin level, and CRP-to-albumin ratio (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) and non-COVID-19 patients and to compare these parameters between subgroups according to disease severity. In addition, these parameters were evaluated for predictive value related to the severity of COVID‐19.METHODS: The data of adult patients admitted with a suspected COVID-19 infection confirmed with real-time polymerase chain reaction testing of nasal and pharyngeal swab specimens were included in this retrospective study. Outpatient COVID-19-positive patients were enrolled in the mild group, hospitalized patients were classified in the moderate group, and patients admitted to the intensive care unit were categorized in the severe group.RESULTS: A total of 1213 COVID-19-positive patients and 1034 COVID-19-negative patients were included in the study. The IGLR, NLR, PLR, CRP, CAR, and ferritin levels were significantly higher, and the leukocyte, IG, neutrophil, lymphocyte, monocyte, basophil, and eosinophil levels were significantly lower in the COVID-19-positive group than the COVID-19-negative group (p<0.05 for all). The severe group had higher median IG, IGLR, neutrophil, NLR, PLR levels than the mild, moderate, and COVID-19-negative groups (p<0.05 for all). Receiver operating characteristic analysis revealed an area under the curve value for IGLR, CAR, CRP, IG, NLR, and ferritin of 0.868, 0.860, 0.834, 0.848, 0.845, 0.841, and 0.827, respectively, which differentiated severe COVID-19 patients from mild and moderate COVID-19 patients.DISCUSSION AND CONCLUSION: The results suggest that the IGLR may be useful to distinguish severe COVID-19 patients at the time of admission. Further exploration is warranted to fully determine the potential value of the IGLR in disease monitoring.</description><identifier>ISSN: 2587-2362</identifier><identifier>EISSN: 2618-642X</identifier><identifier>DOI: 10.14744/ijmb.2021.03164</identifier><language>eng</language><publisher>Istanbul: Kare Publishing</publisher><subject>Blood tests ; Coronaviruses ; COVID-19 ; Granulocytes ; Intensive care ; Leukocytes ; Lymphocytes ; Neutrophils ; Polymerase chain reaction</subject><ispartof>International journal of medical biochemistry, 2021-01, Vol.4 (3), p.143</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Alisik, Murat</creatorcontrib><creatorcontrib>Erdogan, Utku Gorkem</creatorcontrib><creatorcontrib>Ates, Merve</creatorcontrib><creatorcontrib>Mehmet Alp Sert</creatorcontrib><creatorcontrib>Ozgur Mehmet Yis</creatorcontrib><creatorcontrib>Guler Bugdayci</creatorcontrib><title>Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID‐19 patients</title><title>International journal of medical biochemistry</title><description>[LANGUAGE= "English"] INTRODUCTION: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), ferritin level, and CRP-to-albumin ratio (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) and non-COVID-19 patients and to compare these parameters between subgroups according to disease severity. In addition, these parameters were evaluated for predictive value related to the severity of COVID‐19.METHODS: The data of adult patients admitted with a suspected COVID-19 infection confirmed with real-time polymerase chain reaction testing of nasal and pharyngeal swab specimens were included in this retrospective study. Outpatient COVID-19-positive patients were enrolled in the mild group, hospitalized patients were classified in the moderate group, and patients admitted to the intensive care unit were categorized in the severe group.RESULTS: A total of 1213 COVID-19-positive patients and 1034 COVID-19-negative patients were included in the study. The IGLR, NLR, PLR, CRP, CAR, and ferritin levels were significantly higher, and the leukocyte, IG, neutrophil, lymphocyte, monocyte, basophil, and eosinophil levels were significantly lower in the COVID-19-positive group than the COVID-19-negative group (p<0.05 for all). The severe group had higher median IG, IGLR, neutrophil, NLR, PLR levels than the mild, moderate, and COVID-19-negative groups (p<0.05 for all). Receiver operating characteristic analysis revealed an area under the curve value for IGLR, CAR, CRP, IG, NLR, and ferritin of 0.868, 0.860, 0.834, 0.848, 0.845, 0.841, and 0.827, respectively, which differentiated severe COVID-19 patients from mild and moderate COVID-19 patients.DISCUSSION AND CONCLUSION: The results suggest that the IGLR may be useful to distinguish severe COVID-19 patients at the time of admission. Further exploration is warranted to fully determine the potential value of the IGLR in disease monitoring.</description><subject>Blood tests</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Granulocytes</subject><subject>Intensive care</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Neutrophils</subject><subject>Polymerase chain reaction</subject><issn>2587-2362</issn><issn>2618-642X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNotkM1KAzEcxIMoWGrvHgOet-Y72aPUr0KhHop4K9nsfzVld1OTbKHgwUfwGX0SV_Q0c_jNDAxCl5TMqdBCXPtdV80ZYXROOFXiBE2YoqZQgr2cjl4aXTCu2DmapeQrIsYQZVRM0MdThNq77A-AD7YdAIcG-66zeYiAX6Pthza4YwbswtBnbPsah_wGEfu-ae0vGOIR7220HWSICTch4tonsAlwggNEn48jjBfr5-Xt9-cXLUc6e-hzukBnjW0TzP51ijb3d5vFY7FaPywXN6tiX5pcSAOEV9oqKqCilQStK6WNAecqY52VgmnFmWtKQqQum1ox7UorjYWS65rwKbr6q93H8D5AyttdGGI_Lm45KSUX41WM_wAZBmRI</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Alisik, Murat</creator><creator>Erdogan, Utku Gorkem</creator><creator>Ates, Merve</creator><creator>Mehmet Alp Sert</creator><creator>Ozgur Mehmet Yis</creator><creator>Guler Bugdayci</creator><general>Kare Publishing</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20210101</creationdate><title>Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID‐19 patients</title><author>Alisik, Murat ; Erdogan, Utku Gorkem ; Ates, Merve ; Mehmet Alp Sert ; Ozgur Mehmet Yis ; Guler Bugdayci</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p98t-58e03b7a614eb1b5e77b6788eccb8aca5427632cf900579fd627c9a58ae937d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood tests</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Granulocytes</topic><topic>Intensive care</topic><topic>Leukocytes</topic><topic>Lymphocytes</topic><topic>Neutrophils</topic><topic>Polymerase chain reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alisik, Murat</creatorcontrib><creatorcontrib>Erdogan, Utku Gorkem</creatorcontrib><creatorcontrib>Ates, Merve</creatorcontrib><creatorcontrib>Mehmet Alp Sert</creatorcontrib><creatorcontrib>Ozgur Mehmet Yis</creatorcontrib><creatorcontrib>Guler Bugdayci</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of medical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alisik, Murat</au><au>Erdogan, Utku Gorkem</au><au>Ates, Merve</au><au>Mehmet Alp Sert</au><au>Ozgur Mehmet Yis</au><au>Guler Bugdayci</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID‐19 patients</atitle><jtitle>International journal of medical biochemistry</jtitle><date>2021-01-01</date><risdate>2021</risdate><volume>4</volume><issue>3</issue><spage>143</spage><pages>143-</pages><issn>2587-2362</issn><eissn>2618-642X</eissn><abstract>[LANGUAGE= "English"] INTRODUCTION: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), ferritin level, and CRP-to-albumin ratio (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) and non-COVID-19 patients and to compare these parameters between subgroups according to disease severity. In addition, these parameters were evaluated for predictive value related to the severity of COVID‐19.METHODS: The data of adult patients admitted with a suspected COVID-19 infection confirmed with real-time polymerase chain reaction testing of nasal and pharyngeal swab specimens were included in this retrospective study. Outpatient COVID-19-positive patients were enrolled in the mild group, hospitalized patients were classified in the moderate group, and patients admitted to the intensive care unit were categorized in the severe group.RESULTS: A total of 1213 COVID-19-positive patients and 1034 COVID-19-negative patients were included in the study. The IGLR, NLR, PLR, CRP, CAR, and ferritin levels were significantly higher, and the leukocyte, IG, neutrophil, lymphocyte, monocyte, basophil, and eosinophil levels were significantly lower in the COVID-19-positive group than the COVID-19-negative group (p<0.05 for all). The severe group had higher median IG, IGLR, neutrophil, NLR, PLR levels than the mild, moderate, and COVID-19-negative groups (p<0.05 for all). Receiver operating characteristic analysis revealed an area under the curve value for IGLR, CAR, CRP, IG, NLR, and ferritin of 0.868, 0.860, 0.834, 0.848, 0.845, 0.841, and 0.827, respectively, which differentiated severe COVID-19 patients from mild and moderate COVID-19 patients.DISCUSSION AND CONCLUSION: The results suggest that the IGLR may be useful to distinguish severe COVID-19 patients at the time of admission. Further exploration is warranted to fully determine the potential value of the IGLR in disease monitoring.</abstract><cop>Istanbul</cop><pub>Kare Publishing</pub><doi>10.14744/ijmb.2021.03164</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2587-2362 |
| ispartof | International journal of medical biochemistry, 2021-01, Vol.4 (3), p.143 |
| issn | 2587-2362 2618-642X |
| language | eng |
| recordid | cdi_proquest_journals_3095346182 |
| source | DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | Blood tests Coronaviruses COVID-19 Granulocytes Intensive care Leukocytes Lymphocytes Neutrophils Polymerase chain reaction |
| title | Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID‐19 patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T04%3A55%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predictive%20value%20of%20immature%20granulocyte%20count%20and%20other%20inflammatory%20parameters%20for%20disease%20severity%20in%20COVID%E2%80%9019%20patients&rft.jtitle=International%20journal%20of%20medical%20biochemistry&rft.au=Alisik,%20Murat&rft.date=2021-01-01&rft.volume=4&rft.issue=3&rft.spage=143&rft.pages=143-&rft.issn=2587-2362&rft.eissn=2618-642X&rft_id=info:doi/10.14744/ijmb.2021.03164&rft_dat=%3Cproquest%3E3095346182%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3095346182&rft_id=info:pmid/&rfr_iscdi=true |